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Antinociceptive Efficacy of Verticinone in Murine Models of Inflammatory Pain and Paclitaxel Induced Neuropathic Pain
Xu, Fangzhou1; Xu, Shongzhou2; Wang, Lijun1; Chen, Chuntao3; Zhou, Xueqing1; Lu, Yuzhen1; Zhang, Huihui4
关键词verticinone analgesic formalin inflammatory pain neuropathic pain paclitaxel
刊名BIOLOGICAL & PHARMACEUTICAL BULLETIN
2011-09-01
34期:9页:1377-1382
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]COUGH THERAPEUTIC AGENT ; QUALITY-OF-LIFE ; FORMALIN TEST ; PERIPHERAL NEUROPATHY ; FRITILLARIA-USSURIENSIS ; MECHANICAL ALLODYNIA ; CANCER-PATIENTS ; RATS ; MANAGEMENT ; RECEPTOR
英文摘要

Verticinone, an isosteroidal alkaloid separated from Bulbus Fritillaria (Chinese name "Bei-mu"), was evaluated for its analgesic activities in murine models of inflammatory and neuropathic pain. It was shown that oral administarion of verticinone could significantly inhibit acetic acid-induced writhing response in a dose-dependent way, and the writhing inhibition of 3 mg/kg verticinone was 66.2%, which was approximately higher than that of 200 mg/kg aspirin. In the formalin test, a high dose of (3 mg/kg) verticinone could inhibit the nociceptive response of both phases, but the lower dose (1.5 mg/kg) could only inhibit the second phase response, which suggested that verticinone might exert its analgesic effect through both central and peripheral mechanisms. In addition, in formalin and acetic acid tests, the spontaneous locomotive activities of the mice treated with verticinone were transiently greatly decreased when compared with the vehicle group. In the rat model of paclitaxel induced neuropathic pain, in contrast to the declined analgesic effect of morphine after repeated administration with the same dose, a relatively constant analgesic effect of verticinone was observed. These investigations suggested that verticinone could exert a good antinociceptive effect on inflammatory pain and cancer-related neuropathic pain probably through both peripheral and central mechanisms, and it might be partly involved with some sedation effects. Verticinone is expected to become a potentially novel sedative-analgesic agent without producing tolerance and dependence, but further studies are still urgently needed to elucidate the precise mechanisms and activities of it.

语种英语
WOS记录号WOS:000294388500006
项目编号30901983 ; 451803601000780 ; A2008630
资助机构National Natural Science Foundation of China ; Natural Science Foundation of Guangdong Province ; Medical Scientific Research Foundation of Guangdong Province
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67045
专题北京大学深圳医院_药学部
北京大学基础医学院
作者单位1.Peking Univ, Dept Pharm, Shenzhen Hosp, Shenzhen 518036, Peoples R China
2.Peking Univ, Dept Pediat, Shenzhen Hosp, Shenzhen 518036, Peoples R China
3.Peking Univ, Ctr Informat, Shenzhen Hosp, Shenzhen 518036, Peoples R China
4.Jinan Univ, Dept Pharm, Guangzhou 510632, Guangdong, Peoples R China
推荐引用方式
GB/T 7714
Xu, Fangzhou,Xu, Shongzhou,Wang, Lijun,et al. Antinociceptive Efficacy of Verticinone in Murine Models of Inflammatory Pain and Paclitaxel Induced Neuropathic Pain[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2011,34(9):1377-1382.
APA Xu, Fangzhou.,Xu, Shongzhou.,Wang, Lijun.,Chen, Chuntao.,Zhou, Xueqing.,...&Zhang, Huihui.(2011).Antinociceptive Efficacy of Verticinone in Murine Models of Inflammatory Pain and Paclitaxel Induced Neuropathic Pain.BIOLOGICAL & PHARMACEUTICAL BULLETIN,34(9),1377-1382.
MLA Xu, Fangzhou,et al."Antinociceptive Efficacy of Verticinone in Murine Models of Inflammatory Pain and Paclitaxel Induced Neuropathic Pain".BIOLOGICAL & PHARMACEUTICAL BULLETIN 34.9(2011):1377-1382.
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