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学科主题: 临床医学
题名:
Clinical significance of matrix metalloproteinase-9 expression in esophageal squamous cell carcinoma
作者: Gu, Zhen-Dong2; Chen, Ke-Neng2; Li, Ming3; Gu, Jin3; Li, Ji-You1
关键词: Matrix metalloproteinase-9 ; Esophageal squamous cell carcinoma ; Immunohistochemistry ; Clinicopathological parameters ; Biomarker
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2005-02-14
卷: 11, 期:6, 页:871-874
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
英文摘要:

AIM: To evaluate the expression of matrix metalloproteinase-9 (MMP-9) and its clinical significance in esophageal squamous cell carcinoma (ESCC).

METHODS: The expression of MMP-9 in 208 cases of ESCC was detected by immunohistochemistry (IHC) and its clinical significance in ESCC especially the relationship with the clinicopathological parameters was analyzed.

RESULTS: The percentage of positive cases for MMP-9 detected by IHC was 49.0%. MMP-9 was mainly expressed in the cytoplasm of cancer cells especially in the invasive front. Only weak expression was detected in the stromal cells and no expression in non-cancerous mucosa. The expression of MMP-9 was positively correlated with poorer differentiation (P = 0.001<0.01), existence of vessel permeation (P = 0.027<0.05) and lymph node metastasis (P = 0.027<0.05).

CONCLUSION: The expression of MMP-9 correlates with the cancer cell differentiation, vessel permeation and lymph node metastasis. It may be a novel biomarker for the diagnosis and treatment of ESCC. (C) 2005 The WJG Press and Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: H020920030390
项目资助者: Beijing Municipal Science and Technology Commission
WOS记录号: WOS:000208100300019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67020
Appears in Collections:北京大学临床肿瘤学院_病理科_期刊论文

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作者单位: 1.Peking Univ Sch Oncol, Dept Pathol, Beijing Canc Hosp, Beijing 100036, Peoples R China
2.Peking Univ Sch Oncol, Dept Thorac Surg, Beijing Canc Hosp, Beijing 100036, Peoples R China
3.Peking Univ Sch Oncol, Dept Gen Surg, Beijing Canc Hosp, Beijing 100036, Peoples R China

Recommended Citation:
Gu, Zhen-Dong,Chen, Ke-Neng,Li, Ming,et al. Clinical significance of matrix metalloproteinase-9 expression in esophageal squamous cell carcinoma[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2005,11(6):871-874.
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