|The effect of tension on esophagogastric anastomotic wound healing in rats|
|Cui, Y; Chen, H|
|关键词||esophagectomy gastrectomy anastomosis, surgical wound healing postoperative complications|
|刊名||JOURNAL OF CARDIOVASCULAR SURGERY|
|WOS标题词||Science & Technology|
|类目[WOS]||Cardiac & Cardiovascular Systems ; Surgery ; Peripheral Vascular Disease|
|研究领域[WOS]||Cardiovascular System & Cardiology ; Surgery|
|关键词[WOS]||PREDISPOSING FACTORS ; ESOPHAGEAL ; CARCINOMA ; CANCER ; LEAK|
Aim. The effect of tension on the occurrence of esophagogastric anastomotic leaks has been controversial for a long time. We used a rat model and investigated the effect of tension on the esophagogastric anastomotic wound healing.
Methods. Eighty Sprague-Dawley rats were divided into 8 groups and each group has 10 rats. A side-to-side single layer esophagogastric anastomosis was constructed using interrupted sutures through laparotomy. Anastomoses ware excised on day 0, 3, 5, 7, 14, mounted in an Instron mini-44 Tensionmeter and distracted at 10 mm/min to measure breaking strength. On the other hand, the increased anastomotic tensions were obtained by increasing the distance between esophageal incision and gastrotomy, and anastomotic leak rates in different anastomotic tension groups were investigated.
Results. A total of 11 rats were excluded from the studies because of pulmonary complication. Breaking strength on day 0, 3, 5, 7, 14 were 3.35 +/- 0.89, 1.18 +/- 0.31, 1.92 +/- 0.46, 3.47 +/- 0.83, 5.06 +/- 1.22 (Newton), respectively. The breaking strength is significantly different between day 0 and day 3, day 5 and day 7, day 7 and day 14 (p<0.05). There is no difference between day 3 and day 5, day 0 and day 7 (p>0.05). Breaking strength is lowest on day 3 and close to culmination on day 14. Esophagogastric anastomotic leaks increased along with anastomotic tension increasing.
Conclusion Anastomotic tension could be a key factor resulting in esophagogastric anastomotic leaks.
|作者单位||1.Beijing Univ, Hosp 1, Dept Thorac Surg, Beijing 100034, Peoples R China|
2.Roswell Pk Canc Inst, Dept Thorac Surg, Buffalo, NY 14263 USA
|Cui, Y,Chen, H. The effect of tension on esophagogastric anastomotic wound healing in rats[J]. JOURNAL OF CARDIOVASCULAR SURGERY,2003,44(6):775-778.|
|APA||Cui, Y,&Chen, H.(2003).The effect of tension on esophagogastric anastomotic wound healing in rats.JOURNAL OF CARDIOVASCULAR SURGERY,44(6),775-778.|
|MLA||Cui, Y,et al."The effect of tension on esophagogastric anastomotic wound healing in rats".JOURNAL OF CARDIOVASCULAR SURGERY 44.6(2003):775-778.|