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学科主题: 临床医学
题名:
Prevalence and clinical significance of BRAF V600E in Chinese patients with lung adenocarcinoma
作者: Li, Zhenxiang; Jiang, Leilei; Bai, Hua; Wang, Zhijie; Zhao, Jun; Duan, Jianchun; Yang, Xiaodan; An, Tongtong; Wang, Jie
关键词: BRAF mutation ; EGFR mutation ; lung adenocarcinomas ; plasma DNA
刊名: THORACIC CANCER
发表日期: 2015-05-01
DOI: 10.1111/1759-7714.12177
卷: 6, 期:3, 页:269-274
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Respiratory System
研究领域[WOS]: Oncology ; Respiratory System
关键词[WOS]: FACTOR RECEPTOR MUTATIONS ; CANCER ; EGFR ; KRAS ; MANAGEMENT ; MELANOMA ; FEATURES
英文摘要:

BackgroundThe purpose of this study was to investigate the prevalence, distribution, and prognostic role of v-raf murine sarcoma viral oncogene homolog B (BRAF) V600E mutations in Chinese patients with lung adenocarcinoma (ADC), and to explore the possibility of BRAF V600E mutation detection in plasma DNA.

MethodsData from 190 patients with lung ADCs treated at the Peking University Cancer Hospital from July 2011 to March 2012 were collected. The amplification refractory mutation system was used for BRAF V600E testing and denaturing high-performance liquid chromatography for epidermal growth factor receptor (EGFR) mutation detection. In BRAF V600E-mutant cases, paired plasma DNA was tested for mutation status of BRAF V600E and EGFR. The distribution and prognostic role of BRAF V600E mutations were analyzed using SPSS 13.0.

ResultsAmong 190 patients with advanced lung ADC, eight (4.2%) cases carried BRAF V600E mutations. V600E mutations presented more frequently in women than in men (6 of 96, 6.3% vs. P = 0.1). BRAF and EGFR mutations were concomitantly presented in three patients. Five of the eight patients with BRAF V600E mutations had matched plasma DNA samples and V600E mutations were found in three plasma samples.

ConclusionThe prevalence of BRAF V600E mutations in Chinese patients with lung ADC is 4.2%. Circulating plasma DNA may be used for BRAF V600E mutation analysis in lung adenocarcinoma.

语种: 英语
所属项目编号: 81025012 ; 81172235 ; 2007-1023 ; 2011-2-22 ; Z090507017709015
项目资助者: National Natural Sciences Foundation Distinguished Young Scholars Program ; National Natural Sciences Foundation General Program ; Capital Development Foundation ; Beijing Health Systems Academic Leader Program ; Science and Technology Project of Beijing
WOS记录号: WOS:000353922500006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66982
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: Peking Univ, Sch Oncol, Dept Thorac Med Oncol,Minist Educ, Beijing Canc Hosp & Inst,Key Lab Carcinogenesis &, Beijing 100036, Peoples R China

Recommended Citation:
Li, Zhenxiang,Jiang, Leilei,Bai, Hua,et al. Prevalence and clinical significance of BRAF V600E in Chinese patients with lung adenocarcinoma[J]. THORACIC CANCER,2015,6(3):269-274.
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