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学科主题: 口腔医学
题名:
High MMP-21 expression in metastatic lymph nodes predicts unfavorable overall survival for oral squamous cell carcinoma patients with lymphatic metastasis
作者: Pu, Yinfei1; Wang, Lin1; Wu, Huanhuan1; Feng, Zhien1; Wang, Yixiang2; Guo, Chuanbin1
关键词: oral cancer ; squamous cell carcinoma ; metastasis ; lymph node ; MMP-21
刊名: ONCOLOGY REPORTS
发表日期: 2014-06-01
DOI: 10.3892/or.2014.3124
卷: 31, 期:6, 页:2644-2650
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: MATRIX METALLOPROTEINASE-21 ; CANCER ; LYMPHANGIOGENESIS ; MICROENVIRONMENT ; MECHANISMS ; GENE
英文摘要:

The aim of the present study was to examine the clinical significance of lymph node metastatic (LNM) foci in predicting the overall survival of oral squamous cell carcinoma (OSCC) patients with LNM. MMP-21 was screened based on the LNM animal model of OSCC. Then four proteins, matrix metalloproteinase (MMP)-2, MMP-21, vascular endothelial growth factor (VEGF)-C and VEGF receptor (VEGFR)-3 were examined by immunohistochemistry in 63 OSCC specimens, including the primary tumors (PTs) and the corresponding LNM foci. The expression levels between the PTs and LNM foci were compared by Wilcoxon paired test. Relationships between expression of the four proteins and patient overall survival were assessed by Kaplan-Meier based on the median of the labeling index. The Cox proportional hazards model was used to assess the relative hazard factors. MMP-21 and VEGF-C expression levels were higher in the LNM foci than levels in the PTs. Results showed that MMP-2 and VEGF-C expression levels in the PTs and MMP-2, MMP-21 and VEGF-C expression in the LNM foci correlated with the overall survival of the OSCC patients with lymphatic metastasis. MMP-21 expression level in the LNM foci was the most reliable predictor among all the tested factors. These results suggest that high MMP-21 expression in LNM foci can be used to predict survival in OSCC patients with LNM. Characteristics of LNM foci may be more reliable than PT characteristics in predicting the overall Survival of OSCC patients with lymphatic metastasis.

语种: 英语
所属项目编号: 81341062
项目资助者: Natural Science Foundation of China
WOS记录号: WOS:000336637500022
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67010
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: 1.Peking Univ Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
2.Peking Univ Sch & Hosp Stomatol, Cent Lab, Beijing 100081, Peoples R China

Recommended Citation:
Pu, Yinfei,Wang, Lin,Wu, Huanhuan,et al. High MMP-21 expression in metastatic lymph nodes predicts unfavorable overall survival for oral squamous cell carcinoma patients with lymphatic metastasis[J]. ONCOLOGY REPORTS,2014,31(6):2644-2650.
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