IR@PKUHSC  > 北京大学基础医学院  > 病原生物学系
学科主题基础医学
Mutations in preS genes of genotype C hepatitis B virus in patients with chronic hepatitis B and hepatocellular carcinoma
Gao, Zhi Yong; Li, Tong; Wang, Jia; Du, Ji Mei; Li, Ya Juan; Li, Jie; Lu, Feng Min; Zhuang, Hui
关键词hepatitis B virus (HBV) genotype C preS mutation hepatocellular carcinoma (HCC)
刊名JOURNAL OF GASTROENTEROLOGY
2007-09-01
DOI10.1007/s00535-007-2085-1
42期:9页:761-768
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]CHRONIC HBV INFECTION ; LIVER-DISEASES ; S REGION ; PHYLOGENETIC RELATEDNESS ; FULMINANT-HEPATITIS ; PROTEIN EXPRESSION ; CHRONIC CARRIERS ; PRE-S(2) REGION ; SURFACE-ANTIGEN ; HIGH PREVALENCE
英文摘要

Background. Hepatitis B virus (HBV) preS mutations are frequently isolated from patients with severe forms of liver disease. Meanwhile, genotype C has been shown to cause more serious liver disease than genotype B. This study assesses the frequency of preS mutation in Chinese patients with genotype C chronic HBV infection and its relation to liver damage. Methods. Seventy-nine persistently infected patients (25 asymptomatic carriers, 28 with chronic hepatitis, and 26 with hepatocellular carcinoma) with genotype C HBV were analyzed. Levels of HBV DNA, hepatitis B e antigen (HBeAg), alanine aminotransferase, and aspartate transaminase and mutations in the preS region were determined. Results. The correlations of preS deletion with disease progression were distinct: preS deletion mutations were more commonly found in the hepatocellular carcinoma (HCC) group than in the chronic hepatitis B (CHB) or asymptomatic carrier (ASC) groups, with the frequencies of 38.46% (10/26) in the HCC, 7.14% (2/28) in the CHB, and 4.00% (1/25) in the ASC (P = 0.001) groups. The HBeAg-positive rate and HBV DNA levels were comparable between patients with the preS mutation and those without. Conclusions. PreS deletion mutations of genotype C HBV might play a role in HBV-related hepatocarcinogenesis.

语种英语
WOS记录号WOS:000249577300008
Citation statistics
Cited Times:35[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66973
Collection北京大学基础医学院_病原生物学系
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100083, Peoples R China
2.Wenzhou Med Coll, Sch Lab Med, Wenzhou, Peoples R China
Recommended Citation
GB/T 7714
Gao, Zhi Yong,Li, Tong,Wang, Jia,et al. Mutations in preS genes of genotype C hepatitis B virus in patients with chronic hepatitis B and hepatocellular carcinoma[J]. JOURNAL OF GASTROENTEROLOGY,2007,42(9):761-768.
APA Gao, Zhi Yong.,Li, Tong.,Wang, Jia.,Du, Ji Mei.,Li, Ya Juan.,...&Zhuang, Hui.(2007).Mutations in preS genes of genotype C hepatitis B virus in patients with chronic hepatitis B and hepatocellular carcinoma.JOURNAL OF GASTROENTEROLOGY,42(9),761-768.
MLA Gao, Zhi Yong,et al."Mutations in preS genes of genotype C hepatitis B virus in patients with chronic hepatitis B and hepatocellular carcinoma".JOURNAL OF GASTROENTEROLOGY 42.9(2007):761-768.
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