IR@PKUHSC  > 北京大学临床肿瘤学院
学科主题临床医学
KIAA0649, a 1A6/DRIM-interacting protein with the oncogenic potential
Yang, L; Zhao, J; Lu, WQ; Li, Y; Du, XJ; Ning, T; Lu, GR; Ke, Y
关键词KIAA0649 1A6/DRIM cancer tumor oncogene protein-protein interaction co-immunoprecipitation tumorigenesis carcinogenesis nuclear
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2005-09-02
DOI10.1016/j.bbrc.2005.06.179
334期:3页:884-890
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]GENE-EXPRESSION ; CELL-LINES ; IDENTIFICATION ; CARCINOMA ; REPEATS ; DRIM
英文摘要

We identified a 1A6/DRIM (down-regulated in metastasis) interacting protein, KIAA0649 during the yeast two-hybrid screen. The interaction between KIAA0649 and 1A6/DRIM was further confirmed by GST-pull-down and co-immunoprecipitation assays. KIAA0649 was originally identified from human brain tissue. However, its biological function remains unknown. In this report, we showed that KIAA0649 mRNA is widely expressed in human multiple tissues and cell lines. We have also demonstrated that KIAA0649 has oncogenic characteristics: it enhances colony formation, allows anchorage-independent growth. Moreover, KIAA0649 exogenous expression in NIH3T3 fibroblasts caused tumor development in nude mice. (c) 2005 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000231226300021
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67064
专题北京大学临床肿瘤学院
作者单位1.Chinese Natl Human Genome Ctr, Beijing 100176, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Inst Canc Res, Beijing 100034, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Cell Biol, Beijing 100083, Peoples R China
4.Peking Univ, Canc Res Ctr, Hlth Sci Ctr, Beijing 100083, Peoples R China
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GB/T 7714
Yang, L,Zhao, J,Lu, WQ,et al. KIAA0649, a 1A6/DRIM-interacting protein with the oncogenic potential[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2005,334(3):884-890.
APA Yang, L.,Zhao, J.,Lu, WQ.,Li, Y.,Du, XJ.,...&Ke, Y.(2005).KIAA0649, a 1A6/DRIM-interacting protein with the oncogenic potential.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,334(3),884-890.
MLA Yang, L,et al."KIAA0649, a 1A6/DRIM-interacting protein with the oncogenic potential".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 334.3(2005):884-890.
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