北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学精神卫生研究所  > 期刊论文
学科主题: 精神卫生
题名:
LONG-TERM EFFECTS OF NEONATAL EXPOSURE TO MK-801 ON RECOGNITION MEMORY AND EXCITATORY-INHIBITORY BALANCE IN RAT HIPPOCAMPUS
作者: Li, J. -T.1,2; Zhao, Y. -Y.3; Wang, H. -L.1,2; Wang, X. -D.4; Su, Y. -A.1,2; Si, T. -M.1,2
关键词: cognition ; parvalbumin ; schizophrenia ; VGLUT1 ; VGAT
刊名: NEUROSCIENCE
发表日期: 2015-11-12
DOI: 10.1016/j.neuroscience.2015.09.003
卷: 308, 页:134-143
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: VESICULAR GABA TRANSPORTER ; MEDIAL PREFRONTAL CORTEX ; POSTNATAL-DEVELOPMENT ; CEREBRAL-CORTEX ; NEURODEVELOPMENTAL MODEL ; GABAERGIC INTERNEURONS ; OBJECT RECOGNITION ; COGNITIVE DEFICITS ; WORKING-MEMORY ; TEMPORAL-LOBE
英文摘要:

Blockade of the N-methyl-D-aspartate receptors (NMDARs) during the neonatal period has been reported to induce long-term behavioral and neurochemical alterations that are relevant to schizophrenia. In this study, we examined the effects of such treatment on recognition memory and hippocampal excitatory and inhibitory (E/I) balance in both adolescence and adulthood. After exposure to the NMDAR antagonist, MK-801, at postnatal days (PND) 5-14, male Sprague-Dawley rats were tested for object and object-in-context recognition memory during adolescence (PND 35) and adulthood (PND 63). The parvalbumin-positive (PV+) gamma-aminobutyric acid (GABA)-ergic interneurons and presynaptic markers for excitatory and inhibitory neurons, vesicular glutamate transporter-1 (VGLUT1) and vesicular GABA transporter (VGAT) were examined in the hippocampus to reflect the Ell balance. We found that rats receiving MK-801 treatment showed deficits of recognition memory, reduction in PV+ cell counts and upregulation of the VGLUT1/VGAT ratio in both adolescence and adulthood. Notably, the changes of the VGLUT1/VGAT ratio at the two time points exhibited distinct mechanisms. These results parallel findings of hippocampal abnormalities in schizophrenia and lend support to the usefulness of neonatal NMDAR blockade as a potential neurodevelopmental model for the disease. (C) 2015 IBRO. Published by Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 81171284 ; 81401129 ; 20120001110046 ; 20130001120118
项目资助者: National Natural Science Foundation of China ; Research Fund for the Doctoral Program of Higher Education of China
WOS记录号: WOS:000363599200010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66974
Appears in Collections:北京大学精神卫生研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Hosp 6, Inst Mental Hlth, Natl Clin Res Ctr Mental Disorders, Beijing 100191, Peoples R China
2.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100191, Peoples R China
3.Capital Med Univ, Beijing Anding Hosp, Depress Treatment Ctr, Beijing 100088, Peoples R China
4.Zhejiang Univ, Sch Med, Zhejiang Prov Key Lab Neurobiol, Dept Neurobiol,Key Lab Med Neurobiol,Minist Hlth, Hangzhou 310058, Zhejiang, Peoples R China

Recommended Citation:
Li, J. -T.,Zhao, Y. -Y.,Wang, H. -L.,et al. LONG-TERM EFFECTS OF NEONATAL EXPOSURE TO MK-801 ON RECOGNITION MEMORY AND EXCITATORY-INHIBITORY BALANCE IN RAT HIPPOCAMPUS[J]. NEUROSCIENCE,2015,308:134-143.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Li, J. -T.]'s Articles
[Zhao, Y. -Y.]'s Articles
[Wang, H. -L.]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Li, J. -T.]‘s Articles
[Zhao, Y. -Y.]‘s Articles
[Wang, H. -L.]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace