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学科主题: 临床医学
题名:
Effects of the novel 6% hydroxyethyl starch 130/0.4 on renal function of recipients in living-related kidney transplantation
作者: Wu Yan1; Wu An-shi1; Wang Jun2; Tian Ming3; Jia Xin-yuan4; Rui Yan1; Yue Yun1
关键词: hydroxyethyl starch ; renal function ; living-related kidney transplantation
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2010-11-05
DOI: 10.3760/cma.j.issn.0366-6999.2010.21.023
卷: 123, 期:21, 页:3079-3083
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: MICROVASCULAR PERMEABILITY ; SEVERE SEPSIS ; SURGERY ; VOLUVEN(R) ; SURVIVAL ; RESUSCITATION ; SUBSTITUTION ; HES-200/0.5 ; HES-130/0.4 ; DYSFUNCTION
英文摘要:

Background The optimal colloid for use during kidney transplantation is not clear. Patients undergoing living-related kidney transplantation (LRKT) were used to compare the protective effects of 6% hydroxyethyl starch 130/0.4 (HES 130/0.4) and 4% succinylated gelatine, as donor kidney procurement, ischemia time and surgical conditions are comparable. Stroke volume variation (SVV) was used to monitor intravascular volume to avoid renal allograft hypoperfusion.

Methods Eighty patients undergoing LRKT were divided into two groups: group H received 6% HES 130/0.4 and group G received 4% succinylated gelatine. All donors and recipients received 15-25 ml/kg of the relevant colloid during surgery. Arterial blood pressure (ABP), heart rate (HR), central venous pressure (CVP), SW and cardiac index (Cl), electrocardiography (ECG) and SpO(2) were monitored continuously. SVV was kept between 6%-13% and mean arterial pressure at 100-130 mmHg. Samples of venous blood and urine were obtained 30 minutes after unclamping and on the mornings of post-operative days (POD) 1-4 to measure serum and urine beta 2-microglobulin, urine alpha 1-microglobulin, microalbumin and N-acetyl-beta-D-glucosaminidase. Blood urea nitrogen (BUN) and creatine were determined pre-operation (t(0)), 3 hours after surgery (t(1)) and on PODs 1 (t(2)), 2 (t(3)), 4 (t(4)), 7 (t(5)) and 10 (t(6)). Urine output was recorded at t(1), t(2), t(5), t(6).

Results Age, body weight, body surface area (BSA), operation time, urine output and the colloid volume infused were comparable between the groups and hemodynamics were stable during surgery. BUN, serum creatine, serum beta 2-microglobulin and urine beta 2-microglobulin decreased significantly after surgery in both groups relative to the baseline. BUN decreased significantly in group H compared with group G at t(1), t(2) and t(4). Urine microalbumin decreased significantly in group H on POD 4 compared with group G. Urine alpha 1-microglobulin was not significantly different between the two groups.

Conclusion Both colloids can be safely used for LRKT, but HES130/0.4 was associated with a more rapid recovery of renal function. Chin Med J 2010;123(21):3079-3083

语种: 英语
WOS记录号: WOS:000284387200023
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67044
Appears in Collections:北京大学第三临床医学院_麻醉科_期刊论文

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作者单位: 1.Capital Med Univ, Beijing Chaoyang Hosp, Dept Anesthesiol, Beijing 100020, Peoples R China
2.Peking Univ, Hosp 3, Dept Anesthesiol, Beijing 100083, Peoples R China
3.Capital Med Univ, Beijing Friendship Hosp, Dept Anesthesiol, Beijing 100050, Peoples R China
4.Capital Med Univ, Beijing Chaoyang Hosp, Basic Med Res Ctr, Beijing 100020, Peoples R China

Recommended Citation:
Wu Yan,Wu An-shi,Wang Jun,et al. Effects of the novel 6% hydroxyethyl starch 130/0.4 on renal function of recipients in living-related kidney transplantation[J]. CHINESE MEDICAL JOURNAL,2010,123(21):3079-3083.
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