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学科主题: 口腔医学
题名:
A subset of IL-17(+) mesenchymal stem cells possesses anti-Candida albicans effect
作者: Yang, Ruili1,2; Liu, Yi2; Kelk, Peyman2; Qu, Cunye2; Akiyama, Kentaro2; Chen, Chider2; Atsuta, Ikiru2; Chen, WanJun3; Zhou, Yanheng1; Shi, Songtao2
关键词: stem cell biology ; development ; immunity ; molecular pathogenesis
刊名: CELL RESEARCH
发表日期: 2013
DOI: 10.1038/cr.2012.179
卷: 23, 期:1, 页:107-121
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology
研究领域[WOS]: Cell Biology
关键词[WOS]: INTERLEUKIN-17 FAMILY-MEMBERS ; VERSUS-HOST-DISEASE ; REGULATORY T-CELLS ; STROMAL CELLS ; IMMUNOSUPPRESSIVE PROPERTIES ; RESPONSES ; T(H)17 ; BETA ; DIFFERENTIATION ; MICE
英文摘要:

Bone marrow mesenchymal stem cells (MSCs) comprise a heterogeneous population of postnatal progenitor cells with profound immunomodulatory properties, such as upregulation of Foxp3(+) regulatory T cells (Tregs) and downregulation of Th17 cells. However, it is unknown whether different MSC subpopulations possess the same range of immunomodulatory function. Here, we show that a subset of single colony-derived MSCs producing IL-17 is different from bulk MSC population in that it cannot upregulate Tregs, downregulate Th17 cells, or ameliorate disease phenotypes in a colitis mouse model. Mechanistically, we reveal that IL-17, produced by these MSCs, activates the NF kappa B pathway to downregulate TGF-beta production in MSCs, resulting in abolishment of MSC-based immunomodulation. Furthermore, we show that NF kappa B is able to directly bind to TGF-beta promoter region to regulate TGF-beta expression in MSCs. Moreover, these IL-17(+) MSCs possess anti-Candida albicans growth effects in vitro and therapeutic effect in C. albicans-infected mice. In summary, this study shows that MSCs contain an IL-17(+) subset capable of inhibiting C. albicans growth, but attenuating MSC-based immunosuppression via NF kappa B-mediated downregulation of TGF-beta.

语种: 英语
所属项目编号: R01DE017449 ; R01 DE019932 ; R01 DE019413 ; 2010DFB32980
项目资助者: National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH), Department of Health and Human Services ; Ministry of Science and Technology of China ; NIDCR, NIH
WOS记录号: WOS:000313194700014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67011
Appears in Collections:北京大学口腔医学院_牙周科_期刊论文

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作者单位: 1.Peking Univ, Sch & Hosp Stomatol, Dept Orthodont, Beijing 100081, Peoples R China
2.Univ So Calif, Ostrow Sch Dent, Ctr Craniofacial Mol Biol, Los Angeles, CA 90033 USA
3.Natl Inst Dent & Craniofacial Res, NIH, Bethesda, MD 20892 USA

Recommended Citation:
Yang, Ruili,Liu, Yi,Kelk, Peyman,et al. A subset of IL-17(+) mesenchymal stem cells possesses anti-Candida albicans effect[J]. CELL RESEARCH,2013,23(1):107-121.
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