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Double measurements of serum HCG concentration and its ratio may predict IVF outcome
Chi, Hongbin; Qiao, Jie; Li, Hongzhen; Liu, Ping; Ma, Caihong
关键词human chorionic gonadotrophin IVF outcome pregnancy ratio
刊名REPRODUCTIVE BIOMEDICINE ONLINE
2010-04-01
DOI10.1016/j.rbmo.2010.01.005
20期:4页:504-509
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Obstetrics & Gynecology ; Reproductive Biology
资助者National Science Fund for Outstanding Youths ; Ministry of Science and Technology of China ; National Science Fund for Outstanding Youths ; Ministry of Science and Technology of China
研究领域[WOS]Obstetrics & Gynecology ; Reproductive Biology
关键词[WOS]HUMAN CHORIONIC-GONADOTROPIN ; IN-VITRO FERTILIZATION ; HETEROTOPIC PREGNANCY ; ECTOPIC PREGNANCY ; EMBRYO-TRANSFER ; ASSISTED REPRODUCTION ; RISK-FACTORS ; IMPLANTATION ; MULTIPLE ; CONCEPTION
英文摘要

Serum human chorionic gonadotrophin (HCG) concentration is nearly always used to predict pregnancy but there is little data on the clinical utility of the ratio of HCG(21)/HCG(14) combined with double measurement of serum HCG. A total of 1762 cycles were retrospectively analysed for serum HCG concentration and ratio of HCG(21)/HCG(14) on days 14 and 21 after embryo transfer to determine whether the ratio combined with concentration is the optimal predictor of pregnancy. The medians of HCG concentration on days 14 and 21 combined with the ratio of HCG(21)/HCG(14) were calculated for non-viable, viable and heterotopic pregnancies. HCG concentrations of 290 IU/l on day 14 and 2970 IU/l on day 21 were regarded as the cut-off values to predict viable pregnancy, and values of 630 and 12,000 IU/l, respectively, were regarded as the cut-off values to predict multiple pregnancy. The ratio of HCG(21)/HCG(14) in the viable pregnancy group was significantly higher than that in the non-viable pregnancy group (15.86 versus 5.27, P < 0.0001). For heterotopic pregnancy, the ratio of HCG(21)/HCG(14) was 11.93. It was concluded that HCG concentration on days 14 and 21 combined with the ratio of HCG(21)/HCG(14) provides a useful predictor of pregnancy outcome. A ratio >15 may predict viable pregnancy. (C) 2010, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

语种英语
所属项目编号30825038 ; 2007BA104800
资助者National Science Fund for Outstanding Youths ; Ministry of Science and Technology of China ; National Science Fund for Outstanding Youths ; Ministry of Science and Technology of China
WOS记录号WOS:000276864900010
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67057
专题北京大学第三临床医学院_生殖医学中心
作者单位Peking Univ, Dept Obstet & Gynecol, Ctr Reprod Med, Hosp 3, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Chi, Hongbin,Qiao, Jie,Li, Hongzhen,et al. Double measurements of serum HCG concentration and its ratio may predict IVF outcome[J]. REPRODUCTIVE BIOMEDICINE ONLINE,2010,20(4):504-509.
APA Chi, Hongbin,Qiao, Jie,Li, Hongzhen,Liu, Ping,&Ma, Caihong.(2010).Double measurements of serum HCG concentration and its ratio may predict IVF outcome.REPRODUCTIVE BIOMEDICINE ONLINE,20(4),504-509.
MLA Chi, Hongbin,et al."Double measurements of serum HCG concentration and its ratio may predict IVF outcome".REPRODUCTIVE BIOMEDICINE ONLINE 20.4(2010):504-509.
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