IR@PKUHSC  > 北京大学第三临床医学院  > 超声诊断科
学科主题临床医学
Novel ultrasound contrast agent based on microbubbles generated from surfactant mixtures of Span 60 and polyoxyethylene 40 stearate
Xing, Zhanwen1; Ke, Hengte1; Wang, Jinrui2; Zhao, Bo2; Yue, Xiuli1; Dai, Zhifei1; Liu, Jibin3
关键词Microbubbles Monolayer pi-A isotherms Ultrasound contrast agent
刊名ACTA BIOMATERIALIA
2010-09-01
DOI10.1016/j.actbio.2010.03.007
6期:9页:3542-3549
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]Engineering ; Materials Science
关键词[WOS]PARTIAL ESTER EMULSIFIERS ; STABILIZED MICROBUBBLES ; THERAPEUTIC ARTERIOGENESIS ; FILLED MICROBUBBLES ; SORBITAN MONOESTERS ; COATED MICROBUBBLES ; TARGETED DELIVERY ; LANGMUIR TROUGH ; DIETS ; RATS
英文摘要

In this study, novel perfluorocarbon-filled microbubbles as ultrasound contrast agent were fabricated using ultrasonication of a surfactant mixture of sorbitan monostearate (Span 60) and polyoxyethylene 40 stearate (PEG40S) in aqueous media. The microbubbles generated from a 1:9 mixture of PEG40S/Span 60 exhibited an average diameter of 2.08 +/- 1.27 mu m. More than 99% of the microbubbles had a mean particle diameter less than 8 pm, indicating that they were appropriately sized for intravenous administration as ultrasound contrast agent. The stabilization mechanism of the microbubbles was investigated by the Langmuir-Blodgett technique including the measurements of surface pressure-area (pi-A) isotherms and compression-decompression cycles with a two-dimensional monolayer of Span 60 and PEG40S. The dependence on molar fraction of PEG4OS in pi-A isotherms of mixed monolayers provided a strong evidence of interactions between the two microbubble-forming materials. It is suggested that the monolayer shell imparts good stability to the microbubbles by three means: (1) a low surface tension monolayer hinders dissolution through the reduction of surface tension, which introduces a mechanical surface pressure that counters the Laplace pressure; (2) the presence of a monolayer shell imparts a significant barrier to gas escaping from the core into the aqueous medium; and (3) encapsulation elasticity stabilizes microbubbles against diffusion-driven dissolution and explains the long shelf-life of microbubble contrast agent. The preliminary in vivo ultrasound imaging study showed that such stabilized microbubbles demonstrated excellent enhancement under grey-scale pulse inversion harmonic imaging and power Doppler imaging. (C) 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000281318400020
引用统计
被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66925
专题北京大学第三临床医学院_超声诊断科
作者单位1.Harbin Inst Technol, Sch Sci, State Key Lab Urban Water Resources & Environm, Nanobiotechnol Div,BioX Ctr, Harbin 150080, Peoples R China
2.Peking Univ, Hosp 3, Dept Ultrasonog, Beijing 100083, Peoples R China
3.Thomas Jefferson Univ, Ultrasound Res & Educ Inst, Philadelphia, PA 19107 USA
推荐引用方式
GB/T 7714
Xing, Zhanwen,Ke, Hengte,Wang, Jinrui,et al. Novel ultrasound contrast agent based on microbubbles generated from surfactant mixtures of Span 60 and polyoxyethylene 40 stearate[J]. ACTA BIOMATERIALIA,2010,6(9):3542-3549.
APA Xing, Zhanwen.,Ke, Hengte.,Wang, Jinrui.,Zhao, Bo.,Yue, Xiuli.,...&Liu, Jibin.(2010).Novel ultrasound contrast agent based on microbubbles generated from surfactant mixtures of Span 60 and polyoxyethylene 40 stearate.ACTA BIOMATERIALIA,6(9),3542-3549.
MLA Xing, Zhanwen,et al."Novel ultrasound contrast agent based on microbubbles generated from surfactant mixtures of Span 60 and polyoxyethylene 40 stearate".ACTA BIOMATERIALIA 6.9(2010):3542-3549.
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