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Studies on the metabolism of 4-methylpiperazine-1-carbodithioc acid 3-cyano-3,3-diphenylpropyl ester hydrochloride in rat bile by high-performance liquid chromatography/electrospray ionization tandem mass spectrometry
Jiang, Xiaomei; Kong, Detao; Han, Fangbin; Ling, Xiaomei; Liu, Xiaoyan; Li, Runtao; Cui, Jingrong
刊名RAPID COMMUNICATIONS IN MASS SPECTROMETRY
2007
DOI10.1002/rcm.3001
21期:10页:1599-1605
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Analytical ; Spectroscopy
研究领域[WOS]Chemistry ; Spectroscopy
关键词[WOS]STRONG ANALGESIC ACTIVITY ; FRAGMENTATION PATTERNS ; PHYTOALEXIN BRASSININ ; RAFT POLYMERIZATION ; BLACKLEG FUNGUS ; DERIVATIVES ; DIBROMIDES ; COMPLEXES
英文摘要

4-Methylpiperazine-1-carbodithioc acid 3-cyano-3,3-diphenylpropyl ester hydrochloride (TM208) is a newly synthesized compound which has shown excellent in vivo and in vitro anticancer activity and low toxicity. In the present study, the major metabolites of TM208 in rat bile were studied by high-performance liquid chromatography/tandem mass spectrometry with an electrospray ionization (ESI) interface. It was demonstrated that TM208 was extensively metabolized in rat bile and nine metabolites (M1-M9) were definitely or tentatively identified: (2-aminoethyl)dithiocarbamic acid 3-cyano-3,3-diphenylpropyl ester (Ml), (2-methylaminoethyl)dithiocarbamic acid 3-cyano-3,3-diphenylpropyl ester (M2), 4-[(4-methylpiperazin-1-yl)thioxomethanesulfinyl]-2,2-diphenylbutyronitrile (M3), 4-methylpiperazine-1-carbodithioic acid 3-cyano-3-(4-hydroxyphenyl)-3-phenylpropyl ester(M4), the sulfine of (4-methylpiperazine-1-carbodithioc acid 3-cyano-3,3-diphenylpropyl ester) (M5), 4-methylpiperazine-1-carbothioic acid S-(3-cyano-3,3-diphenylpropyl) ester NO, piperazine-1-carbodithioic acid 3-cyano-3,3-diphenylpropyl ester (M7), 4-hydroxymethylpiperazine-1-carbothioic acid S-(3-cyano-3,3-diphenylpropyl) ester (M8) and the sulfine of [4-methylpiperazine-l-carbodithioic acid 3-cyano-3-(4-hydroxyphenyl)-3-phenylpropyl ester] (M9). Copyright (C) 2007 John Wiley & Sons, Ltd.

语种英语
WOS记录号WOS:000246763500007
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67022
专题北京大学药学院_化学生物学系
作者单位1.Peking Univ, Dept Pharmaceut Anal, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
2.Peking Univ, State Key Lab Nat & Biometr Drugs, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Jiang, Xiaomei,Kong, Detao,Han, Fangbin,et al. Studies on the metabolism of 4-methylpiperazine-1-carbodithioc acid 3-cyano-3,3-diphenylpropyl ester hydrochloride in rat bile by high-performance liquid chromatography/electrospray ionization tandem mass spectrometry[J]. RAPID COMMUNICATIONS IN MASS SPECTROMETRY,2007,21(10):1599-1605.
APA Jiang, Xiaomei.,Kong, Detao.,Han, Fangbin.,Ling, Xiaomei.,Liu, Xiaoyan.,...&Cui, Jingrong.(2007).Studies on the metabolism of 4-methylpiperazine-1-carbodithioc acid 3-cyano-3,3-diphenylpropyl ester hydrochloride in rat bile by high-performance liquid chromatography/electrospray ionization tandem mass spectrometry.RAPID COMMUNICATIONS IN MASS SPECTROMETRY,21(10),1599-1605.
MLA Jiang, Xiaomei,et al."Studies on the metabolism of 4-methylpiperazine-1-carbodithioc acid 3-cyano-3,3-diphenylpropyl ester hydrochloride in rat bile by high-performance liquid chromatography/electrospray ionization tandem mass spectrometry".RAPID COMMUNICATIONS IN MASS SPECTROMETRY 21.10(2007):1599-1605.
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