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Differentiation of Herba Cistanches by fingerprint with high-performance liquid chromatography-diode array detection-mass spectrometry
Jiang, Y.1; Li, S. R.2; Wang, Y. T.2; Chen, X. J.2; Tu, P. F.1
关键词Herba Cistanches Source differentiation Fingerprint HPLC-DAD-MS Quality control
刊名JOURNAL OF CHROMATOGRAPHY A
2009-03-13
DOI10.1016/j.chroma.2008.04.040
1216期:11页:2156-2162
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]PHENYLETHANOID GLYCOSIDES ; QUALITY-CONTROL ; CONSTITUENTS ; TUBULOSA
英文摘要

Herba Cistanche (Rou Cong Rang in Chinese), dried succulent stems of Cistanche deserticola or C. tubulosa, is a famous Chinese herbal medicine and has been recorded in the Chinese Pharmacopoeia. In recent years, another two non-official species, C. salsa and C. sinensis have also been used as Herba Cistanche in some regions of China. To investigate the possibility Of using these two non-official species as alternatives to the official species, a high-performance liquid chromatography-diode array detection-mass spectrometry (HPLC-DAD-MS) fingerprint method was developed to comparatively analyze the crude herbs of these four species. The fingerprint of C. deserticola, a historically certified species of Herba Cistanche, serves as ′standard pattern′ for comparing the similarities with the other species by means of similarity and Principle Component Analysis. Additionally, 18 characteristic peaks in the fingerprints were identified by comparing their retention times, UV spectra and ESI-MS data with those of the reference substances and/or the data in the literatures. The comparative results demonstrate that the fingerprints of C. tubulosa and C. salsa possess high similarity to the standard pattern, Suggesting that these two species may be used as alternative species; while that of C. sinensis has low similarity (0.053 correlation coefficient) to the standard pattern, indicating that it cannot be used as the substitute of the official herb. However, the varying fingerprint patterns among the samples of C. deserticola collected from various habitats illustrate that the quality consistency of crude herbs is still a problem worthy of serious concern. (C) 2008 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000264226500024
项目编号985-2-102-113
资助机构New-Century Talent Program, Ministry of Education of China
引用统计
被引频次:56[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66975
专题北京大学药学院
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Beijing 100871, Peoples R China
2.Univ Macau, Inst Chinese Med Sci, Taipa, Macau, Peoples R China
推荐引用方式
GB/T 7714
Jiang, Y.,Li, S. R.,Wang, Y. T.,et al. Differentiation of Herba Cistanches by fingerprint with high-performance liquid chromatography-diode array detection-mass spectrometry[J]. JOURNAL OF CHROMATOGRAPHY A,2009,1216(11):2156-2162.
APA Jiang, Y.,Li, S. R.,Wang, Y. T.,Chen, X. J.,&Tu, P. F..(2009).Differentiation of Herba Cistanches by fingerprint with high-performance liquid chromatography-diode array detection-mass spectrometry.JOURNAL OF CHROMATOGRAPHY A,1216(11),2156-2162.
MLA Jiang, Y.,et al."Differentiation of Herba Cistanches by fingerprint with high-performance liquid chromatography-diode array detection-mass spectrometry".JOURNAL OF CHROMATOGRAPHY A 1216.11(2009):2156-2162.
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