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学科主题: 临床医学
题名:
Anti-endothelial cell antibodies in antineutrophil cytoplasmic antibodies negative pauci-immune crescentic glomerulonephritis
作者: Cong, Min2; Chen, Min2; Zhang, Jun-Jun2; Hu, Zhao1; Zhao, Ming-Hui2
关键词: antiendothelial cell antibodies ; antineutrophil cytoplasmic antibodies ; crescentic glomerulonephritis ; pauci-immune ; vasculitis
刊名: NEPHROLOGY
发表日期: 2008-04-01
DOI: 10.1111/j.1440-1797.2007.00894.x
卷: 13, 期:3, 页:228-234
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: SMALL-VESSEL VASCULITIS ; SYSTEMIC VASCULITIS ; ENDOTHELIAL-CELLS ; IN-VITRO ; DISEASE ; MYELOPEROXIDASE ; BINDING
英文摘要:

Aim: Pauci-immune crescentic glomerulonephritis (CrGN) is frequently associated with circulating anti-neutrophil cytoplasmic antibodies (ANCA). However, in patients with ANCA-negative pauci-immune CrGN, the pathogenesis is not clear. Anti-endothelial cell antibodies (AECA) have been implicated in the pathogenesis of vasculitis. The purpose of this study is to investigate the prevalence of AECA and their possible clinical significance in ANCA-negative pauci-immune CrGN.

Methods: Sera from 19 patients with ANCA-negative pauci-immune CrGN, 26 patients with ANCA-positive pauci-immune CrGN and 10 healthy blood donors were collected. Soluble proteins extracted from cultured human umbilical vein endothelial cells were used as antigens and western blot analysis was carried out to detect AECA.

Results: In ANCA-negative pauci-immune CrGN, 10 of 19 patients were serum IgG-AECA positive and seven bands reactive with endothelial antigens could be blotted. The prevalence of skin rash and thrombocytosis was significantly higher in patients with anti-76 kDa and anti-123 kDa autoantibodies than in patients without, respectively. Birmingham Vasculitis Activity Scores of patients with anti-200 kDa AECA were significantly higher than in patients without. In the sera of 26 ANCA-positive cases, 23 were AECA positive and 11 bands could be recognized. The prevalence of total AECA and anti-90 kDa AECA was significantly lower in patients with ANCA-negative pauci-immune CrGN than in patients with ANCA-positive pauci-immune CrGN.

Conclusion: Anti-endothelial cell antibodies could be found in sera of patients with ANCA-negative pauci-immune CrGN; some AECA might have some clinical significance. The discrepancies of AECA might be a possible contributor to the differences between ANCA-negative and ANCA-positive pauci-immune CrGN.

语种: 英语
WOS记录号: WOS:000254578500008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66948
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Shandong Univ, Qilu Hosp, Div Renal, Jinan 250100, Shandong, Peoples R China
2.Peking Univ, Inst Nephrol, Peking Univ Hosp 1, Dept Med,Renal Div,Key Lab Renal Dis,Minist Hlth, Beijing 100034, Peoples R China

Recommended Citation:
Cong, Min,Chen, Min,Zhang, Jun-Jun,et al. Anti-endothelial cell antibodies in antineutrophil cytoplasmic antibodies negative pauci-immune crescentic glomerulonephritis[J]. NEPHROLOGY,2008,13(3):228-234.
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