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学科主题: 临床医学
题名:
Insertion/deletion polymorphism of the ACE gene is associated with type 2 diabetes
作者: Feng, Y; Niu, TH; Xu, X; Chen, CZ; Li, QF; Qian, RL; Wang, GY; Xu, XP
刊名: DIABETES
发表日期: 2002-06-01
卷: 51, 期:6, 页:1986-1988
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: CONVERTING-ENZYME GENE ; CORONARY HEART-DISEASE ; DELETION POLYMORPHISM ; INSULIN-RESISTANCE ; I/D POLYMORPHISM ; ANGIOTENSIN ; CHINESE ; DYSLIPIDEMIA ; RETINOPATHY ; NEPHROPATHY
英文摘要:

In an attempt to examine the role of an ACE gene insertion/deletion (I/D) polymorphism in type 2 diabetes, we conducted a case-control association study among 132 couple-pairs from northern China. The genotype frequencies for II, ID, and DD were 39.8, 39.8, and 20.3%, respectively, in the case group and 44.8, 44.8, and 10.4% in the control group. The DD frequency was significantly higher in the case group than in the control group (chi(1)(2) = 4.77, P = 0.03), suggesting that the DD genotype is associated with an increased susceptibility to type 2 diabetes in our study population.

语种: 英语
WOS记录号: WOS:000175936700041
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67056
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Harvard Univ, Sch Publ Hlth, Program Populat Genet, Boston, MA 02115 USA
2.Beijing Univ, Affiliated Hosp 3, Div Endocrinol, Beijing, Peoples R China
3.Beijing Univ, Ctr Ecogenet & Reprod Hlth, Beijing, Peoples R China
4.Beijing Univ, Affiliated Hosp 1, Div Endocrinol, Beijing, Peoples R China

Recommended Citation:
Feng, Y,Niu, TH,Xu, X,et al. Insertion/deletion polymorphism of the ACE gene is associated with type 2 diabetes[J]. DIABETES,2002,51(6):1986-1988.
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