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学科主题: 临床医学
题名:
Plasma Resistin Levels Associate with Risk For Hypertension among Nondiabetic Women
作者: Zhang, Luxia1,3; Curhan, Gary C.; Forman, John P.
刊名: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
发表日期: 2010-07-01
DOI: 10.1681/ASN.2009101053
卷: 21, 期:7, 页:1185-1191
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: GLOMERULAR-FILTRATION-RATE ; CIRCULATING RESISTIN ; ADIPONECTIN ; OBESITY ; ADIPOCYTOKINES ; QUESTIONNAIRE ; INFLAMMATION ; DYSFUNCTION ; ACTIVATION ; EXPRESSION
英文摘要:

Emerging evidence suggests a role for resistin in inflammation and vascular dysfunction, which may contribute to the pathogenesis of hypertension, but the association between resistin levels and incident hypertension is unknown. We examined the association between plasma resistin levels and the risk for incident hypertension among 872 women without a history of hypertension or diabetes from the Nurses′ Health Study. We identified 361 incident cases of hypertension during 14 years of follow-up. After adjustment for potential confounders, resistin levels in the highest tertile conferred a 75% higher risk for hypertension than the lowest tertile (relative risk [RR] 1.75; 95% confidence interval [Cl] 1.19 to 2.56). Further adjustment for other adipokines did not change the RR substantially. In stratified analysis, resistin levels in the highest tertile significantly increased the risk for hypertension among women aged years (adjusted RR 2.40; 95% Cl 1.55 to 3.73) but not among women aged <55 years (adjusted RR 0.64; 95% Cl 0.25 to 1.62). In a subset analysis of 362 women who also had measurements of inflammatory and endothelial biomarkers, plasma resistin levels significantly correlated with IL-6, soluble TNF receptor 2, intercellular adhesion molecule 1, vascular adhesion molecule 1, and E-selectin after controlling for age and body mass index. After further adjustment for these biomarkers and C-reactive protein, resistin levels remained significantly associated with incident hypertension In conclusion, higher plasma resistin levels independently associate with an increased risk for incident hypertension among women without diabetes.

语种: 英语
所属项目编号: 0535401T ; CA87969 ; HL079929
项目资助者: American Heart Association ; National Institutes of Health ; Beijing Municipal Science and Technology Commission ; International Society of Nephrology
WOS记录号: WOS:000280447100019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66964
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Harvard Univ, Sch Med, Boston, MA USA
2.Brigham & Womens Hosp, Channing Lab, Dept Med, Div Renal, Boston, MA 02115 USA
3.Peking Univ, Hosp 1, Dept Med, Div Renal, Beijing 100871, Peoples R China

Recommended Citation:
Zhang, Luxia,Curhan, Gary C.,Forman, John P.. Plasma Resistin Levels Associate with Risk For Hypertension among Nondiabetic Women[J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY,2010,21(7):1185-1191.
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