IR@PKUHSC  > 北京大学第二临床医学院  > 耳鼻喉科
学科主题临床医学
Regulation of dopamine D2 receptors in the guinea pig cochlea
Wang, Lin1; Li, Jingjing1; Yu, Lisheng1; Li, Xingqi2
关键词Dopamine compound action potential cochlear microphonics distortion product otoacoustic emissions
刊名ACTA OTO-LARYNGOLOGICA
2014-07-01
DOI10.3109/00016489.2014.899712
134期:7页:738-743
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Otorhinolaryngology
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Otorhinolaryngology
关键词[WOS]LATERAL OLIVOCOCHLEAR EFFERENTS ; PHYSIOLOGY ; RELEASE ; NEURONS
英文摘要

Conclusion: Our study demonstrates that the regulation of D2 receptors may be frequency specific. The reduction in cochlear microphonics (CM) and distortion product otoacoustic emission (DPOAE) amplitudes after perfusion with a D2 antagonist suggests that this receptor plays a role in the regulation of cochlear hair cell activation. Objectives: Dopaminergic terminals are subject to negative feedback from dopamine D2 receptors. In the present study we investigated whether the regulation of dopamine D2 receptor is frequency specific and evaluated changes in CM in guinea pig cochlea. Methods: A total of 30 male guinea pigs were randomly assigned to 3 groups and perfused with artificial perilymph (AP), AP containing ethanol (0.1%), or a D2 antagonist (L741626) for 2 h. In each group, compound action potentials (CAPs) evoked by a 1, 2, 4, 8, 16 or 24 kHz tone pip, CM evoked by 4 kHz tone bursts, and DPOAEs were measured before and 2 h after perilymphatic perfusion. Results: Perfusion with the D2 antagonist resulted in increased CAP thresholds compared with the other two groups at high frequencies (4, 8, 16, 24 kHz, p < 0.05); however, no significant increase was observed at low frequencies (1, 2 kHz, p > 0.05). There was a significant reduction in DPOAEs and CM amplitudes after the 2 h perfusion with the D2 antagonist. A CMinput/output (I/O) function curve plotted with the stimulating level as input and the CM relative amplitude as output indicated obvious nonlinearity after the 2 h perfusion in all three groups.

语种英语
所属项目编号81170905
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000337760700012
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66923
Collection北京大学第二临床医学院_耳鼻喉科
作者单位1.Peking Univ, Peoples Hosp, Dept Otolaryngol, Beijing 100044, Peoples R China
2.Chinese Peoples Liberat Army Gen Hosp, Inst Otolaryngol, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Wang, Lin,Li, Jingjing,Yu, Lisheng,et al. Regulation of dopamine D2 receptors in the guinea pig cochlea[J]. ACTA OTO-LARYNGOLOGICA,2014,134(7):738-743.
APA Wang, Lin,Li, Jingjing,Yu, Lisheng,&Li, Xingqi.(2014).Regulation of dopamine D2 receptors in the guinea pig cochlea.ACTA OTO-LARYNGOLOGICA,134(7),738-743.
MLA Wang, Lin,et al."Regulation of dopamine D2 receptors in the guinea pig cochlea".ACTA OTO-LARYNGOLOGICA 134.7(2014):738-743.
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