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学科主题: 临床医学
题名:
Incidence and prevention of venous thromboembolism in acutely ill hospitalized elderly Chinese
作者: Li Xiao-ying1; Fan Jin1; Cheng You-qin1; Wang Yan1; Yao Chen2; Zhong Nan-shan3
关键词: venous thromboembolism ; deep venous thrombosis ; pulmonary embolism
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2011-02-05
DOI: 10.3760/cma.j.issn.0366-6999.2011.03.003
卷: 124, 期:3, 页:335-340
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: DEEP-VEIN THROMBOSIS ; FATAL PULMONARY-EMBOLISM ; MEDICAL PATIENTS ; RISK-FACTORS ; PROPHYLAXIS ; PREVALENCE ; PLACEBO
英文摘要:

Background As the third most frequent cardiovascular disease, venous thromboembolism (VTE) remains a major cause of morbidity and mortality in hospitalized patients. The aim of this study was to determine the incidence of VTE and steps for its prevention in acutely ill hospitalized elderly Chinese patients.

Methods A prospective multi-center study was conducted from June 2006 to November 2007. A total of 607 patients from 40 research centers in China were enrolled. Data of the patients′ baseline characteristics, VTE events and prophylaxis/therapy methods were collected.

Results Fifty-nine patients (9.7%) had an objectively confirmed VTE during the 90-day follow-up, of which, 59.3% occurred during the first week and 75% within 14 days. Forty-one patients died (6.6%) during the follow-up, 36.6% died within three weeks. We also found that medical disorders including respiratory failure (16.4%), acute brain infarction (15.6%), acute infectious diseases (14.3%), acute coronary artery syndrome (8.7%) and heart failure (7.6%) play a role in provoking VTE. Only 13.0% of the elderly patients with high risk of VTE used low dose unfractionated heparin, 7.1% used low molecular weight heparin, 5.4% used warfarin, 0.3% used graduated compression stockings and none of them used intermittent pneumatic compression.

Conclusions Our study showed similar results between our study and western countries in the VTE incidence by day 90 in elderly hospitalized patients with acute medical illness. Great caution must be applied in the care of acutely ill elderly hospitalized patients to deal with the complications of VTE. Application of safe and effective prophylaxes against embolism remains a critical challenge. Chin Med J 2011;124(3):335-340

语种: 英语
项目资助者: Pfizer Pharmaceuticals Ltd. (China) ; GlaxoSmithKline Investment Co Ltd. (China)
WOS记录号: WOS:000287992400003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67053
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Beijing Univ, Peoples Hosp, Beijing 100044, Peoples R China
2.Guangzhou Inst Resp Dis, Guangzhou 510120, Guangdong, Peoples R China
3.Chinese Peoples Liberat Army Gen Hosp, Dept Geriatr Cardiol, Beijing 100853, Peoples R China

Recommended Citation:
Li Xiao-ying,Fan Jin,Cheng You-qin,et al. Incidence and prevention of venous thromboembolism in acutely ill hospitalized elderly Chinese[J]. CHINESE MEDICAL JOURNAL,2011,124(3):335-340.
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