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学科主题: 临床医学
题名:
MicroRNA-215 inhibits relapse of colorectal cancer patients following radical surgery
作者: Li, Shan1,2; Gao, Jing1; Gu, Jin3; Yuan, Jiajia1; Hua, Dong4; Shen, Lin1
关键词: miR-215 ; Colorectal cancer ; Relapse ; 5-FU ; Adjuvant chemotherapy
刊名: MEDICAL ONCOLOGY
发表日期: 2013-06-01
DOI: 10.1007/s12032-013-0549-0
卷: 30, 期:2
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: II COLON-CANCER ; CELL-CYCLE ; MIR-215 ; RECURRENCE ; EXPRESSION ; RISK
英文摘要:

To investigate the role of miR-215 in the relapse following radical surgery of colorectal cancer patients. The clinical data and surgical frozen tumor tissues were retrospectively collected from 125 stage II/III colorectal cancer patients, which contained 60 patients who relapsed and 65 patients who did not relapse within 3 years after surgery. The expression of miR-215 was determined by real-time PCR, and the relationship between miR-215 expression and the relapse was analyzed statistically. miR-215 was downregulated in relapsed patients compared to nonrelapsed patients (P = 0.001). The low expression of miR-215 was significantly correlated with a high probability of 3-year relapse (P = 0.001), which was more obvious in stage III patients P < 0.001). The multivariate analysis showed that miR-215 expression could function as an independent predictive marker for relapse. It seemed that patients with high expressions of miR-215 could benefit from 5-fluorouracilcontaining adjuvant chemotherapy without significant difference, whereas this phenomenon was reverse in patients with low expressions of miR-215. Our study highlighted for the first time that miR-215 could function as a potential predictive marker for relapse following radical surgery of colorectal cancer, and the possible correlation between miR215 and 5-fluorouracil-containing adjuvant chemotherapy would be validated in the future.

语种: 英语
所属项目编号: 81172110 ; 2006AA 02A 402-B02 ; 2012AA 02A 504
项目资助者: National Natural Science Foundation of China ; National High Technology Research and Development Program
WOS记录号: WOS:000319450400057
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67002
Appears in Collections:北京大学临床肿瘤学院_胃肠肿瘤中心_期刊论文

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作者单位: 1.Peking Univ, Canc Hosp & Inst, Dept GI Oncol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
2.Capital Med Univ, Beijing Shijitan Hosp, Beijing, Peoples R China
3.Peking Univ, Canc Hosp & Inst, Dept Colorectal Surg, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
4.Fourth Peoples Hosp Wuxi, Dept Med Oncol, Wuxi, Peoples R China

Recommended Citation:
Li, Shan,Gao, Jing,Gu, Jin,et al. MicroRNA-215 inhibits relapse of colorectal cancer patients following radical surgery[J]. MEDICAL ONCOLOGY,2013,30(2).
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