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学科主题基础医学
P2X7 Mediates ATP-Driven Invasiveness in Prostate Cancer Cells
Qiu, Ying1,2; Li, Wei-hua1,2; Zhang, Hong-quan1,3; Liu, Yan1,2; Tian, Xin-Xia1,2; Fang, Wei-Gang1,2
刊名PLOS ONE
2014-12-08
DOI10.1371/journal.pone.0114371
9期:12
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]P2X(7) RECEPTOR EXPRESSION ; EXTRACELLULAR ATP ; IN-VIVO ; PURINERGIC RECEPTORS ; TUMOR PROGRESSION ; CARCINOMA-CELLS ; METASTASIS ; GROWTH ; PROLIFERATION ; INTERLEUKIN-8
英文摘要

The ATP-gated P2X7 has been shown to play an important role in invasiveness and metastasis of some tumors. However, the possible links and underlying mechanisms between P2X7 and prostate cancer have not been elucidated. Here, we demonstrated that P2X7 was highly expressed in some prostate cancer cells. Down-regulation of P2X7 by siRNA significantly attenuated ATP- or BzATP-driven migration and invasion of prostate cancer cells in vitro, and inhibited tumor invasiveness and metastases in nude mice. In addition, silencing of P2X7 remarkably attenuated ATP- or BzATP-driven expression changes of EMT/invasion-related genes Snail, E-cadherin, Claudin-1, IL-8 and MMP-3, and weakened the phosphorylation of PI3K/AKT and ERK1/2 in vitro. Similar effects were observed in nude mice. These data indicate that P2X7 stimulates cell invasion and metastasis in prostate cancer cells via some EMT/invasion-related genes, as well as PI3K/AKT and ERK1/2 signaling pathways. P2X7 could be a promising therapeutic target for prostate cancer.

语种英语
WOS记录号WOS:000346907600048
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被引频次:34[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66933
专题北京大学基础医学院_病理学系
北京大学医学部管理机构_主任办公室党委办公室
北京大学基础医学院
作者单位1.Peking Univ, Hlth Sci Ctr, Minist Educ, Key Lab Carcinogenesis & Translat Res, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Pathol, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Anat Histol & Embryol, Beijing 100191, Peoples R China
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GB/T 7714
Qiu, Ying,Li, Wei-hua,Zhang, Hong-quan,et al. P2X7 Mediates ATP-Driven Invasiveness in Prostate Cancer Cells[J]. PLOS ONE,2014,9(12).
APA Qiu, Ying,Li, Wei-hua,Zhang, Hong-quan,Liu, Yan,Tian, Xin-Xia,&Fang, Wei-Gang.(2014).P2X7 Mediates ATP-Driven Invasiveness in Prostate Cancer Cells.PLOS ONE,9(12).
MLA Qiu, Ying,et al."P2X7 Mediates ATP-Driven Invasiveness in Prostate Cancer Cells".PLOS ONE 9.12(2014).
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