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学科主题医学信息学
A Network of Cancer Genes with Co-Occurring and Anti-Co-Occurring Mutations
Cui, Qinghua
刊名PLOS ONE
2010-10-04
DOI10.1371/journal.pone.0013180
5期:10
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]COLORECTAL CANCERS ; HUMAN BREAST ; SIMILARITY ; PATTERNS
英文摘要

Certain cancer genes contribute to tumorigenesis in a manner of either co-occurring or mutually exclusive (anti-co-occurring) mutations; however, the global picture of when, where and how these functional interactions occur remains unclear. This study presents a systems biology approach for this purpose. After applying this method to cancer gene mutation data generated from large-scale and whole genome sequencing of cancer samples, a network of cancer genes with co-occurring and anti-co-occurring mutations was constructed. Analysis of this network revealed that genes with co-occurring mutations prefer direct signaling transductions and that the interaction relations among cancer genes in the network are related with their functional similarity. It was also revealed that genes with co-occurring mutations tend to have similar mutation frequencies, whereas genes with anti-co-occurring mutations tend to have different mutation frequencies. Moreover, genes with more exons tend to have more co-occurring mutations with other genes, and genes having lower local coherent network structures tend to have higher mutation frequency. The network showed two complementary modules that have distinct functions and have different roles in tumorigenesis. This study presented a framework for the analysis of cancer genome sequencing outputs. The presented data and uncovered patterns are helpful for understanding the contribution of gene mutations to tumorigenesis and valuable in the identification of key biomarkers and drug targets for cancer.

语种英语
WOS记录号WOS:000282423300016
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66939
专题北京大学基础医学院_医学信息学系
作者单位Peking Univ, Hlth Sci Ctr, Dept Biomed Informat, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Cui, Qinghua. A Network of Cancer Genes with Co-Occurring and Anti-Co-Occurring Mutations[J]. PLOS ONE,2010,5(10).
APA Cui, Qinghua.(2010).A Network of Cancer Genes with Co-Occurring and Anti-Co-Occurring Mutations.PLOS ONE,5(10).
MLA Cui, Qinghua."A Network of Cancer Genes with Co-Occurring and Anti-Co-Occurring Mutations".PLOS ONE 5.10(2010).
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