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Effects of Formaldehyde on Lymphocyte Subsets and Cytokines in the Peripheral Blood of Exposed Workers
Jia, Xiaowei1; Jia, Qiang2; Zhang, Zhihu2; Gao, Weimin3; Zhang, Xianan1; Niu, Yong1; Meng, Tao1; Feng, Bin2; Duan, Huawei1; Ye, Meng1; Dai, Yufei1; Jia, Zhongwei4; Zheng, Yuxin1
刊名PLOS ONE
2014-08-26
DOI10.1371/journal.pone.0104069
9期:8
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]CONTACT-DERMATITIS GROUP ; T-CELL CLONE ; IN-VITRO ; INHALATION EXPOSURE ; NASAL-MUCOSA ; FORMIC-ACID ; NK CELLS ; EXPRESSION ; IL-4 ; INTERLEUKIN-10
英文摘要

Formaldehyde (FA) is a well-known irritant, and it is suggested to increase the risk of immune diseases and cancer. The present study aimed to evaluate the distribution of major lymphocyte subsets and cytokine expression profiles in the peripheral blood of FA-exposed workers. A total of 118 FA-exposed workers and 79 controls were enrolled in the study. High performance liquid chromatography, flow cytometry, and cytometric bead array were used to analyze FA in air sample and formic acid in urine, blood lymphocyte subpopulations, and serum cytokines, respectively. The FA-exposed workers were divided into low and high exposure groups according to their exposure levels. The results showed that both the low and high FA-exposed groups had a significant increase of formic acid in urine when compared to the controls. Both the low and high exposure groups had a significant increase in the percentage of B cells (CD19(+)) compared to the control group (p<0.01). A significant increase in the percentage of the natural killer (NK) cells (CD56(+)) was observed in the low exposure group compared to the control (p = 0.013). Moreover, the FA-exposed workers in both exposure groups showed a significant higher level of IL-10 but lower level of IL-8 than the control (p<0.01). Subjects in the high exposure group had a higher level of IL-4 but a lower level of IFN-gamma than the control (p<0.05). Finally, there is a significant correlation between the levels of IL-10, IL-4, and IL-8 and formic acid (p<0.05). The findings from the present study may explain, at least in part, the association between FA exposure and immune diseases and cancer.

语种英语
WOS记录号WOS:000341303200008
项目编号81102103 ; 200902006
资助机构National Natural Science Foundation of China ; Key Program of Scientific Research of Public Welfare Project of the Ministry of Health of China
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66961
专题中国药物依赖性研究所
北京大学医学部管理机构_医学部
作者单位1.Chinese Ctr Dis Control & Prevent, Natl Inst Occupat Hlth & Poison Control, Key Lab Chem Safety & Hlth, Beijing, Peoples R China
2.Shandong Acad Occupat Hlth & Occupat Med, Jinan, Shandong, Peoples R China
3.Texas Tech Univ, Inst Environm & Human Hlth, Dept Environm Toxicol, Lubbock, TX 79409 USA
4.Peking Univ, Natl Inst Drug Dependence, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Jia, Xiaowei,Jia, Qiang,Zhang, Zhihu,et al. Effects of Formaldehyde on Lymphocyte Subsets and Cytokines in the Peripheral Blood of Exposed Workers[J]. PLOS ONE,2014,9(8).
APA Jia, Xiaowei.,Jia, Qiang.,Zhang, Zhihu.,Gao, Weimin.,Zhang, Xianan.,...&Zheng, Yuxin.(2014).Effects of Formaldehyde on Lymphocyte Subsets and Cytokines in the Peripheral Blood of Exposed Workers.PLOS ONE,9(8).
MLA Jia, Xiaowei,et al."Effects of Formaldehyde on Lymphocyte Subsets and Cytokines in the Peripheral Blood of Exposed Workers".PLOS ONE 9.8(2014).
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