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A convenient and practical prepapation of acetylphenyl boronic acids
Chao, JP; Wang, W; Wu, WQ; Luo, XD; Ling, YZ
关键词p-m-, o-acetylphenylboronic acid grignard reaction Mg- and Li-halogen exhange
刊名CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
2004-11-01
20期:6页:734-737
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]CROSS-COUPLING REACTIONS
英文摘要

A practical and scalable synthesis route of acetylphenylboronic acids is described. Bromoacetophenones (compounds 3a, 3b) were ketalized with ethylene glycol and triethyl orthoformate to give bromo ketals(compounds 4a-4c) in 60-80% yields. Compounds 4a-4b were treated with a Grignard reagent and then exchanged with borate to give p- and m-acetylphenyl boronic acids(compounds 5a and 5b) in 80% and 56% yields, respectively. The o-form(compound 5c) was obtained in 61% yield via the BuLi method.

语种英语
WOS记录号WOS:000225813000014
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67023
专题北京大学药学院
作者单位1.Natl Inst Pharmaceut Res & Dev, Beijing 100226, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Chao, JP,Wang, W,Wu, WQ,et al. A convenient and practical prepapation of acetylphenyl boronic acids[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2004,20(6):734-737.
APA Chao, JP,Wang, W,Wu, WQ,Luo, XD,&Ling, YZ.(2004).A convenient and practical prepapation of acetylphenyl boronic acids.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,20(6),734-737.
MLA Chao, JP,et al."A convenient and practical prepapation of acetylphenyl boronic acids".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 20.6(2004):734-737.
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