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学科主题基础医学
Hemokinin-1 Activates the MAPK Pathway and Enhances B Cell Proliferation and Antibody Production
Wang, Wei1; Li, Qian1; Zhang, Jun1; Wu, Hounan2; Yin, Yanhui1; Ge, Qing1; Zhang, Yu1
刊名JOURNAL OF IMMUNOLOGY
2010-04-01
DOI10.4049/jimmunol.0901278
184期:7页:3590-3597
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]P-LIKE FUNCTION ; SUBSTANCE-P ; PHARMACOLOGICAL PROFILE ; MAMMALIAN TACHYKININ ; GENE-EXPRESSION ; DENDRITIC CELLS ; PLASMA-CELLS ; IN-VIVO ; RECEPTOR ; DIFFERENTIATION
英文摘要

Hemokinin I (HK-1) is a substance P-like tachykinin peptide predominantly expressed in non-neuronal tissues. In addition to a prominent function in lymphoid development, recent studies indicate a potential role for HK-1 in immunoregulation. The current study was focused on its action on mature B cells. Despite the negligible effect on its own, HK-1 exhibited a profound influence on B cell activation elicited by several classical signals, including LPS stimulation, BCR cross-linking, and CD40 ligation. Cells therefore showed enhanced proliferation, survival, and CD80/86 expression, and produced more IgM with a higher frequency of Ab-forming cells. Biochemical analysis revealed that HK-1 alone was sufficient to induce the activation of MAPKs and the expression of Blimp-1 and Xbp-1 in B cells. Nevertheless, costimulation with a known B cell activator resulted in much enhanced phosphorylation of MAPKs and transcriptional activation of Blimp-1 and Xbp-1. Overall, these data support that HK-1 provides an important costimulatory signal for B cell activation, possibly through synergistic activation of the MAPK pathway and induction of transcription factors critical for plasmacytic differentiation. The Journal of Immunology, 2010, 184: 3590-3597.

语种英语
WOS记录号WOS:000275927600037
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被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
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条目标识符http://ir.bjmu.edu.cn/handle/400002259/67043
专题北京大学基础医学院_免疫学系
北京大学基础医学院
北京大学中国卫生发展研究中心
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100871, Peoples R China
2.Peking Univ, Ctr Hlth & Med Anal, Beijing 100871, Peoples R China
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Wang, Wei,Li, Qian,Zhang, Jun,et al. Hemokinin-1 Activates the MAPK Pathway and Enhances B Cell Proliferation and Antibody Production[J]. JOURNAL OF IMMUNOLOGY,2010,184(7):3590-3597.
APA Wang, Wei.,Li, Qian.,Zhang, Jun.,Wu, Hounan.,Yin, Yanhui.,...&Zhang, Yu.(2010).Hemokinin-1 Activates the MAPK Pathway and Enhances B Cell Proliferation and Antibody Production.JOURNAL OF IMMUNOLOGY,184(7),3590-3597.
MLA Wang, Wei,et al."Hemokinin-1 Activates the MAPK Pathway and Enhances B Cell Proliferation and Antibody Production".JOURNAL OF IMMUNOLOGY 184.7(2010):3590-3597.
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