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学科主题: 口腔医学
题名:
Beneficial Effects and Safety of Corticosteroids Combined with Traditional Chinese Medicine for Pemphigus: A Systematic Review
作者: Zhou, Tingting; Zhou, Peiru; Hua, Hong; Liu, Xiaosong
刊名: EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
发表日期: 2015
DOI: 10.1155/2015/815358
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Integrative & Complementary Medicine
研究领域[WOS]: Integrative & Complementary Medicine
英文摘要:

Objective. To evaluate the beneficial effects and safety of corticosteroids combined with traditional Chinese medicine (TCM) for pemphigus. Methods. Seven electronic databases were searched to identify any potential randomized controlled trials (RCTs) or clinical controlled trials (CCTs) that compared corticosteroids with and without TCM for the treatment of pemphigus, published in any language. Remission of the mucocutaneous lesions, therapeutic duration, dosage of corticosteroids, and specific antibody titers were employed as the main outcome measures. The methodological quality of the included studies was assessed using the Cochrane Handbook for Systematic Review of Interventions and Rev Man 5.1.0 software. Results. Four RCTs with a total of 199 patients were included in the present review. Management with corticosteroids combined with TCM seemed to benefit pemphigus patients in terms of healing of lesions, prevention of complications and relapse, and reduced interferon-gamma (IFN-gamma) level. The trials were not of high methodological quality. No study mentioned allocation concealment and blinding. Only one trial reported adverse events, and it indicated that the safety of corticosteroids combined with TCM was uncertain. Conclusion. There is some, albeit weak, evidence to show that combined treatment with corticosteroids with TCM could be of benefit for some patients with pemphigus. The efficacy and safety of this combined treatment should be evaluated further in better designed, fully powered, and confirmatory RCTs.

语种: 英语
所属项目编号: 7142168
项目资助者: National Key Clinic Program ; Beijing Natural Science Foundation
WOS记录号: WOS:000352460100001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67029
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: Peking Univ, Sch & Hosp Stomatol, Dept Oral Med, Beijing 100081, Peoples R China

Recommended Citation:
Zhou, Tingting,Zhou, Peiru,Hua, Hong,et al. Beneficial Effects and Safety of Corticosteroids Combined with Traditional Chinese Medicine for Pemphigus: A Systematic Review[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2015.
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