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学科主题: 临床医学
题名:
Research on Application of Fourier Transform Infrared Spectrometry in the Diagnosis of Lymph Node Metastasis in Gastric Cancer
作者: Bai Yue-kui1; Yu Li-wei1; Zhang Le1; Fu Jing2; Leng Hui2; Yang Xiao-jun3; Ma Jun-qiang3; Li Xiao-juan3; Li Xiu-juan3; Zhu Qing4; Zhang Yuan-fu4; Ling Xiao-feng5; Cao Wen-Lan6
关键词: Fourier transform infrared spectrometry ; Gastric cancer ; Lymph node ; Diagnosis
刊名: SPECTROSCOPY AND SPECTRAL ANALYSIS
发表日期: 2015-03-01
DOI: 10.3964/j.issn.1000-0593(2015)03-0599-04
卷: 35, 期:3, 页:599-602
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Spectroscopy
研究领域[WOS]: Spectroscopy
关键词[WOS]: SPECTROSCOPY ; MICROSPECTROSCOPY
英文摘要:

To explore the feasibility of quick intraoperative in situ and noninvasive diagnosis of lymph node metastasis in gastric cancer by Fourier transform infrared (FTIR) spectrometry. FTIR spectra of surgically removed fresh lymph nodes were measured by FTIR via probe of attenuated total reflection (ATR). For each spectrum, 13 bands were indentified and assigned between 3 000 and 1 000 cm(-1). Peaks in the spectra were measured and relative intensity ratios were calculated and compared between the spectra of Metastatic lymph nodes (MLN) and Non-metastatic lymph nodes(NMLN). Standard statistic analysis was performed. 720 lymph nodes were measured in 38 gastric cancer patients. Results show that there were significant differences between the FTIR of 540 MLN and 180 NMLN. (1) For the band related to nucleic acid: The ratios of I-1240/I-1460 (p=0. 015) and I-1080//I-1460 (p=0. 034) increased in MLN, which shows that the relative quantity of nucleic acid was more in MLN than that in NMLN. (2) For the bands related to protein: The ratios of I-1640/I-1460 (p=0. 001) and I-1546/I-1460 (p=0. 027) increased in MLN, which shows that the relative quantity of protein was more in MLN. (3) For the bands related to lipid: The ratio of I-2855/I-1460 and I-1740/I-1460 decreased in MLN FTIR spectrum, indicating the lower relative quantity of lipid in MLN. (4) For the bands related to carbohydrate: The ratio of I-1160/I-1460 (p=0. 023) decreased in MLN FTIR spectrum, indicating the lower relative quantity of carbohydrate in MLN. The results demonstrate that the FTIR spectroscopy technique maybe develop into a promising method for in situ and quick intraoperative differential diagnosis of lymph node metastasis in gastric cancer.

语种: 中文
WOS记录号: WOS:000351025600006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66954
Appears in Collections:北京大学第三临床医学院_普通外科_期刊论文

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作者单位: 1.Beijing Haidian Hosp, Dept Gen Surg, Beijing 100080, Peoples R China
2.Beijing Haidian Hosp, Dept Pathol, Beijing 100080, Peoples R China
3.Yuncheng Cent Hosp Shanxi Prov, Yuncheng 044000, Peoples R China
4.Peking Univ, Coll Chem & Mol Engn, Beijing 100871, Peoples R China
5.Peking Univ, Hosp 3, Dept Gen Surg, Beijing 100191, Peoples R China
6.China Acad Chinese Med Sci, Xiyuan Hosp, Dept Oncol, Beijing 100091, Peoples R China

Recommended Citation:
Bai Yue-kui,Yu Li-wei,Zhang Le,et al. Research on Application of Fourier Transform Infrared Spectrometry in the Diagnosis of Lymph Node Metastasis in Gastric Cancer[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS,2015,35(3):599-602.
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