北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 病原生物学系  > 期刊论文
学科主题: 基础医学
题名:
Mutations in preS genes of genotype C hepatitis B virus in patients with chronic hepatitis B and hepatocellular carcinoma
作者: Gao, Zhi Yong; Li, Tong; Wang, Jia; Du, Ji Mei; Li, Ya Juan; Li, Jie; Lu, Feng Min; Zhuang, Hui
关键词: hepatitis B virus (HBV) ; genotype C ; preS ; mutation ; hepatocellular carcinoma (HCC)
刊名: JOURNAL OF GASTROENTEROLOGY
发表日期: 2007-09-01
DOI: 10.1007/s00535-007-2085-1
卷: 42, 期:9, 页:761-768
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: CHRONIC HBV INFECTION ; LIVER-DISEASES ; S REGION ; PHYLOGENETIC RELATEDNESS ; FULMINANT-HEPATITIS ; PROTEIN EXPRESSION ; CHRONIC CARRIERS ; PRE-S(2) REGION ; SURFACE-ANTIGEN ; HIGH PREVALENCE
英文摘要:

Background. Hepatitis B virus (HBV) preS mutations are frequently isolated from patients with severe forms of liver disease. Meanwhile, genotype C has been shown to cause more serious liver disease than genotype B. This study assesses the frequency of preS mutation in Chinese patients with genotype C chronic HBV infection and its relation to liver damage. Methods. Seventy-nine persistently infected patients (25 asymptomatic carriers, 28 with chronic hepatitis, and 26 with hepatocellular carcinoma) with genotype C HBV were analyzed. Levels of HBV DNA, hepatitis B e antigen (HBeAg), alanine aminotransferase, and aspartate transaminase and mutations in the preS region were determined. Results. The correlations of preS deletion with disease progression were distinct: preS deletion mutations were more commonly found in the hepatocellular carcinoma (HCC) group than in the chronic hepatitis B (CHB) or asymptomatic carrier (ASC) groups, with the frequencies of 38.46% (10/26) in the HCC, 7.14% (2/28) in the CHB, and 4.00% (1/25) in the ASC (P = 0.001) groups. The HBeAg-positive rate and HBV DNA levels were comparable between patients with the preS mutation and those without. Conclusions. PreS deletion mutations of genotype C HBV might play a role in HBV-related hepatocarcinogenesis.

语种: 英语
WOS记录号: WOS:000249577300008
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66973
Appears in Collections:基础医学院_病原生物学系_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
Mutations in preS genes of genotype C hepatitis B virus in patients with chronic hepatitis B and hepatocellular carcinoma.pdf(158KB)期刊论文出版稿限制开放 联系获取全文

作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100083, Peoples R China
2.Wenzhou Med Coll, Sch Lab Med, Wenzhou, Peoples R China

Recommended Citation:
Gao, Zhi Yong,Li, Tong,Wang, Jia,et al. Mutations in preS genes of genotype C hepatitis B virus in patients with chronic hepatitis B and hepatocellular carcinoma[J]. JOURNAL OF GASTROENTEROLOGY,2007,42(9):761-768.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Gao, Zhi Yong]'s Articles
[Li, Tong]'s Articles
[Wang, Jia]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Gao, Zhi Yong]‘s Articles
[Li, Tong]‘s Articles
[Wang, Jia]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace