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学科主题: 临床医学
题名:
Some Problems of Nanomaterials in Bioanalytical Applications
作者: Song Yanchao1; Liu Junxiu2; Zhang Yangyang1; Shi Wen1; Ma Huimin1
关键词: nanomaterials ; CdTe quantum dots ; Au nanoparticles ; carbon nanodots ; toxicity ; microscopic heterogeneity ; environmental susceptivity ; bioanalysis
刊名: ACTA CHIMICA SINICA
发表日期: 2013-12-15
DOI: 10.6023/A13080904
卷: 71, 期:12, 页:1607-1610
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: CDTE QUANTUM DOTS ; GOLD NANOPARTICLES ; CARBON NANODOTS ; DRUG-DELIVERY ; CELLS ; ACID ; CYTOTOXICITY ; NANOPROBE ; SENSOR ; IONS
英文摘要:

By taking the three commonly used CdTe quantum dots (CdTe QDs), Au nanoparticles (Au NPs) and carbon nanodots (C-dots) as example, we have demonstrated and summarized some noteworthy problems of nanomaterials in bio-analytical applications. These problems mainly include the toxicity, microscopic heterogeneity and environmental susceptivity of nanomaterials, which had been separately discussed with different depths but unfortunately are often overlooked in practice. In the present work, a parallel comparative investigation was first made on cytotoxicity, which reveals that CdTe QDs can lead to the decrease of cell metabolic activity, cell shrinkage, and even cell death; Au NPs at a higher concentration (30 mu g/mL) decrease the metabolic activity of cells to a small extent; C-dots exert no obvious toxicity to live cells, showing good biocompatibility. These studies indicate that the relative toxicity of the three nanomaterials in their bare forms is CdTe QDs>>AuNPs>C-dots, which is further supported by the inhibition experiment on the growth of green gram sprouts. Second, the microscopic heterogeneity of nanomaterials was compared with that of resorufin (a small molecular fluorescent dye) by cell imaging experiments, which clearly shows that the distribution of nanomaterials in cells is much less uniform than that of small molecular probes. Besides, the heterogeneity of both size distribution and surface modification/property of nanomaterials is also unavoidable. Third, the environmental susceptivity of nanomaterials was studied, and the results showed that spectroscopic properties of the above three nanomaterials are all sensitive to the pH change of solution. Moreover, AuNPs are also rather susceptible to the ionic strength of solution. The above three problems should arouse high attention of researchers in some bioanalyses. In addition, the measures that we suggested in the paper may be helpful to solve these problems to some extent.

语种: 中文
所属项目编号: 21321003 ; 2011CB935800 ; 2010CB933502
项目资助者: National Natural Science Foundation of China ; 973 Program ; Chinese Academy of Sciences
WOS记录号: WOS:000329892400005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66990
Appears in Collections:北京大学第三临床医学院_耳鼻喉科_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Chem, Key Lab Analyt Chem Living Biosyst, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
2.Peking Univ, Hosp 3, Dept Otorhinolaryngol, Beijing 100191, Peoples R China

Recommended Citation:
Song Yanchao,Liu Junxiu,Zhang Yangyang,et al. Some Problems of Nanomaterials in Bioanalytical Applications[J]. ACTA CHIMICA SINICA,2013,71(12):1607-1610.
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