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学科主题: 基础医学
题名:
P2X7 Mediates ATP-Driven Invasiveness in Prostate Cancer Cells
作者: Qiu, Ying1,2; Li, Wei-hua1,2; Zhang, Hong-quan1,3; Liu, Yan1,2; Tian, Xin-Xia1,2; Fang, Wei-Gang1,2
刊名: PLOS ONE
发表日期: 2014-12-08
DOI: 10.1371/journal.pone.0114371
卷: 9, 期:12
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: P2X(7) RECEPTOR EXPRESSION ; EXTRACELLULAR ATP ; IN-VIVO ; PURINERGIC RECEPTORS ; TUMOR PROGRESSION ; CARCINOMA-CELLS ; METASTASIS ; GROWTH ; PROLIFERATION ; INTERLEUKIN-8
英文摘要:

The ATP-gated P2X7 has been shown to play an important role in invasiveness and metastasis of some tumors. However, the possible links and underlying mechanisms between P2X7 and prostate cancer have not been elucidated. Here, we demonstrated that P2X7 was highly expressed in some prostate cancer cells. Down-regulation of P2X7 by siRNA significantly attenuated ATP- or BzATP-driven migration and invasion of prostate cancer cells in vitro, and inhibited tumor invasiveness and metastases in nude mice. In addition, silencing of P2X7 remarkably attenuated ATP- or BzATP-driven expression changes of EMT/invasion-related genes Snail, E-cadherin, Claudin-1, IL-8 and MMP-3, and weakened the phosphorylation of PI3K/AKT and ERK1/2 in vitro. Similar effects were observed in nude mice. These data indicate that P2X7 stimulates cell invasion and metastasis in prostate cancer cells via some EMT/invasion-related genes, as well as PI3K/AKT and ERK1/2 signaling pathways. P2X7 could be a promising therapeutic target for prostate cancer.

语种: 英语
所属项目编号: 81321003 ; 30971152 ; 2010CB529402
项目资助者: National Natural Science Foundation of China ; Ministry of Science and Technology of China
WOS记录号: WOS:000346907600048
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66933
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Minist Educ, Key Lab Carcinogenesis & Translat Res, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Pathol, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Anat Histol & Embryol, Beijing 100191, Peoples R China

Recommended Citation:
Qiu, Ying,Li, Wei-hua,Zhang, Hong-quan,et al. P2X7 Mediates ATP-Driven Invasiveness in Prostate Cancer Cells[J]. PLOS ONE,2014,9(12).
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