学科主题 | 基础医学 |
Mutations in preS genes of genotype C hepatitis B virus in patients with chronic hepatitis B and hepatocellular carcinoma | |
Gao, Zhi Yong; Li, Tong; Wang, Jia; Du, Ji Mei; Li, Ya Juan; Li, Jie; Lu, Feng Min; Zhuang, Hui | |
关键词 | hepatitis B virus (HBV) genotype C preS mutation hepatocellular carcinoma (HCC) |
刊名 | JOURNAL OF GASTROENTEROLOGY
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2007-09-01 | |
DOI | 10.1007/s00535-007-2085-1 |
卷 | 42期:9页:761-768 |
收录类别 | SCI |
文章类型 | Article |
WOS标题词 | Science & Technology |
类目[WOS] | Gastroenterology & Hepatology |
研究领域[WOS] | Gastroenterology & Hepatology |
关键词[WOS] | CHRONIC HBV INFECTION ; LIVER-DISEASES ; S REGION ; PHYLOGENETIC RELATEDNESS ; FULMINANT-HEPATITIS ; PROTEIN EXPRESSION ; CHRONIC CARRIERS ; PRE-S(2) REGION ; SURFACE-ANTIGEN ; HIGH PREVALENCE |
英文摘要 | Background. Hepatitis B virus (HBV) preS mutations are frequently isolated from patients with severe forms of liver disease. Meanwhile, genotype C has been shown to cause more serious liver disease than genotype B. This study assesses the frequency of preS mutation in Chinese patients with genotype C chronic HBV infection and its relation to liver damage. Methods. Seventy-nine persistently infected patients (25 asymptomatic carriers, 28 with chronic hepatitis, and 26 with hepatocellular carcinoma) with genotype C HBV were analyzed. Levels of HBV DNA, hepatitis B e antigen (HBeAg), alanine aminotransferase, and aspartate transaminase and mutations in the preS region were determined. Results. The correlations of preS deletion with disease progression were distinct: preS deletion mutations were more commonly found in the hepatocellular carcinoma (HCC) group than in the chronic hepatitis B (CHB) or asymptomatic carrier (ASC) groups, with the frequencies of 38.46% (10/26) in the HCC, 7.14% (2/28) in the CHB, and 4.00% (1/25) in the ASC (P = 0.001) groups. The HBeAg-positive rate and HBV DNA levels were comparable between patients with the preS mutation and those without. Conclusions. PreS deletion mutations of genotype C HBV might play a role in HBV-related hepatocarcinogenesis. |
语种 | 英语 |
WOS记录号 | WOS:000249577300008 |
Citation statistics | |
文献类型 | 期刊论文 |
版本 | 出版稿 |
条目标识符 | http://ir.bjmu.edu.cn/handle/400002259/66973 |
Collection | 北京大学基础医学院_病原生物学系 |
作者单位 | 1.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100083, Peoples R China 2.Wenzhou Med Coll, Sch Lab Med, Wenzhou, Peoples R China |
Recommended Citation GB/T 7714 | Gao, Zhi Yong,Li, Tong,Wang, Jia,et al. Mutations in preS genes of genotype C hepatitis B virus in patients with chronic hepatitis B and hepatocellular carcinoma[J]. JOURNAL OF GASTROENTEROLOGY,2007,42(9):761-768. |
APA | Gao, Zhi Yong.,Li, Tong.,Wang, Jia.,Du, Ji Mei.,Li, Ya Juan.,...&Zhuang, Hui.(2007).Mutations in preS genes of genotype C hepatitis B virus in patients with chronic hepatitis B and hepatocellular carcinoma.JOURNAL OF GASTROENTEROLOGY,42(9),761-768. |
MLA | Gao, Zhi Yong,et al."Mutations in preS genes of genotype C hepatitis B virus in patients with chronic hepatitis B and hepatocellular carcinoma".JOURNAL OF GASTROENTEROLOGY 42.9(2007):761-768. |
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