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Association of the rs10830963 Polymorphism in MTNR1B with Fasting Glucose Levels in Chinese Children and Adolescents
Song, Jie-Yun1,2; Wang, Hai-Jun1; Ma, Jun3,4; Xu, Zhi-Yuan1,2; Hinney, Anke; Hebebrand, Johannes; Wang, Yan1
关键词MTNR1B Glucose Children Adolescents
刊名OBESITY FACTS
2011-06-01
DOI10.1159/000329306
4期:3页:197-203
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism ; Nutrition & Dietetics
研究领域[WOS]Endocrinology & Metabolism ; Nutrition & Dietetics
关键词[WOS]TYPE-2 DIABETES RISK ; BETA-CELL FUNCTION ; PLASMA-GLUCOSE ; COMMON VARIANT ; OBESITY ; INDIVIDUALS ; GENE
英文摘要

Aims: We aimed to identify whether the risk G-allele was associated with fasting glucose level and other pre-diabetic and obesity-related phenotypes in Chinese children and adolescents. Methods: The rs10830963 polymorphism in MTNR1B was genotyped in 2,030 Chinese children and adolescents of two independent studies. Association with fasting glucose levels and risk of impaired fasting glucose (IFG) were initially tested. Subsequently we analyzed the association with fasting insulin, homeostasis model assessment for insulin resistance (HOMA-IR) and for beta cell function (HOMA-B), the quantitative insulin sensitivity check index (QUICK) and obesity-related phenotypes (BMI standard deviation score, waist circumference etc.). Results: The G-allele of rs10830963 was associated with increased fasting glucose level in Chinese children and adolescents (increase of 0.072 mmol/l per G-allele, 95% CI 0.034-0.111, p = 2.46 10(-4)). The G-allele was also associated with an increased risk of IFG (OR = 1.21, 95% CI 1.00-1.46, nominal p = 0.048). We found the glucose-raising G-allele was nominally associated with reduced HOMA-B. No association to other pre-diabetic or obesity-related phenotypes was detected. Conclusions: The rs10830963 polymorphism in MTNR1B was associated with increased fasting glucose and risk of IFG in Chinese children and adolescents. The effect may result from reduced pancreatic beta cell function, but the mechanism awaits further studies.

语种英语
WOS记录号WOS:000292042200003
项目编号30700668 ; 20070001811 ; 2006CB503900 ; 01GS0903 ; NGFNplus 01GS0820
资助机构National Natural Science Foundation of China ; Specialized Research Fund for the Doctoral Program of Higher Education of China ; National Basic Research Program of China (973 program) ; German Bundesministerium fur Bildung und Forschung
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67060
专题北京大学公共卫生学院
北京大学公共卫生学院_公共卫生学院
北京大学医学图书馆_流通阅览部
作者单位1.Peking Univ, Sch Publ Hlth, Div Maternal & Child Hlth, Hlth Sci Ctr, Beijing 100191, Peoples R China
2.Peking Univ, Minist Educ, Key Lab Epidemiol, Beijing 100871, Peoples R China
3.Peking Univ, Inst Child & Adolescent Hlth, Beijing 100871, Peoples R China
4.Univ Duisburg Essen, Dept Child & Adolescent Psychiat, Essen, Germany
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Song, Jie-Yun,Wang, Hai-Jun,Ma, Jun,et al. Association of the rs10830963 Polymorphism in MTNR1B with Fasting Glucose Levels in Chinese Children and Adolescents[J]. OBESITY FACTS,2011,4(3):197-203.
APA Song, Jie-Yun.,Wang, Hai-Jun.,Ma, Jun.,Xu, Zhi-Yuan.,Hinney, Anke.,...&Wang, Yan.(2011).Association of the rs10830963 Polymorphism in MTNR1B with Fasting Glucose Levels in Chinese Children and Adolescents.OBESITY FACTS,4(3),197-203.
MLA Song, Jie-Yun,et al."Association of the rs10830963 Polymorphism in MTNR1B with Fasting Glucose Levels in Chinese Children and Adolescents".OBESITY FACTS 4.3(2011):197-203.
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