北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 中国药物依赖性研究所  > 期刊论文
学科主题: 药物依赖
题名:
Effects of Formaldehyde on Lymphocyte Subsets and Cytokines in the Peripheral Blood of Exposed Workers
作者: Jia, Xiaowei1; Jia, Qiang2; Zhang, Zhihu2; Gao, Weimin3; Zhang, Xianan1; Niu, Yong1; Meng, Tao1; Feng, Bin2; Duan, Huawei1; Ye, Meng1; Dai, Yufei1; Jia, Zhongwei4; Zheng, Yuxin1
刊名: PLOS ONE
发表日期: 2014-08-26
DOI: 10.1371/journal.pone.0104069
卷: 9, 期:8
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: CONTACT-DERMATITIS GROUP ; T-CELL CLONE ; IN-VITRO ; INHALATION EXPOSURE ; NASAL-MUCOSA ; FORMIC-ACID ; NK CELLS ; EXPRESSION ; IL-4 ; INTERLEUKIN-10
英文摘要:

Formaldehyde (FA) is a well-known irritant, and it is suggested to increase the risk of immune diseases and cancer. The present study aimed to evaluate the distribution of major lymphocyte subsets and cytokine expression profiles in the peripheral blood of FA-exposed workers. A total of 118 FA-exposed workers and 79 controls were enrolled in the study. High performance liquid chromatography, flow cytometry, and cytometric bead array were used to analyze FA in air sample and formic acid in urine, blood lymphocyte subpopulations, and serum cytokines, respectively. The FA-exposed workers were divided into low and high exposure groups according to their exposure levels. The results showed that both the low and high FA-exposed groups had a significant increase of formic acid in urine when compared to the controls. Both the low and high exposure groups had a significant increase in the percentage of B cells (CD19(+)) compared to the control group (p<0.01). A significant increase in the percentage of the natural killer (NK) cells (CD56(+)) was observed in the low exposure group compared to the control (p = 0.013). Moreover, the FA-exposed workers in both exposure groups showed a significant higher level of IL-10 but lower level of IL-8 than the control (p<0.01). Subjects in the high exposure group had a higher level of IL-4 but a lower level of IFN-gamma than the control (p<0.05). Finally, there is a significant correlation between the levels of IL-10, IL-4, and IL-8 and formic acid (p<0.05). The findings from the present study may explain, at least in part, the association between FA exposure and immune diseases and cancer.

语种: 英语
所属项目编号: 81102103 ; 200902006
项目资助者: National Natural Science Foundation of China ; Key Program of Scientific Research of Public Welfare Project of the Ministry of Health of China
WOS记录号: WOS:000341303200008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66961
Appears in Collections:中国药物依赖性研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Chinese Ctr Dis Control & Prevent, Natl Inst Occupat Hlth & Poison Control, Key Lab Chem Safety & Hlth, Beijing, Peoples R China
2.Shandong Acad Occupat Hlth & Occupat Med, Jinan, Shandong, Peoples R China
3.Texas Tech Univ, Inst Environm & Human Hlth, Dept Environm Toxicol, Lubbock, TX 79409 USA
4.Peking Univ, Natl Inst Drug Dependence, Beijing 100871, Peoples R China

Recommended Citation:
Jia, Xiaowei,Jia, Qiang,Zhang, Zhihu,et al. Effects of Formaldehyde on Lymphocyte Subsets and Cytokines in the Peripheral Blood of Exposed Workers[J]. PLOS ONE,2014,9(8).
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Jia, Xiaowei]'s Articles
[Jia, Qiang]'s Articles
[Zhang, Zhihu]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Jia, Xiaowei]‘s Articles
[Jia, Qiang]‘s Articles
[Zhang, Zhihu]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace