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学科主题: 精神卫生
题名:
LONG-TERM EFFECTS OF NEONATAL EXPOSURE TO MK-801 ON RECOGNITION MEMORY AND EXCITATORY-INHIBITORY BALANCE IN RAT HIPPOCAMPUS
作者: Li, J. -T.1,2; Zhao, Y. -Y.3; Wang, H. -L.1,2; Wang, X. -D.4; Su, Y. -A.1,2; Si, T. -M.1,2
关键词: cognition ; parvalbumin ; schizophrenia ; VGLUT1 ; VGAT
刊名: NEUROSCIENCE
发表日期: 2015-11-12
DOI: 10.1016/j.neuroscience.2015.09.003
卷: 308, 页:134-143
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: VESICULAR GABA TRANSPORTER ; MEDIAL PREFRONTAL CORTEX ; POSTNATAL-DEVELOPMENT ; CEREBRAL-CORTEX ; NEURODEVELOPMENTAL MODEL ; GABAERGIC INTERNEURONS ; OBJECT RECOGNITION ; COGNITIVE DEFICITS ; WORKING-MEMORY ; TEMPORAL-LOBE
英文摘要:

Blockade of the N-methyl-D-aspartate receptors (NMDARs) during the neonatal period has been reported to induce long-term behavioral and neurochemical alterations that are relevant to schizophrenia. In this study, we examined the effects of such treatment on recognition memory and hippocampal excitatory and inhibitory (E/I) balance in both adolescence and adulthood. After exposure to the NMDAR antagonist, MK-801, at postnatal days (PND) 5-14, male Sprague-Dawley rats were tested for object and object-in-context recognition memory during adolescence (PND 35) and adulthood (PND 63). The parvalbumin-positive (PV+) gamma-aminobutyric acid (GABA)-ergic interneurons and presynaptic markers for excitatory and inhibitory neurons, vesicular glutamate transporter-1 (VGLUT1) and vesicular GABA transporter (VGAT) were examined in the hippocampus to reflect the Ell balance. We found that rats receiving MK-801 treatment showed deficits of recognition memory, reduction in PV+ cell counts and upregulation of the VGLUT1/VGAT ratio in both adolescence and adulthood. Notably, the changes of the VGLUT1/VGAT ratio at the two time points exhibited distinct mechanisms. These results parallel findings of hippocampal abnormalities in schizophrenia and lend support to the usefulness of neonatal NMDAR blockade as a potential neurodevelopmental model for the disease. (C) 2015 IBRO. Published by Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 81171284 ; 81401129 ; 20120001110046 ; 20130001120118
项目资助者: National Natural Science Foundation of China ; Research Fund for the Doctoral Program of Higher Education of China
WOS记录号: WOS:000363599200010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66974
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Hosp 6, Inst Mental Hlth, Natl Clin Res Ctr Mental Disorders, Beijing 100191, Peoples R China
2.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100191, Peoples R China
3.Capital Med Univ, Beijing Anding Hosp, Depress Treatment Ctr, Beijing 100088, Peoples R China
4.Zhejiang Univ, Sch Med, Zhejiang Prov Key Lab Neurobiol, Dept Neurobiol,Key Lab Med Neurobiol,Minist Hlth, Hangzhou 310058, Zhejiang, Peoples R China

Recommended Citation:
Li, J. -T.,Zhao, Y. -Y.,Wang, H. -L.,et al. LONG-TERM EFFECTS OF NEONATAL EXPOSURE TO MK-801 ON RECOGNITION MEMORY AND EXCITATORY-INHIBITORY BALANCE IN RAT HIPPOCAMPUS[J]. NEUROSCIENCE,2015,308:134-143.
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