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IR@PKUHSC  > 北京大学第二临床医学院  > 耳鼻喉科  > 期刊论文
学科主题: 临床医学
题名:
Regulation of dopamine D2 receptors in the guinea pig cochlea
作者: Wang, Lin1; Li, Jingjing1; Yu, Lisheng1; Li, Xingqi2
关键词: Dopamine ; compound action potential ; cochlear microphonics ; distortion product otoacoustic emissions
刊名: ACTA OTO-LARYNGOLOGICA
发表日期: 2014-07-01
DOI: 10.3109/00016489.2014.899712
卷: 134, 期:7, 页:738-743
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Otorhinolaryngology
研究领域[WOS]: Otorhinolaryngology
关键词[WOS]: LATERAL OLIVOCOCHLEAR EFFERENTS ; PHYSIOLOGY ; RELEASE ; NEURONS
英文摘要:

Conclusion: Our study demonstrates that the regulation of D2 receptors may be frequency specific. The reduction in cochlear microphonics (CM) and distortion product otoacoustic emission (DPOAE) amplitudes after perfusion with a D2 antagonist suggests that this receptor plays a role in the regulation of cochlear hair cell activation. Objectives: Dopaminergic terminals are subject to negative feedback from dopamine D2 receptors. In the present study we investigated whether the regulation of dopamine D2 receptor is frequency specific and evaluated changes in CM in guinea pig cochlea. Methods: A total of 30 male guinea pigs were randomly assigned to 3 groups and perfused with artificial perilymph (AP), AP containing ethanol (0.1%), or a D2 antagonist (L741626) for 2 h. In each group, compound action potentials (CAPs) evoked by a 1, 2, 4, 8, 16 or 24 kHz tone pip, CM evoked by 4 kHz tone bursts, and DPOAEs were measured before and 2 h after perilymphatic perfusion. Results: Perfusion with the D2 antagonist resulted in increased CAP thresholds compared with the other two groups at high frequencies (4, 8, 16, 24 kHz, p < 0.05); however, no significant increase was observed at low frequencies (1, 2 kHz, p > 0.05). There was a significant reduction in DPOAEs and CM amplitudes after the 2 h perfusion with the D2 antagonist. A CMinput/output (I/O) function curve plotted with the stimulating level as input and the CM relative amplitude as output indicated obvious nonlinearity after the 2 h perfusion in all three groups.

语种: 英语
所属项目编号: 81170905
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000337760700012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66923
Appears in Collections:北京大学第二临床医学院_耳鼻喉科_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Otolaryngol, Beijing 100044, Peoples R China
2.Chinese Peoples Liberat Army Gen Hosp, Inst Otolaryngol, Beijing, Peoples R China

Recommended Citation:
Wang, Lin,Li, Jingjing,Yu, Lisheng,et al. Regulation of dopamine D2 receptors in the guinea pig cochlea[J]. ACTA OTO-LARYNGOLOGICA,2014,134(7):738-743.
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