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学科主题: 口腔医学
题名:
Ischemic preconditioning reduces transplanted submandibular gland injury
作者: Yang, Ning-Yan3; Shi, Liang4; Zhang, Yan1,2; Ding, Chong5; Cong, Xin1,2; Fu, Feng-Ying1,2; Wu, Li-Ling1,2; Yu, Guang-Yan3
关键词: Apoptosis ; Ischemic preconditioning ; Reactive oxygen species ; Submandibular gland ; Transplantation
刊名: JOURNAL OF SURGICAL RESEARCH
发表日期: 2013
DOI: 10.1016/j.jss.2012.02.066
卷: 179, 期:1, 页:E265-E273
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Surgery
研究领域[WOS]: Surgery
关键词[WOS]: REPERFUSION INJURY ; ISCHEMIA/REPERFUSION INJURY ; KERATOCONJUNCTIVITIS SICCA ; LIVER-TRANSPLANTATION ; RAT-LIVER ; CEREBRAL-ISCHEMIA ; HEPATIC ISCHEMIA ; OXIDATIVE DAMAGE ; KAPPA-B ; APOPTOSIS
英文摘要:

Background: Ischemic preconditioning (IPC) can reduce ischemia/reperfusion (I/R) injury in multiple organs and species. However, the effect of IPC on transplanted submandibular glands remains unknown. We explored the protection of IPC in transplanted submandibular glands in the rabbit and the underlying mechanism.

Methods: IPC was performed by clamping the lingual artery for 10 min, with 10 min of reperfusion before transplantation. Male rabbits were randomly divided into control, transplantation, and IPC groups (n = 6 each). Saliva secretion, oxidative stress, pro-inflammatory cytokine levels, and apoptosis-related protein levels were determined at 1, 12, and 24 h after reperfusion.

Results: Salivary flow was significantly increased at 12 h and decreased at 24 h in the transplanted glands. IPC treatment prevented the reduced saliva secretion at 24 h after reperfusion (P < 0.01). The mRNA levels of tumor necrosis factor-alpha, interleukin-1 beta, and reactive oxygen species, as well as malondialodehyde (MDA) and myeloperoxidase activity, were significantly increased and superoxide dismutase activity was decreased in the transplanted glands. However, these changes were all attenuated with IPC treatment (all P < 0.05). Also, acinar cell apoptosis and Bax protein expression were decreased and Bcl-2 protein expression was increased in the IPC-treated glands at 1 and 12 h after reperfusion (all P < 0.05).

Conclusions: IPC protects the secretory function of transplanted submandibular gland in the rabbit by reducing the inflammatory response, attenuating oxidative stress, and an antiapoptosis process. (C) 2013 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 30730102 ; 81070847 ; 2007BAI18B11
项目资助者: National Natural Science Foundation of China ; National Supporting Program for Science and Technology
WOS记录号: WOS:000312129700033
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67048
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: 1.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100191, Peoples R China
3.Peking Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100191, Peoples R China
4.Shandong Univ, Qilu Hosp, Dept Oral & Maxillofacial Surg, Jinan, Shandong, Peoples R China
5.Peking Univ, Sch & Hosp Stomatol, Cent Lab, Beijing 100191, Peoples R China

Recommended Citation:
Yang, Ning-Yan,Shi, Liang,Zhang, Yan,et al. Ischemic preconditioning reduces transplanted submandibular gland injury[J]. JOURNAL OF SURGICAL RESEARCH,2013,179(1):E265-E273.
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