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Plasma Resistin Levels Associate with Risk For Hypertension among Nondiabetic Women
Zhang, Luxia1,3; Curhan, Gary C.; Forman, John P.
刊名JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
2010-07-01
DOI10.1681/ASN.2009101053
21期:7页:1185-1191
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]GLOMERULAR-FILTRATION-RATE ; CIRCULATING RESISTIN ; ADIPONECTIN ; OBESITY ; ADIPOCYTOKINES ; QUESTIONNAIRE ; INFLAMMATION ; DYSFUNCTION ; ACTIVATION ; EXPRESSION
英文摘要

Emerging evidence suggests a role for resistin in inflammation and vascular dysfunction, which may contribute to the pathogenesis of hypertension, but the association between resistin levels and incident hypertension is unknown. We examined the association between plasma resistin levels and the risk for incident hypertension among 872 women without a history of hypertension or diabetes from the Nurses′ Health Study. We identified 361 incident cases of hypertension during 14 years of follow-up. After adjustment for potential confounders, resistin levels in the highest tertile conferred a 75% higher risk for hypertension than the lowest tertile (relative risk [RR] 1.75; 95% confidence interval [Cl] 1.19 to 2.56). Further adjustment for other adipokines did not change the RR substantially. In stratified analysis, resistin levels in the highest tertile significantly increased the risk for hypertension among women aged years (adjusted RR 2.40; 95% Cl 1.55 to 3.73) but not among women aged <55 years (adjusted RR 0.64; 95% Cl 0.25 to 1.62). In a subset analysis of 362 women who also had measurements of inflammatory and endothelial biomarkers, plasma resistin levels significantly correlated with IL-6, soluble TNF receptor 2, intercellular adhesion molecule 1, vascular adhesion molecule 1, and E-selectin after controlling for age and body mass index. After further adjustment for these biomarkers and C-reactive protein, resistin levels remained significantly associated with incident hypertension In conclusion, higher plasma resistin levels independently associate with an increased risk for incident hypertension among women without diabetes.

语种英语
WOS记录号WOS:000280447100019
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被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66964
专题北京大学第一临床医学院_肾脏内科
作者单位1.Harvard Univ, Sch Med, Boston, MA USA
2.Brigham & Womens Hosp, Channing Lab, Dept Med, Div Renal, Boston, MA 02115 USA
3.Peking Univ, Hosp 1, Dept Med, Div Renal, Beijing 100871, Peoples R China
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Zhang, Luxia,Curhan, Gary C.,Forman, John P.. Plasma Resistin Levels Associate with Risk For Hypertension among Nondiabetic Women[J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY,2010,21(7):1185-1191.
APA Zhang, Luxia,Curhan, Gary C.,&Forman, John P..(2010).Plasma Resistin Levels Associate with Risk For Hypertension among Nondiabetic Women.JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY,21(7),1185-1191.
MLA Zhang, Luxia,et al."Plasma Resistin Levels Associate with Risk For Hypertension among Nondiabetic Women".JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 21.7(2010):1185-1191.
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