IR@PKUHSC  > 北京大学第三临床医学院  > 耳鼻喉科
学科主题临床医学
Some Problems of Nanomaterials in Bioanalytical Applications
Song Yanchao1; Liu Junxiu2; Zhang Yangyang1; Shi Wen1; Ma Huimin1
关键词nanomaterials CdTe quantum dots Au nanoparticles carbon nanodots toxicity microscopic heterogeneity environmental susceptivity bioanalysis
刊名ACTA CHIMICA SINICA
2013-12-15
DOI10.6023/A13080904
71期:12页:1607-1610
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary
资助者National Natural Science Foundation of China ; 973 Program ; Chinese Academy of Sciences ; National Natural Science Foundation of China ; 973 Program ; Chinese Academy of Sciences
研究领域[WOS]Chemistry
关键词[WOS]CDTE QUANTUM DOTS ; GOLD NANOPARTICLES ; CARBON NANODOTS ; DRUG-DELIVERY ; CELLS ; ACID ; CYTOTOXICITY ; NANOPROBE ; SENSOR ; IONS
英文摘要

By taking the three commonly used CdTe quantum dots (CdTe QDs), Au nanoparticles (Au NPs) and carbon nanodots (C-dots) as example, we have demonstrated and summarized some noteworthy problems of nanomaterials in bio-analytical applications. These problems mainly include the toxicity, microscopic heterogeneity and environmental susceptivity of nanomaterials, which had been separately discussed with different depths but unfortunately are often overlooked in practice. In the present work, a parallel comparative investigation was first made on cytotoxicity, which reveals that CdTe QDs can lead to the decrease of cell metabolic activity, cell shrinkage, and even cell death; Au NPs at a higher concentration (30 mu g/mL) decrease the metabolic activity of cells to a small extent; C-dots exert no obvious toxicity to live cells, showing good biocompatibility. These studies indicate that the relative toxicity of the three nanomaterials in their bare forms is CdTe QDs>>AuNPs>C-dots, which is further supported by the inhibition experiment on the growth of green gram sprouts. Second, the microscopic heterogeneity of nanomaterials was compared with that of resorufin (a small molecular fluorescent dye) by cell imaging experiments, which clearly shows that the distribution of nanomaterials in cells is much less uniform than that of small molecular probes. Besides, the heterogeneity of both size distribution and surface modification/property of nanomaterials is also unavoidable. Third, the environmental susceptivity of nanomaterials was studied, and the results showed that spectroscopic properties of the above three nanomaterials are all sensitive to the pH change of solution. Moreover, AuNPs are also rather susceptible to the ionic strength of solution. The above three problems should arouse high attention of researchers in some bioanalyses. In addition, the measures that we suggested in the paper may be helpful to solve these problems to some extent.

语种中文
所属项目编号21321003 ; 2011CB935800 ; 2010CB933502
资助者National Natural Science Foundation of China ; 973 Program ; Chinese Academy of Sciences ; National Natural Science Foundation of China ; 973 Program ; Chinese Academy of Sciences
WOS记录号WOS:000329892400005
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66990
Collection北京大学第三临床医学院_耳鼻喉科
作者单位1.Chinese Acad Sci, Inst Chem, Key Lab Analyt Chem Living Biosyst, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
2.Peking Univ, Hosp 3, Dept Otorhinolaryngol, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Song Yanchao,Liu Junxiu,Zhang Yangyang,et al. Some Problems of Nanomaterials in Bioanalytical Applications[J]. ACTA CHIMICA SINICA,2013,71(12):1607-1610.
APA Song Yanchao,Liu Junxiu,Zhang Yangyang,Shi Wen,&Ma Huimin.(2013).Some Problems of Nanomaterials in Bioanalytical Applications.ACTA CHIMICA SINICA,71(12),1607-1610.
MLA Song Yanchao,et al."Some Problems of Nanomaterials in Bioanalytical Applications".ACTA CHIMICA SINICA 71.12(2013):1607-1610.
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