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学科主题: 临床医学
题名:
KIAA0649, a 1A6/DRIM-interacting protein with the oncogenic potential
作者: Yang, L; Zhao, J; Lu, WQ; Li, Y; Du, XJ; Ning, T; Lu, GR; Ke, Y
关键词: KIAA0649 ; 1A6/DRIM ; cancer ; tumor ; oncogene ; protein-protein interaction ; co-immunoprecipitation ; tumorigenesis ; carcinogenesis ; nuclear
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2005-09-02
DOI: 10.1016/j.bbrc.2005.06.179
卷: 334, 期:3, 页:884-890
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: GENE-EXPRESSION ; CELL-LINES ; IDENTIFICATION ; CARCINOMA ; REPEATS ; DRIM
英文摘要:

We identified a 1A6/DRIM (down-regulated in metastasis) interacting protein, KIAA0649 during the yeast two-hybrid screen. The interaction between KIAA0649 and 1A6/DRIM was further confirmed by GST-pull-down and co-immunoprecipitation assays. KIAA0649 was originally identified from human brain tissue. However, its biological function remains unknown. In this report, we showed that KIAA0649 mRNA is widely expressed in human multiple tissues and cell lines. We have also demonstrated that KIAA0649 has oncogenic characteristics: it enhances colony formation, allows anchorage-independent growth. Moreover, KIAA0649 exogenous expression in NIH3T3 fibroblasts caused tumor development in nude mice. (c) 2005 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000231226300021
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67064
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Chinese Natl Human Genome Ctr, Beijing 100176, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Inst Canc Res, Beijing 100034, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Cell Biol, Beijing 100083, Peoples R China
4.Peking Univ, Canc Res Ctr, Hlth Sci Ctr, Beijing 100083, Peoples R China

Recommended Citation:
Yang, L,Zhao, J,Lu, WQ,et al. KIAA0649, a 1A6/DRIM-interacting protein with the oncogenic potential[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2005,334(3):884-890.
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