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学科主题: 临床医学
题名:
Novel expression profiles and invasiveness-related biology function of DKK1 in endometrial carcinoma
作者: Yi, Nuo1; Liao, Qin-Ping1; Li, Ting2; Xiong, Yan2
关键词: DKK1 ; endometrial carcinoma ; benign endometrium ; invasiveness
刊名: ONCOLOGY REPORTS
发表日期: 2009-06-01
DOI: 10.3892/or_00000370
卷: 21, 期:6, 页:1421-1427
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: WNT SIGNALING PATHWAY ; FREQUENT EPIGENETIC INACTIVATION ; SQUAMOUS-CELL CARCINOMA ; CANCER-CELLS ; ACTIVATION ; INVASION ; TARGET ; INHIBITION ; NEOPLASIA ; MECHANISM
英文摘要:

DKK1 is a negative regulator in the Wnt signal transduction pathway. It can inhibit the pathway′s activation. Previous studies in some malignant tumors revealed the possibility that DKK1 is involved in tumorigenesis inducing abnormalities of the Writ signal pathway. In this study, we showed that in benign and malignant endometrium, DKK1 exhibited novel expression profiles and invasiveness-related biology function: DKK1 was expressed in both glandular epithelium and matrix of two kinds of endometrium tissues and mostly distributed in the cytoplasm and epicytes of endometrial carcinoma (EC) Ishikawa cell line. DKK1 expression level in EC was significantly lower than that in benign endometrium. The expression correlated well with histology and clinical stage of EC. Exogenous DKK1 suppressed invasiveness of EC cells. Taken together, DKK1 is involved in genesis and early phase of EC by suppressing the invasiveness via the Writ signal pathway. It shows promise as a biomarker for screening the progression of EC.

语种: 英语
WOS记录号: WOS:000266185900010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66989
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Obstet & Gynecol, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Dept Pathol, Beijing 100034, Peoples R China

Recommended Citation:
Yi, Nuo,Liao, Qin-Ping,Li, Ting,et al. Novel expression profiles and invasiveness-related biology function of DKK1 in endometrial carcinoma[J]. ONCOLOGY REPORTS,2009,21(6):1421-1427.
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