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学科主题: 药学
题名:
Antinociceptive Efficacy of Verticinone in Murine Models of Inflammatory Pain and Paclitaxel Induced Neuropathic Pain
作者: Xu, Fangzhou1; Xu, Shongzhou2; Wang, Lijun1; Chen, Chuntao3; Zhou, Xueqing1; Lu, Yuzhen1; Zhang, Huihui4
关键词: verticinone ; analgesic ; formalin ; inflammatory pain ; neuropathic pain ; paclitaxel
刊名: BIOLOGICAL & PHARMACEUTICAL BULLETIN
发表日期: 2011-09-01
卷: 34, 期:9, 页:1377-1382
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: COUGH THERAPEUTIC AGENT ; QUALITY-OF-LIFE ; FORMALIN TEST ; PERIPHERAL NEUROPATHY ; FRITILLARIA-USSURIENSIS ; MECHANICAL ALLODYNIA ; CANCER-PATIENTS ; RATS ; MANAGEMENT ; RECEPTOR
英文摘要:

Verticinone, an isosteroidal alkaloid separated from Bulbus Fritillaria (Chinese name "Bei-mu"), was evaluated for its analgesic activities in murine models of inflammatory and neuropathic pain. It was shown that oral administarion of verticinone could significantly inhibit acetic acid-induced writhing response in a dose-dependent way, and the writhing inhibition of 3 mg/kg verticinone was 66.2%, which was approximately higher than that of 200 mg/kg aspirin. In the formalin test, a high dose of (3 mg/kg) verticinone could inhibit the nociceptive response of both phases, but the lower dose (1.5 mg/kg) could only inhibit the second phase response, which suggested that verticinone might exert its analgesic effect through both central and peripheral mechanisms. In addition, in formalin and acetic acid tests, the spontaneous locomotive activities of the mice treated with verticinone were transiently greatly decreased when compared with the vehicle group. In the rat model of paclitaxel induced neuropathic pain, in contrast to the declined analgesic effect of morphine after repeated administration with the same dose, a relatively constant analgesic effect of verticinone was observed. These investigations suggested that verticinone could exert a good antinociceptive effect on inflammatory pain and cancer-related neuropathic pain probably through both peripheral and central mechanisms, and it might be partly involved with some sedation effects. Verticinone is expected to become a potentially novel sedative-analgesic agent without producing tolerance and dependence, but further studies are still urgently needed to elucidate the precise mechanisms and activities of it.

语种: 英语
所属项目编号: 30901983 ; 451803601000780 ; A2008630
项目资助者: National Natural Science Foundation of China ; Natural Science Foundation of Guangdong Province ; Medical Scientific Research Foundation of Guangdong Province
WOS记录号: WOS:000294388500006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67045
Appears in Collections:北京大学深圳医院_药学部_期刊论文

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作者单位: 1.Peking Univ, Dept Pharm, Shenzhen Hosp, Shenzhen 518036, Peoples R China
2.Peking Univ, Dept Pediat, Shenzhen Hosp, Shenzhen 518036, Peoples R China
3.Peking Univ, Ctr Informat, Shenzhen Hosp, Shenzhen 518036, Peoples R China
4.Jinan Univ, Dept Pharm, Guangzhou 510632, Guangdong, Peoples R China

Recommended Citation:
Xu, Fangzhou,Xu, Shongzhou,Wang, Lijun,et al. Antinociceptive Efficacy of Verticinone in Murine Models of Inflammatory Pain and Paclitaxel Induced Neuropathic Pain[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2011,34(9):1377-1382.
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