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Comparative studies on the transport across human erythrocyte membrane by metal ions Ni2+ and Cd2+ with different configurations of electron
Wu, G; Qiao, XW; Li, RC; Wang, K
关键词metal ions human erythrocyte transmembrane transport
刊名CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
2003-02-01
24期:2页:211-213
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]KINETICS ; COMPLEXES
英文摘要

The rate constants of transmembrane transport of Ni2+ and Cd3+ with the same charge and different configurations of electron were determined in this experiment, and their first-order kinetic rate constant is as follows: for Ni2+, k(Ni2+)= 0. 002 0 h(-1), and for Cd2+, k(Cd2+) = 0. 021 h(-1). There are large differences between their rates of transmemebrane transport. The mechanisms of transmembrane transport of Ni2+ and Cd2+ are studied at the same time. The influences of the concentration of metal ions, pH of solution and the transport inhibitor on the uptake of Ni2+ and Cd2+ by human erythrocytes have been studied. The results show that Ni2+ ions pass through the membrane by passive diffusion, while for Cd2+ some of them are transported by the anion channel, the others by passive diffusion. Because there are different configurations of electron in the two ions, there are large difference in action of them with protein in the membrane of human erythrocytes.

语种中文
WOS记录号WOS:000182543000006
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66970
专题北京大学药学院_化学生物学系
作者单位1.Baotou Med Coll, Dept Chem, Baotou 014010, Peoples R China
2.Shihezi Univ, Normal Sch, Dept Chem, Shihezi 832002, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100083, Peoples R China
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GB/T 7714
Wu, G,Qiao, XW,Li, RC,et al. Comparative studies on the transport across human erythrocyte membrane by metal ions Ni2+ and Cd2+ with different configurations of electron[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2003,24(2):211-213.
APA Wu, G,Qiao, XW,Li, RC,&Wang, K.(2003).Comparative studies on the transport across human erythrocyte membrane by metal ions Ni2+ and Cd2+ with different configurations of electron.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,24(2),211-213.
MLA Wu, G,et al."Comparative studies on the transport across human erythrocyte membrane by metal ions Ni2+ and Cd2+ with different configurations of electron".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 24.2(2003):211-213.
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