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学科主题: 临床医学
题名:
Pemetrexed is Mildly Active with Good Tolerability for Treatment of Patients with Colorectal Cancer
作者: Zhang, Hui-Qing1; Lian, Chang-Hong1; Ping, Yao-Dong3; Song, Wen-Bin1; Lu, Qing-Pu; Xie, Shu-Zhe; Lin, Tao; Cheng, Lin-Zhong2
关键词: Metastatic colorectal cancer ; pemetrexed chemotherapy ; response rate
刊名: ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
发表日期: 2014
DOI: 10.7314/APJCP.2014.15.19.8391
卷: 15, 期:19, 页:8391-8394
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: PLUS IRINOTECAN ; PHASE-II ; MULTITARGETED ANTIFOLATE ; LY231514 ; CHEMOTHERAPY ; CARCINOMA ; DISODIUM ; ENZYMES
英文摘要:

Purpose: This systematic analysis was conducted to evaluate the efficacy and safety of pemetrexed based salvage chemotherapy for treatment of patients with metastatic colorectal cancer. Methods: Clinical studies evaluating the efficacy and safety of pemetrexed based regimens on response and safety for patients with colorectal cancer were identified using a predefined search strategy. Pooled response rates (RRs) were calculated. Results: For pemetrexed based regimens, 4 clinical studies including 201 patients with advanced colorectal cancer were considered eligible for inclusion. The analysis suggested that, in all patients, pooled RR was 20.4% (41/201). Major adverse effects were neutropenia, anorexia, fatigue, and anemia. No treatment related death occurred with pemetrexed based treatment. Conclusion: This systematic analysis suggests that pemetrexed based regimens are associated with mild activity with good tolerability in treating patients with metastatic colorectal cancer.

语种: 英语
WOS记录号: WOS:000343833800058
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66928
Appears in Collections:北京大学临床肿瘤学院_药剂科_期刊论文

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作者单位: 1.Heping Hosp, Changzhi Med Coll, Dept Gen Surg, Changzhi, Shanxi, Peoples R China
2.Heping Hosp, Changzhi Med Coll, Dept Pharm, Changzhi, Shanxi, Peoples R China
3.Peking Univ, Dept Pharm, Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100871, Peoples R China

Recommended Citation:
Zhang, Hui-Qing,Lian, Chang-Hong,Ping, Yao-Dong,et al. Pemetrexed is Mildly Active with Good Tolerability for Treatment of Patients with Colorectal Cancer[J]. ASIAN PACIFIC JOURNAL OF CANCER PREVENTION,2014,15(19):8391-8394.
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