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学科主题: 临床医学
题名:
Thymocyte selection-associated high mobility group box gene (TOX) is aberrantly over-expressed in mycosis fungoides and correlates with poor prognosis
作者: Huang, Yuanshen1,2,3,4; Litvinov, Ivan V.5; Wang, Yang6; Su, Ming-Wan1,2,3; Tu, Ping6; Jiang, Xiaoyan4; Kupper, Thomas S.7; Dutz, Jan P.3,8; Sasseville, Denis5; Zhou, Youwen1,2,3,8
关键词: TOX ; mycosis fungoides ; cutaneous T cell lymphoma ; marker ; prognostic factor
刊名: ONCOTARGET
发表日期: 2014-06-01
卷: 5, 期:12, 页:4418-4425
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Cell Biology
研究领域[WOS]: Oncology ; Cell Biology
关键词[WOS]: T-CELL LYMPHOMA ; SEZARY-SYNDROME ; MARKERS ; BCL7A
英文摘要:

Mycosis fungoides (MF) often mimics the common chronic inflammatory skin diseases and is difficult to be diagnosed with certainty, partly because of the lack of well-characterized molecular markers. Previously, we discovered that TOX, a key T cell development regulator, was aberrantly over-expressed in early stage MF. In the current multi-center study involving two independent patient cohorts, we determined the prevalence of TOX over-expression in the full spectrum of MF skin biopsies, and tested if TOX expression levels correlated with long term clinical outcomes. We examined TOX expression levels in 113 MF biopsies. We found that the MF biopsies expressed higher TOX mRNA than the controls in both cohorts (17.9 fold in cohort 1, P = 0.002; 5.8 fold in cohort 2, P < 0.0001). In addition, thicker skin lesions such as plaques and tumors expressed even higher TOX levels than thinner patches. Further, TOX over-expression differentiated MF from the controls (area under the curve [AUC]= 0.87, P < 0.0001). Finally, high TOX mRNA levels correlated with increased risks of disease progression (P = 0.003) and disease-specific mortality (P = 0.008). In conclusion, TOX may be a useful marker for improving MF diagnosis and prognostication.

语种: 英语
所属项目编号: 81072233 ; 81201228
项目资助者: Canadian Institutes of Health Research ; Canadian Dermatology Foundation ; Fonds de la recherche en sante du Quebec (FRSQ) ; National Natural Science Foundation of China
WOS记录号: WOS:000339055200037
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67009
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.McGill Univ, Ctr Hlth, Div Dermatol, Montreal, PQ, Canada
2.Vancouver Coastal Hlth Res Inst, Mol Med Lab, Vancouver, BC, Canada
3.Vancouver Coastal Hlth Res Inst, Chieng Genom Ctr, Vancouver, BC, Canada
4.British Columbia Canc Agcy, Terry Fox Lab, Vancouver, BC V5Z 1L3, Canada
5.Univ British Columbia, Dept Dermatol & Skin Sci, Vancouver, BC V5Z 1M9, Canada
6.Peking Univ, Hosp 1, Dept Dermatol & Venereol, Beijing 100871, Peoples R China
7.Harvard Univ, Brigham & Womens Hosp, Dept Dermatol, Harvard Skin Dis Res Ctr, Boston, MA 02115 USA
8.British Columbia Canc Agcy, Dermatol Oncol Program, Vancouver, BC V5Z 4E6, Canada

Recommended Citation:
Huang, Yuanshen,Litvinov, Ivan V.,Wang, Yang,et al. Thymocyte selection-associated high mobility group box gene (TOX) is aberrantly over-expressed in mycosis fungoides and correlates with poor prognosis[J]. ONCOTARGET,2014,5(12):4418-4425.
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