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学科主题: 临床医学
题名:
Mannose-binding lectin and vulvovaginal candidiasis
作者: Liu, F; Liao, QP; Liu, ZH
关键词: mannose-binding lectin ; vulvovaginal candidiasis ; cervicovaginal lavage ; polymorphism
刊名: INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
发表日期: 2006
DOI: 10.1016/j.ijgo.2005.08.024
卷: 92, 期:1, 页:43-47
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Obstetrics & Gynecology
研究领域[WOS]: Obstetrics & Gynecology
关键词[WOS]: HOST-DEFENSE ; PROTEIN GENE ; PHAGOCYTOSIS ; POPULATIONS ; MUTATIONS ; SYSTEM
英文摘要:

Objective: To investigate the effect of mannose-binding lectin (MBL) gene potymorphism on the immune system and the significance of vaginal MBL concentration in the pathogenesis of vulvovaginal candidiasis (VVC) and recurrent VVC (rVVC). Patients and methods: Mannose-binding lectin concentrations in CVL samples from 111 women were collected between August 2004 and November 2004, 51 with VVC, 6 with rVVC patients, and 54 healthy women. CVL MBL concentrations were determined by enzyme-linked immunosorbent assay, and MBL gene potymorphism was analyzed by polymerase chain reaction and the restriction fragment length polymorphism method. Results: Cervicovaginal lavage MBL concentration (17.80 ng/mL) and gene mutation frequency (33.33%) were both significantly higher in women with VVC (P < 0.01) than in controls (odds ratio [OR], 2.93; 95% confidence interval [CI], 1.14-7.57; P < 0.05). On the other hand, MBL concentration was tower in women with rVVC (0.30 ng/mL) than in controls (1.28 ng/mL) (P < 0.05), although MBL gene mutation frequency (83.33%) was significantly higher in women with rVVC than in controls (OR, 26.87; 95% Cl, 2.76-261.65; P < 0.01). Conclusions: The presence of VVC can increase vaginal MBL level, which may be an immune response against Candida albicans infection; in women with rVVC, the low level of MBL in the vagina caused by mutation in the MBL gene may play a rote in the recurrence of the infection. (c) 2005 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000234904500009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67031
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: Peking Univ, Hosp 1, Dept Obstet & Gynecol, Beijing, Peoples R China

Recommended Citation:
Liu, F,Liao, QP,Liu, ZH. Mannose-binding lectin and vulvovaginal candidiasis[J]. INTERNATIONAL JOURNAL OF GYNECOLOGY &amp; OBSTETRICS,2006,92(1):43-47.
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