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学科主题: 药学
题名:
Comparative studies on the transport across human erythrocyte membrane by metal ions Ni2+ and Cd2+ with different configurations of electron
作者: Wu, G; Qiao, XW; Li, RC; Wang, K
关键词: metal ions ; human erythrocyte ; transmembrane transport
刊名: CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
发表日期: 2003-02-01
卷: 24, 期:2, 页:211-213
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: KINETICS ; COMPLEXES
英文摘要:

The rate constants of transmembrane transport of Ni2+ and Cd3+ with the same charge and different configurations of electron were determined in this experiment, and their first-order kinetic rate constant is as follows: for Ni2+, k(Ni2+)= 0. 002 0 h(-1), and for Cd2+, k(Cd2+) = 0. 021 h(-1). There are large differences between their rates of transmemebrane transport. The mechanisms of transmembrane transport of Ni2+ and Cd2+ are studied at the same time. The influences of the concentration of metal ions, pH of solution and the transport inhibitor on the uptake of Ni2+ and Cd2+ by human erythrocytes have been studied. The results show that Ni2+ ions pass through the membrane by passive diffusion, while for Cd2+ some of them are transported by the anion channel, the others by passive diffusion. Because there are different configurations of electron in the two ions, there are large difference in action of them with protein in the membrane of human erythrocytes.

语种: 中文
WOS记录号: WOS:000182543000006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66970
Appears in Collections:北京大学药学院_化学生物学系_期刊论文

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作者单位: 1.Baotou Med Coll, Dept Chem, Baotou 014010, Peoples R China
2.Shihezi Univ, Normal Sch, Dept Chem, Shihezi 832002, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100083, Peoples R China

Recommended Citation:
Wu, G,Qiao, XW,Li, RC,et al. Comparative studies on the transport across human erythrocyte membrane by metal ions Ni2+ and Cd2+ with different configurations of electron[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2003,24(2):211-213.
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