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学科主题: 基础医学
题名:
Mutations in preS genes of genotype C hepatitis B virus in patients with chronic hepatitis B and hepatocellular carcinoma
作者: Gao, Zhi Yong; Li, Tong; Wang, Jia; Du, Ji Mei; Li, Ya Juan; Li, Jie; Lu, Feng Min; Zhuang, Hui
关键词: hepatitis B virus (HBV) ; genotype C ; preS ; mutation ; hepatocellular carcinoma (HCC)
刊名: JOURNAL OF GASTROENTEROLOGY
发表日期: 2007-09-01
DOI: 10.1007/s00535-007-2085-1
卷: 42, 期:9, 页:761-768
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: CHRONIC HBV INFECTION ; LIVER-DISEASES ; S REGION ; PHYLOGENETIC RELATEDNESS ; FULMINANT-HEPATITIS ; PROTEIN EXPRESSION ; CHRONIC CARRIERS ; PRE-S(2) REGION ; SURFACE-ANTIGEN ; HIGH PREVALENCE
英文摘要:

Background. Hepatitis B virus (HBV) preS mutations are frequently isolated from patients with severe forms of liver disease. Meanwhile, genotype C has been shown to cause more serious liver disease than genotype B. This study assesses the frequency of preS mutation in Chinese patients with genotype C chronic HBV infection and its relation to liver damage. Methods. Seventy-nine persistently infected patients (25 asymptomatic carriers, 28 with chronic hepatitis, and 26 with hepatocellular carcinoma) with genotype C HBV were analyzed. Levels of HBV DNA, hepatitis B e antigen (HBeAg), alanine aminotransferase, and aspartate transaminase and mutations in the preS region were determined. Results. The correlations of preS deletion with disease progression were distinct: preS deletion mutations were more commonly found in the hepatocellular carcinoma (HCC) group than in the chronic hepatitis B (CHB) or asymptomatic carrier (ASC) groups, with the frequencies of 38.46% (10/26) in the HCC, 7.14% (2/28) in the CHB, and 4.00% (1/25) in the ASC (P = 0.001) groups. The HBeAg-positive rate and HBV DNA levels were comparable between patients with the preS mutation and those without. Conclusions. PreS deletion mutations of genotype C HBV might play a role in HBV-related hepatocarcinogenesis.

语种: 英语
WOS记录号: WOS:000249577300008
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66973
Appears in Collections:基础医学院_病原生物学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100083, Peoples R China
2.Wenzhou Med Coll, Sch Lab Med, Wenzhou, Peoples R China

Recommended Citation:
Gao, Zhi Yong,Li, Tong,Wang, Jia,et al. Mutations in preS genes of genotype C hepatitis B virus in patients with chronic hepatitis B and hepatocellular carcinoma[J]. JOURNAL OF GASTROENTEROLOGY,2007,42(9):761-768.
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