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IR@PKUHSC  > 北京大学第三临床医学院  > 超声诊断科  > 期刊论文
学科主题: 临床医学
题名:
Novel ultrasound contrast agent based on microbubbles generated from surfactant mixtures of Span 60 and polyoxyethylene 40 stearate
作者: Xing, Zhanwen1; Ke, Hengte1; Wang, Jinrui2; Zhao, Bo2; Yue, Xiuli1; Dai, Zhifei1; Liu, Jibin3
关键词: Microbubbles ; Monolayer ; pi-A isotherms ; Ultrasound contrast agent
刊名: ACTA BIOMATERIALIA
发表日期: 2010-09-01
DOI: 10.1016/j.actbio.2010.03.007
卷: 6, 期:9, 页:3542-3549
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]: Engineering ; Materials Science
关键词[WOS]: PARTIAL ESTER EMULSIFIERS ; STABILIZED MICROBUBBLES ; THERAPEUTIC ARTERIOGENESIS ; FILLED MICROBUBBLES ; SORBITAN MONOESTERS ; COATED MICROBUBBLES ; TARGETED DELIVERY ; LANGMUIR TROUGH ; DIETS ; RATS
英文摘要:

In this study, novel perfluorocarbon-filled microbubbles as ultrasound contrast agent were fabricated using ultrasonication of a surfactant mixture of sorbitan monostearate (Span 60) and polyoxyethylene 40 stearate (PEG40S) in aqueous media. The microbubbles generated from a 1:9 mixture of PEG40S/Span 60 exhibited an average diameter of 2.08 +/- 1.27 mu m. More than 99% of the microbubbles had a mean particle diameter less than 8 pm, indicating that they were appropriately sized for intravenous administration as ultrasound contrast agent. The stabilization mechanism of the microbubbles was investigated by the Langmuir-Blodgett technique including the measurements of surface pressure-area (pi-A) isotherms and compression-decompression cycles with a two-dimensional monolayer of Span 60 and PEG40S. The dependence on molar fraction of PEG4OS in pi-A isotherms of mixed monolayers provided a strong evidence of interactions between the two microbubble-forming materials. It is suggested that the monolayer shell imparts good stability to the microbubbles by three means: (1) a low surface tension monolayer hinders dissolution through the reduction of surface tension, which introduces a mechanical surface pressure that counters the Laplace pressure; (2) the presence of a monolayer shell imparts a significant barrier to gas escaping from the core into the aqueous medium; and (3) encapsulation elasticity stabilizes microbubbles against diffusion-driven dissolution and explains the long shelf-life of microbubble contrast agent. The preliminary in vivo ultrasound imaging study showed that such stabilized microbubbles demonstrated excellent enhancement under grey-scale pulse inversion harmonic imaging and power Doppler imaging. (C) 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: NSFC-30970829 ; NSFC-30672001 ; 2007AA03Z316 ; 707021 ; HIT-2008QN06
项目资助者: National Natural Science Foundation of China ; National High Technology Research and Development Program of China ; Ministry of Education of China ; State Key Laboratory of Urban Water Resource and Environment
WOS记录号: WOS:000281318400020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66925
Appears in Collections:北京大学第三临床医学院_超声诊断科_期刊论文

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作者单位: 1.Harbin Inst Technol, Sch Sci, State Key Lab Urban Water Resources & Environm, Nanobiotechnol Div,BioX Ctr, Harbin 150080, Peoples R China
2.Peking Univ, Hosp 3, Dept Ultrasonog, Beijing 100083, Peoples R China
3.Thomas Jefferson Univ, Ultrasound Res & Educ Inst, Philadelphia, PA 19107 USA

Recommended Citation:
Xing, Zhanwen,Ke, Hengte,Wang, Jinrui,et al. Novel ultrasound contrast agent based on microbubbles generated from surfactant mixtures of Span 60 and polyoxyethylene 40 stearate[J]. ACTA BIOMATERIALIA,2010,6(9):3542-3549.
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