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学科主题: 药学
题名:
A convenient and practical prepapation of acetylphenyl boronic acids
作者: Chao, JP; Wang, W; Wu, WQ; Luo, XD; Ling, YZ
关键词: p-m-, o-acetylphenylboronic acid ; grignard reaction ; Mg- and Li-halogen exhange
刊名: CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
发表日期: 2004-11-01
卷: 20, 期:6, 页:734-737
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: CROSS-COUPLING REACTIONS
英文摘要:

A practical and scalable synthesis route of acetylphenylboronic acids is described. Bromoacetophenones (compounds 3a, 3b) were ketalized with ethylene glycol and triethyl orthoformate to give bromo ketals(compounds 4a-4c) in 60-80% yields. Compounds 4a-4b were treated with a Grignard reagent and then exchanged with borate to give p- and m-acetylphenyl boronic acids(compounds 5a and 5b) in 80% and 56% yields, respectively. The o-form(compound 5c) was obtained in 61% yield via the BuLi method.

语种: 英语
WOS记录号: WOS:000225813000014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67023
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Natl Inst Pharmaceut Res & Dev, Beijing 100226, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China

Recommended Citation:
Chao, JP,Wang, W,Wu, WQ,et al. A convenient and practical prepapation of acetylphenyl boronic acids[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2004,20(6):734-737.
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