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学科主题: 基础医学
题名:
Hemokinin-1 Activates the MAPK Pathway and Enhances B Cell Proliferation and Antibody Production
作者: Wang, Wei1; Li, Qian1; Zhang, Jun1; Wu, Hounan2; Yin, Yanhui1; Ge, Qing1; Zhang, Yu1
刊名: JOURNAL OF IMMUNOLOGY
发表日期: 2010-04-01
DOI: 10.4049/jimmunol.0901278
卷: 184, 期:7, 页:3590-3597
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: P-LIKE FUNCTION ; SUBSTANCE-P ; PHARMACOLOGICAL PROFILE ; MAMMALIAN TACHYKININ ; GENE-EXPRESSION ; DENDRITIC CELLS ; PLASMA-CELLS ; IN-VIVO ; RECEPTOR ; DIFFERENTIATION
英文摘要:

Hemokinin I (HK-1) is a substance P-like tachykinin peptide predominantly expressed in non-neuronal tissues. In addition to a prominent function in lymphoid development, recent studies indicate a potential role for HK-1 in immunoregulation. The current study was focused on its action on mature B cells. Despite the negligible effect on its own, HK-1 exhibited a profound influence on B cell activation elicited by several classical signals, including LPS stimulation, BCR cross-linking, and CD40 ligation. Cells therefore showed enhanced proliferation, survival, and CD80/86 expression, and produced more IgM with a higher frequency of Ab-forming cells. Biochemical analysis revealed that HK-1 alone was sufficient to induce the activation of MAPKs and the expression of Blimp-1 and Xbp-1 in B cells. Nevertheless, costimulation with a known B cell activator resulted in much enhanced phosphorylation of MAPKs and transcriptional activation of Blimp-1 and Xbp-1. Overall, these data support that HK-1 provides an important costimulatory signal for B cell activation, possibly through synergistic activation of the MAPK pathway and induction of transcription factors critical for plasmacytic differentiation. The Journal of Immunology, 2010, 184: 3590-3597.

语种: 英语
所属项目编号: 30830091 ; 30525044 ; 2006CB504300 ; 2006CB910101 ; 2010CB945301 ; B07001
项目资助者: National Natural Sciences Foundation ; Natural Basic Research Program of China
WOS记录号: WOS:000275927600037
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67043
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100871, Peoples R China
2.Peking Univ, Ctr Hlth & Med Anal, Beijing 100871, Peoples R China

Recommended Citation:
Wang, Wei,Li, Qian,Zhang, Jun,et al. Hemokinin-1 Activates the MAPK Pathway and Enhances B Cell Proliferation and Antibody Production[J]. JOURNAL OF IMMUNOLOGY,2010,184(7):3590-3597.
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