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The effect of tension on esophagogastric anastomotic wound healing in rats
Cui, Y; Chen, H
关键词esophagectomy gastrectomy anastomosis, surgical wound healing postoperative complications
刊名JOURNAL OF CARDIOVASCULAR SURGERY
2003-12-01
44期:6页:775-778
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems ; Surgery ; Peripheral Vascular Disease
研究领域[WOS]Cardiovascular System & Cardiology ; Surgery
关键词[WOS]PREDISPOSING FACTORS ; ESOPHAGEAL ; CARCINOMA ; CANCER ; LEAK
英文摘要

Aim. The effect of tension on the occurrence of esophagogastric anastomotic leaks has been controversial for a long time. We used a rat model and investigated the effect of tension on the esophagogastric anastomotic wound healing.

Methods. Eighty Sprague-Dawley rats were divided into 8 groups and each group has 10 rats. A side-to-side single layer esophagogastric anastomosis was constructed using interrupted sutures through laparotomy. Anastomoses ware excised on day 0, 3, 5, 7, 14, mounted in an Instron mini-44 Tensionmeter and distracted at 10 mm/min to measure breaking strength. On the other hand, the increased anastomotic tensions were obtained by increasing the distance between esophageal incision and gastrotomy, and anastomotic leak rates in different anastomotic tension groups were investigated.

Results. A total of 11 rats were excluded from the studies because of pulmonary complication. Breaking strength on day 0, 3, 5, 7, 14 were 3.35 +/- 0.89, 1.18 +/- 0.31, 1.92 +/- 0.46, 3.47 +/- 0.83, 5.06 +/- 1.22 (Newton), respectively. The breaking strength is significantly different between day 0 and day 3, day 5 and day 7, day 7 and day 14 (p<0.05). There is no difference between day 3 and day 5, day 0 and day 7 (p>0.05). Breaking strength is lowest on day 3 and close to culmination on day 14. Esophagogastric anastomotic leaks increased along with anastomotic tension increasing.

Conclusion Anastomotic tension could be a key factor resulting in esophagogastric anastomotic leaks.

语种英语
WOS记录号WOS:000188941600019
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66949
专题北京大学第一临床医学院_胸外科
作者单位1.Beijing Univ, Hosp 1, Dept Thorac Surg, Beijing 100034, Peoples R China
2.Roswell Pk Canc Inst, Dept Thorac Surg, Buffalo, NY 14263 USA
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GB/T 7714
Cui, Y,Chen, H. The effect of tension on esophagogastric anastomotic wound healing in rats[J]. JOURNAL OF CARDIOVASCULAR SURGERY,2003,44(6):775-778.
APA Cui, Y,&Chen, H.(2003).The effect of tension on esophagogastric anastomotic wound healing in rats.JOURNAL OF CARDIOVASCULAR SURGERY,44(6),775-778.
MLA Cui, Y,et al."The effect of tension on esophagogastric anastomotic wound healing in rats".JOURNAL OF CARDIOVASCULAR SURGERY 44.6(2003):775-778.
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