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Clinical significance of matrix metalloproteinase-9 expression in esophageal squamous cell carcinoma
Gu, Zhen-Dong2; Chen, Ke-Neng2; Li, Ming3; Gu, Jin3; Li, Ji-You1
关键词Matrix metalloproteinase-9 Esophageal squamous cell carcinoma Immunohistochemistry Clinicopathological parameters Biomarker
刊名WORLD JOURNAL OF GASTROENTEROLOGY
2005-02-14
11期:6页:871-874
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
英文摘要

AIM: To evaluate the expression of matrix metalloproteinase-9 (MMP-9) and its clinical significance in esophageal squamous cell carcinoma (ESCC).

METHODS: The expression of MMP-9 in 208 cases of ESCC was detected by immunohistochemistry (IHC) and its clinical significance in ESCC especially the relationship with the clinicopathological parameters was analyzed.

RESULTS: The percentage of positive cases for MMP-9 detected by IHC was 49.0%. MMP-9 was mainly expressed in the cytoplasm of cancer cells especially in the invasive front. Only weak expression was detected in the stromal cells and no expression in non-cancerous mucosa. The expression of MMP-9 was positively correlated with poorer differentiation (P = 0.001<0.01), existence of vessel permeation (P = 0.027<0.05) and lymph node metastasis (P = 0.027<0.05).

CONCLUSION: The expression of MMP-9 correlates with the cancer cell differentiation, vessel permeation and lymph node metastasis. It may be a novel biomarker for the diagnosis and treatment of ESCC. (C) 2005 The WJG Press and Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000208100300019
项目编号H020920030390
资助机构Beijing Municipal Science and Technology Commission
引用统计
被引频次:27[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67020
专题北京大学临床肿瘤学院_病理科
北京大学临床肿瘤学院_胸部肿瘤外一科
北京大学临床肿瘤学院_结直肠肿瘤外科
作者单位1.Peking Univ Sch Oncol, Dept Pathol, Beijing Canc Hosp, Beijing 100036, Peoples R China
2.Peking Univ Sch Oncol, Dept Thorac Surg, Beijing Canc Hosp, Beijing 100036, Peoples R China
3.Peking Univ Sch Oncol, Dept Gen Surg, Beijing Canc Hosp, Beijing 100036, Peoples R China
推荐引用方式
GB/T 7714
Gu, Zhen-Dong,Chen, Ke-Neng,Li, Ming,et al. Clinical significance of matrix metalloproteinase-9 expression in esophageal squamous cell carcinoma[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2005,11(6):871-874.
APA Gu, Zhen-Dong,Chen, Ke-Neng,Li, Ming,Gu, Jin,&Li, Ji-You.(2005).Clinical significance of matrix metalloproteinase-9 expression in esophageal squamous cell carcinoma.WORLD JOURNAL OF GASTROENTEROLOGY,11(6),871-874.
MLA Gu, Zhen-Dong,et al."Clinical significance of matrix metalloproteinase-9 expression in esophageal squamous cell carcinoma".WORLD JOURNAL OF GASTROENTEROLOGY 11.6(2005):871-874.
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