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学科主题: 口腔医学
题名:
In vitro aging of mineralized collagen-based composite as guided tissue regeneration membrane
作者: Pan, SX; Li, Y; Feng, HL; Bai, W; Gu, YY
关键词: guided tissue regeneration (GTR) ; nano-hydroxyapatite ; collagen ; in vitro aging
刊名: MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS
发表日期: 2006-05-01
DOI: 10.1016/j.msec.2005.09.103
卷: 26, 期:4, 页:724-729
收录类别: ISTP ; SCI
文章类型: Proceedings Paper
WOS标题词: Science & Technology
类目[WOS]: Materials Science, Multidisciplinary
研究领域[WOS]: Materials Science
关键词[WOS]: SCAFFOLDS ; CULTURE ; ACID)
英文摘要:

The technique of guided tissue regeneration (GTR) has been developed for the regeneration of periodontal tissues, bone around natural teeth and dental implants. The aim of this study is to investigate the biodegradability and mechanic behavior of a novel mineralized nanohydroxyapatite/collagen/poly (lactic acid) (nHAC/PLA) composite as GTR membrane in vitro. The elastic modulus and maximum tensile strength of GTR film samples with different nHAC/PLA ratio were measured to get an optimal nHAC/PLA ratio. Thermogravimetric analysis was conducted to evaluate the change of the inorganic component in the samples during the process of in vitro aging. Morphology of samples was checked by using scanning electron microscopy. On the basis of the above results, it can be concluded that the GTR membranes maintained integrity and the original appearance throughout the 1-month in vitro aging. There is an active dissolution and deposition process of crystals which is propitious to the bone formation on the surface of the composite membrane. The optimal nHAC/PLA ratio of the novel membrane is 0.4:1. For a longer period of bone repair, PLA with higher molecular weight should be chosen as the scaffold for the GTR membrane. (c) 2005 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000237640800031
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66997
Appears in Collections:北京大学口腔医学院_口腔修复科_期刊论文

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作者单位: 1.Peking Univ, Sch Stomatol, Dept Prosthodont, Beijing 100875, Peoples R China
2.Tsing Hua Univ, Dept Mat Sci & Engn, Beijing 100084, Peoples R China

Recommended Citation:
Pan, SX,Li, Y,Feng, HL,et al. In vitro aging of mineralized collagen-based composite as guided tissue regeneration membrane[J]. MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS,2006,26(4):724-729.
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