IR@PKUHSC  > 北京大学口腔医学院
学科主题口腔医学
Ischemic preconditioning reduces transplanted submandibular gland injury
Yang, Ning-Yan3; Shi, Liang4; Zhang, Yan1,2; Ding, Chong5; Cong, Xin1,2; Fu, Feng-Ying1,2; Wu, Li-Ling1,2; Yu, Guang-Yan3
关键词Apoptosis Ischemic preconditioning Reactive oxygen species Submandibular gland Transplantation
刊名JOURNAL OF SURGICAL RESEARCH
2013
DOI10.1016/j.jss.2012.02.066
179期:1页:E265-E273
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Surgery
研究领域[WOS]Surgery
关键词[WOS]REPERFUSION INJURY ; ISCHEMIA/REPERFUSION INJURY ; KERATOCONJUNCTIVITIS SICCA ; LIVER-TRANSPLANTATION ; RAT-LIVER ; CEREBRAL-ISCHEMIA ; HEPATIC ISCHEMIA ; OXIDATIVE DAMAGE ; KAPPA-B ; APOPTOSIS
英文摘要

Background: Ischemic preconditioning (IPC) can reduce ischemia/reperfusion (I/R) injury in multiple organs and species. However, the effect of IPC on transplanted submandibular glands remains unknown. We explored the protection of IPC in transplanted submandibular glands in the rabbit and the underlying mechanism.

Methods: IPC was performed by clamping the lingual artery for 10 min, with 10 min of reperfusion before transplantation. Male rabbits were randomly divided into control, transplantation, and IPC groups (n = 6 each). Saliva secretion, oxidative stress, pro-inflammatory cytokine levels, and apoptosis-related protein levels were determined at 1, 12, and 24 h after reperfusion.

Results: Salivary flow was significantly increased at 12 h and decreased at 24 h in the transplanted glands. IPC treatment prevented the reduced saliva secretion at 24 h after reperfusion (P < 0.01). The mRNA levels of tumor necrosis factor-alpha, interleukin-1 beta, and reactive oxygen species, as well as malondialodehyde (MDA) and myeloperoxidase activity, were significantly increased and superoxide dismutase activity was decreased in the transplanted glands. However, these changes were all attenuated with IPC treatment (all P < 0.05). Also, acinar cell apoptosis and Bax protein expression were decreased and Bcl-2 protein expression was increased in the IPC-treated glands at 1 and 12 h after reperfusion (all P < 0.05).

Conclusions: IPC protects the secretory function of transplanted submandibular gland in the rabbit by reducing the inflammatory response, attenuating oxidative stress, and an antiapoptosis process. (C) 2013 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000312129700033
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67048
专题北京大学口腔医学院
北京大学基础医学院
北京大学口腔医学院_外科
北京大学口腔医学院_中心实验室
作者单位1.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100191, Peoples R China
3.Peking Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100191, Peoples R China
4.Shandong Univ, Qilu Hosp, Dept Oral & Maxillofacial Surg, Jinan, Shandong, Peoples R China
5.Peking Univ, Sch & Hosp Stomatol, Cent Lab, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Yang, Ning-Yan,Shi, Liang,Zhang, Yan,et al. Ischemic preconditioning reduces transplanted submandibular gland injury[J]. JOURNAL OF SURGICAL RESEARCH,2013,179(1):E265-E273.
APA Yang, Ning-Yan.,Shi, Liang.,Zhang, Yan.,Ding, Chong.,Cong, Xin.,...&Yu, Guang-Yan.(2013).Ischemic preconditioning reduces transplanted submandibular gland injury.JOURNAL OF SURGICAL RESEARCH,179(1),E265-E273.
MLA Yang, Ning-Yan,et al."Ischemic preconditioning reduces transplanted submandibular gland injury".JOURNAL OF SURGICAL RESEARCH 179.1(2013):E265-E273.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Yang, Ning-Yan]的文章
[Shi, Liang]的文章
[Zhang, Yan]的文章
百度学术
百度学术中相似的文章
[Yang, Ning-Yan]的文章
[Shi, Liang]的文章
[Zhang, Yan]的文章
必应学术
必应学术中相似的文章
[Yang, Ning-Yan]的文章
[Shi, Liang]的文章
[Zhang, Yan]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。