IR@PKUHSC  > 北京大学深圳医院  > 药学部
学科主题药学
Antinociceptive Efficacy of Verticinone in Murine Models of Inflammatory Pain and Paclitaxel Induced Neuropathic Pain
Xu, Fangzhou1; Xu, Shongzhou2; Wang, Lijun1; Chen, Chuntao3; Zhou, Xueqing1; Lu, Yuzhen1; Zhang, Huihui4
关键词verticinone analgesic formalin inflammatory pain neuropathic pain paclitaxel
刊名BIOLOGICAL & PHARMACEUTICAL BULLETIN
2011-09-01
34期:9页:1377-1382
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
资助者National Natural Science Foundation of China ; Natural Science Foundation of Guangdong Province ; Medical Scientific Research Foundation of Guangdong Province ; National Natural Science Foundation of China ; Natural Science Foundation of Guangdong Province ; Medical Scientific Research Foundation of Guangdong Province
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]COUGH THERAPEUTIC AGENT ; QUALITY-OF-LIFE ; FORMALIN TEST ; PERIPHERAL NEUROPATHY ; FRITILLARIA-USSURIENSIS ; MECHANICAL ALLODYNIA ; CANCER-PATIENTS ; RATS ; MANAGEMENT ; RECEPTOR
英文摘要

Verticinone, an isosteroidal alkaloid separated from Bulbus Fritillaria (Chinese name "Bei-mu"), was evaluated for its analgesic activities in murine models of inflammatory and neuropathic pain. It was shown that oral administarion of verticinone could significantly inhibit acetic acid-induced writhing response in a dose-dependent way, and the writhing inhibition of 3 mg/kg verticinone was 66.2%, which was approximately higher than that of 200 mg/kg aspirin. In the formalin test, a high dose of (3 mg/kg) verticinone could inhibit the nociceptive response of both phases, but the lower dose (1.5 mg/kg) could only inhibit the second phase response, which suggested that verticinone might exert its analgesic effect through both central and peripheral mechanisms. In addition, in formalin and acetic acid tests, the spontaneous locomotive activities of the mice treated with verticinone were transiently greatly decreased when compared with the vehicle group. In the rat model of paclitaxel induced neuropathic pain, in contrast to the declined analgesic effect of morphine after repeated administration with the same dose, a relatively constant analgesic effect of verticinone was observed. These investigations suggested that verticinone could exert a good antinociceptive effect on inflammatory pain and cancer-related neuropathic pain probably through both peripheral and central mechanisms, and it might be partly involved with some sedation effects. Verticinone is expected to become a potentially novel sedative-analgesic agent without producing tolerance and dependence, but further studies are still urgently needed to elucidate the precise mechanisms and activities of it.

语种英语
所属项目编号30901983 ; 451803601000780 ; A2008630
资助者National Natural Science Foundation of China ; Natural Science Foundation of Guangdong Province ; Medical Scientific Research Foundation of Guangdong Province ; National Natural Science Foundation of China ; Natural Science Foundation of Guangdong Province ; Medical Scientific Research Foundation of Guangdong Province
WOS记录号WOS:000294388500006
Citation statistics
Cited Times:12[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67045
Collection北京大学深圳医院_药学部
作者单位1.Peking Univ, Dept Pharm, Shenzhen Hosp, Shenzhen 518036, Peoples R China
2.Peking Univ, Dept Pediat, Shenzhen Hosp, Shenzhen 518036, Peoples R China
3.Peking Univ, Ctr Informat, Shenzhen Hosp, Shenzhen 518036, Peoples R China
4.Jinan Univ, Dept Pharm, Guangzhou 510632, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Xu, Fangzhou,Xu, Shongzhou,Wang, Lijun,et al. Antinociceptive Efficacy of Verticinone in Murine Models of Inflammatory Pain and Paclitaxel Induced Neuropathic Pain[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2011,34(9):1377-1382.
APA Xu, Fangzhou.,Xu, Shongzhou.,Wang, Lijun.,Chen, Chuntao.,Zhou, Xueqing.,...&Zhang, Huihui.(2011).Antinociceptive Efficacy of Verticinone in Murine Models of Inflammatory Pain and Paclitaxel Induced Neuropathic Pain.BIOLOGICAL & PHARMACEUTICAL BULLETIN,34(9),1377-1382.
MLA Xu, Fangzhou,et al."Antinociceptive Efficacy of Verticinone in Murine Models of Inflammatory Pain and Paclitaxel Induced Neuropathic Pain".BIOLOGICAL & PHARMACEUTICAL BULLETIN 34.9(2011):1377-1382.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
谷歌学术
谷歌学术Similar articles in
[Xu, Fangzhou]'s Articles
[Xu, Shongzhou]'s Articles
[Wang, Lijun]'s Articles
百度学术
百度学术Similar articles in
[Xu, Fangzhou]'s Articles
[Xu, Shongzhou]'s Articles
[Wang, Lijun]'s Articles
必应学术
必应学术Similar articles in
[Xu, Fangzhou]'s Articles
[Xu, Shongzhou]'s Articles
[Wang, Lijun]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.