IR@PKUHSC  > 北京大学第二临床医学院  > 胃肠外科
学科主题临床医学
An anatomical, histopathological, and molecular biological function study of the fascias posterior to the interperitoneal colon and its associated mesocolon: their relevance to colonic surgery
Gao, Zhidong1,2; Ye, Yingjiang1,2; Zhang, Weiguang3; Shen, Danhua4; Zhong, Yanfeng5; Jiang, Kewei1,2; Yang, Xiaodong1; Yin, Mujun1; Liang, Bin1; Tian, Long3; Wang, Shan1,2
关键词anatomy complete mesocolic excision histopathology interperitoneal colon parietal fascia visceral fascia
刊名JOURNAL OF ANATOMY
2013-08-01
DOI10.1111/joa.12066
223期:2页:123-132
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Anatomy & Morphology
资助者Committee of the Beijing Municipal Science and Technology Commission ; Capital Health Research and Development of Special ; Clinical Application and Development of Capital Characteristic ; Peking University People&prime ; s Hospital Research and Development Funds of China ; Committee of the Beijing Municipal Science and Technology Commission ; Capital Health Research and Development of Special ; Clinical Application and Development of Capital Characteristic ; Peking University People&prime ; s Hospital Research and Development Funds of China
研究领域[WOS]Anatomy & Morphology
关键词[WOS]RECTAL-CANCER SURGERY ; COMPUTED-TOMOGRAPHY ; PERIRENAL SPACE ; COMMUNICATION ; MESORECTUM ; SURVIVAL ; LIGATION ; EXCISION ; ADULT ; CT
英文摘要

The study aim was to explore the anatomy, histopathology, and molecular biological function of the fascias posterior to the interperitoneal colon and its mesocolon to provide information for improving complete mesocolic excision. To accomplish this aim, we performed intraoperative observations in 60 interperitoneal colon-cancer patients accepted for complete mesocolic excision and conducted local anatomy observations for five embalmed cadavers. An additional two embalmed child cadaver specimens were studied with large slices and paraffin sections. Ten of the 60 patients were examined with a lymph node tracer technique in vivo, while fresh specimens from these patients were assessed by histopathological examination and transwell cell migration assays in vitro. The anatomical and histopathological findings showed that the fascias posterior to the interperitoneal colon and its associated mesocolon were composed of two independent layers: the visceral and parietal fascias. These two fascias were primarily composed of collagen fibers, with the parietal fascia containing a small amount of muscle fiber. The in vivo test showed that the visceral fascia surrounded the colon and its associated mesocolon, including vessels and lymphatics, and that it had no lymphatic flow through it into the rear tissues. Moreover, the in vitro assays showed the visceral fascia was able to block tumor cell migration. Although many surgical scholars have known of the existence of fascia tissue posterior to the intraperitoneal colon, the detailed structure has been ignored and been unclear. As shown by our findings, the visceral and parietal fascias are truly formed structures that have not been previously reported. A thorough understanding of fascial structures and the function of the visceral fascia barrier in blocking tumor cells will facilitate surgeons when performing high-quality complete mesocolic excision procedures.

语种英语
所属项目编号2011-4022-05 ; Z111107058811046 ; RDB2012-19
资助者Committee of the Beijing Municipal Science and Technology Commission ; Capital Health Research and Development of Special ; Clinical Application and Development of Capital Characteristic ; Peking University People&prime ; s Hospital Research and Development Funds of China ; Committee of the Beijing Municipal Science and Technology Commission ; Capital Health Research and Development of Special ; Clinical Application and Development of Capital Characteristic ; Peking University People&prime ; s Hospital Research and Development Funds of China
WOS记录号WOS:000321447100003
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66950
专题北京大学第二临床医学院_胃肠外科
作者单位1.Peking Univ, Peoples Hosp, Dept Gastrointestinal Surg, Beijing 100044, Peoples R China
2.Peking Univ, Peoples Hosp, Lab Surg Oncol, Beijing 100044, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Human Anat Histol & Embryol, Beijing 100044, Peoples R China
4.Peking Univ, Peoples Hosp, Dept Pathol, Beijing 100044, Peoples R China
5.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Gao, Zhidong,Ye, Yingjiang,Zhang, Weiguang,et al. An anatomical, histopathological, and molecular biological function study of the fascias posterior to the interperitoneal colon and its associated mesocolon: their relevance to colonic surgery[J]. JOURNAL OF ANATOMY,2013,223(2):123-132.
APA Gao, Zhidong.,Ye, Yingjiang.,Zhang, Weiguang.,Shen, Danhua.,Zhong, Yanfeng.,...&Wang, Shan.(2013).An anatomical, histopathological, and molecular biological function study of the fascias posterior to the interperitoneal colon and its associated mesocolon: their relevance to colonic surgery.JOURNAL OF ANATOMY,223(2),123-132.
MLA Gao, Zhidong,et al."An anatomical, histopathological, and molecular biological function study of the fascias posterior to the interperitoneal colon and its associated mesocolon: their relevance to colonic surgery".JOURNAL OF ANATOMY 223.2(2013):123-132.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Gao, Zhidong]的文章
[Ye, Yingjiang]的文章
[Zhang, Weiguang]的文章
百度学术
百度学术中相似的文章
[Gao, Zhidong]的文章
[Ye, Yingjiang]的文章
[Zhang, Weiguang]的文章
必应学术
必应学术中相似的文章
[Gao, Zhidong]的文章
[Ye, Yingjiang]的文章
[Zhang, Weiguang]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。