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学科主题临床医学
MicroRNA-215 inhibits relapse of colorectal cancer patients following radical surgery
Li, Shan1,2; Gao, Jing1; Gu, Jin3; Yuan, Jiajia1; Hua, Dong4; Shen, Lin1
关键词miR-215 Colorectal cancer Relapse 5-FU Adjuvant chemotherapy
刊名MEDICAL ONCOLOGY
2013-06-01
DOI10.1007/s12032-013-0549-0
30期:2
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]II COLON-CANCER ; CELL-CYCLE ; MIR-215 ; RECURRENCE ; EXPRESSION ; RISK
英文摘要

To investigate the role of miR-215 in the relapse following radical surgery of colorectal cancer patients. The clinical data and surgical frozen tumor tissues were retrospectively collected from 125 stage II/III colorectal cancer patients, which contained 60 patients who relapsed and 65 patients who did not relapse within 3 years after surgery. The expression of miR-215 was determined by real-time PCR, and the relationship between miR-215 expression and the relapse was analyzed statistically. miR-215 was downregulated in relapsed patients compared to nonrelapsed patients (P = 0.001). The low expression of miR-215 was significantly correlated with a high probability of 3-year relapse (P = 0.001), which was more obvious in stage III patients P < 0.001). The multivariate analysis showed that miR-215 expression could function as an independent predictive marker for relapse. It seemed that patients with high expressions of miR-215 could benefit from 5-fluorouracilcontaining adjuvant chemotherapy without significant difference, whereas this phenomenon was reverse in patients with low expressions of miR-215. Our study highlighted for the first time that miR-215 could function as a potential predictive marker for relapse following radical surgery of colorectal cancer, and the possible correlation between miR215 and 5-fluorouracil-containing adjuvant chemotherapy would be validated in the future.

语种英语
WOS记录号WOS:000319450400057
引用统计
被引频次:24[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67002
专题北京大学临床肿瘤学院_胃肠肿瘤中心
北京大学临床肿瘤学院_消化肿瘤内科
北京大学临床肿瘤学院_结直肠肿瘤外科
作者单位1.Peking Univ, Canc Hosp & Inst, Dept GI Oncol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
2.Capital Med Univ, Beijing Shijitan Hosp, Beijing, Peoples R China
3.Peking Univ, Canc Hosp & Inst, Dept Colorectal Surg, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
4.Fourth Peoples Hosp Wuxi, Dept Med Oncol, Wuxi, Peoples R China
推荐引用方式
GB/T 7714
Li, Shan,Gao, Jing,Gu, Jin,et al. MicroRNA-215 inhibits relapse of colorectal cancer patients following radical surgery[J]. MEDICAL ONCOLOGY,2013,30(2).
APA Li, Shan,Gao, Jing,Gu, Jin,Yuan, Jiajia,Hua, Dong,&Shen, Lin.(2013).MicroRNA-215 inhibits relapse of colorectal cancer patients following radical surgery.MEDICAL ONCOLOGY,30(2).
MLA Li, Shan,et al."MicroRNA-215 inhibits relapse of colorectal cancer patients following radical surgery".MEDICAL ONCOLOGY 30.2(2013).
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