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学科主题: 临床医学
题名:
The effect of tension on esophagogastric anastomotic wound healing in rats
作者: Cui, Y; Chen, H
关键词: esophagectomy ; gastrectomy ; anastomosis, surgical ; wound healing ; postoperative complications
刊名: JOURNAL OF CARDIOVASCULAR SURGERY
发表日期: 2003-12-01
卷: 44, 期:6, 页:775-778
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems ; Surgery ; Peripheral Vascular Disease
研究领域[WOS]: Cardiovascular System & Cardiology ; Surgery
关键词[WOS]: PREDISPOSING FACTORS ; ESOPHAGEAL ; CARCINOMA ; CANCER ; LEAK
英文摘要:

Aim. The effect of tension on the occurrence of esophagogastric anastomotic leaks has been controversial for a long time. We used a rat model and investigated the effect of tension on the esophagogastric anastomotic wound healing.

Methods. Eighty Sprague-Dawley rats were divided into 8 groups and each group has 10 rats. A side-to-side single layer esophagogastric anastomosis was constructed using interrupted sutures through laparotomy. Anastomoses ware excised on day 0, 3, 5, 7, 14, mounted in an Instron mini-44 Tensionmeter and distracted at 10 mm/min to measure breaking strength. On the other hand, the increased anastomotic tensions were obtained by increasing the distance between esophageal incision and gastrotomy, and anastomotic leak rates in different anastomotic tension groups were investigated.

Results. A total of 11 rats were excluded from the studies because of pulmonary complication. Breaking strength on day 0, 3, 5, 7, 14 were 3.35 +/- 0.89, 1.18 +/- 0.31, 1.92 +/- 0.46, 3.47 +/- 0.83, 5.06 +/- 1.22 (Newton), respectively. The breaking strength is significantly different between day 0 and day 3, day 5 and day 7, day 7 and day 14 (p<0.05). There is no difference between day 3 and day 5, day 0 and day 7 (p>0.05). Breaking strength is lowest on day 3 and close to culmination on day 14. Esophagogastric anastomotic leaks increased along with anastomotic tension increasing.

Conclusion Anastomotic tension could be a key factor resulting in esophagogastric anastomotic leaks.

语种: 英语
WOS记录号: WOS:000188941600019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66949
Appears in Collections:北京大学第一临床医学院_胸外科_期刊论文

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作者单位: 1.Beijing Univ, Hosp 1, Dept Thorac Surg, Beijing 100034, Peoples R China
2.Roswell Pk Canc Inst, Dept Thorac Surg, Buffalo, NY 14263 USA

Recommended Citation:
Cui, Y,Chen, H. The effect of tension on esophagogastric anastomotic wound healing in rats[J]. JOURNAL OF CARDIOVASCULAR SURGERY,2003,44(6):775-778.
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