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学科主题临床医学
Seizure-induced changes in place cell physiology: Relationship to spatial memory
Liu, XZ; Muller, RU; Huang, LT; Kubie, JL; Rotenberg, A; Rivard, B; Cilio, MR; Holmes, GL
关键词water maze epilepsy status epilepticus memory place cell seizures
刊名JOURNAL OF NEUROSCIENCE
2003-12-17
23期:37页:11505-11515
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]COMPLEX-SPIKE CELLS ; CONVULSIVE STATUS EPILEPTICUS ; TEMPORAL-LOBE EPILEPSY ; FREELY-BEHAVING RATS ; NEONATAL SEIZURES ; HIPPOCAMPAL-FORMATION ; EPISODIC MEMORY ; INDUCED DAMAGE ; IMMATURE RATS ; BRAIN-INJURY
英文摘要

Status epilepticus ( SE) is a frequent neurological emergency associated with a significant risk of morbidity in survivors. Impairment of hippocampal-specific memory is a common and serious deficit occurring in many of the survivors. However, the pathophysiological basis of cognitive deficits after SE is not clear. To directly address the cellular concomitants of spatial memory impairment, we recorded the activity of place cells from CA1 in freely moving rats subjected to SE during early development and compared this activity to that in control rats. Place cells discharge rapidly only when the rat′s head is in a cell-specific part of the environment called the "firing field." This firing field remains stable over time. Normal place cell function seems to be essential for stable spatial memory for the environment. We, therefore, compared place cell firing patterns with visual - spatial memory in the water maze in SE and control rats. Compared with controls, place cells from the SE rats were less precise and less stable. Concordantly, the water maze performance was also impaired. There was a close relationship between precision and stability of place cells and water maze performance. In contrast, a single, acute, chemically induced seizure produced cessation of place cell activity and spatial memory impairment in water maze performance that reversed within 24 hr. These results strongly bolster the idea that there is a relationship between abnormal place cells and spatial memory. Our findings also suggest that the defects in place cell and spatial memory after SE and acute chemically induced seizures result from different processes.

语种英语
WOS记录号WOS:000187397400002
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被引频次:74[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67004
专题北京大学第二临床医学院_神经内科
作者单位1.Dartmouth Coll Sch Med, Div Neurol, Ctr Neurosci, Lebanon, NH 03756 USA
2.Harvard Univ, Childrens Hosp Boston, Sch Med, Boston, MA 02115 USA
3.Peking Univ, Hlth Sci Ctr, Dept Neurol, Beijing 100044, Peoples R China
4.SUNY Brooklyn, Dept Physiol & Pharmacol, Brooklyn, NY 11203 USA
5.Univ Bristol, Dept Anat, MRC, Ctr Synapt Plast, Bristol B58 1TD, Avon, England
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GB/T 7714
Liu, XZ,Muller, RU,Huang, LT,et al. Seizure-induced changes in place cell physiology: Relationship to spatial memory[J]. JOURNAL OF NEUROSCIENCE,2003,23(37):11505-11515.
APA Liu, XZ.,Muller, RU.,Huang, LT.,Kubie, JL.,Rotenberg, A.,...&Holmes, GL.(2003).Seizure-induced changes in place cell physiology: Relationship to spatial memory.JOURNAL OF NEUROSCIENCE,23(37),11505-11515.
MLA Liu, XZ,et al."Seizure-induced changes in place cell physiology: Relationship to spatial memory".JOURNAL OF NEUROSCIENCE 23.37(2003):11505-11515.
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