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学科主题: 临床医学
题名:
Differentiating malignant vertebral tumours from non-malignancies with CT spectral imaging: a preliminary study
作者: Yuan, Yuan1; Zhang, Yan1; Lang, Ning1; Li, Jianying2; Yuan, Huishu1
关键词: Dual-energy CT ; Spectral imaging ; Differential diagnosis ; Spinal tumors ; Quantitative study
刊名: EUROPEAN RADIOLOGY
发表日期: 2015-10-01
DOI: 10.1007/s00330-015-3726-z
卷: 25, 期:10, 页:2945-2950
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: DUAL-ENERGY CT ; COMPUTED-TOMOGRAPHY ; SPINE ; DIAGNOSIS ; ABDOMEN
英文摘要:

To investigate the value of dual-energy spectral computed tomography (DESCT) for differentiating malignant vertebral tumours from non-malignancies during venous phase.

This study was institutional review board-approved, and written informed consent was obtained from all patients. Thirty-seven patients were examined by DESCT during venous phase. Twenty patients had malignant vertebral tumours, 17 had non-malignant vertebral tumours. The iodine/water densities for the lesion, the lesion-to-muscle ratio, and lesion-to-artery ratio for iodine density measurements were calculated and compared between the two groups with the two-tailed Student t test. A p-value < 0.05 was considered statistically significant. Sensitivity and specificity were compared between the qualitative and quantitative studies.

The iodine density, lesion-to-muscle ratio, and lesion-to-artery ratio of the iodine density measurement for malignant vertebral tumours were significantly different from the respective values for non-malignancies (all p < 0.05). Using 0.52 as the threshold value for the lesion-to-artery iodine density ratio, one could obtain sensitivity of 85 % and specificity of 100 % for differentiating malignant vertebral tumours from non-malignancies, significantly higher than the qualitative diagnosis.

DESCT imaging enables analysis of a number of additional quantitative CT parameters to improve the accuracy for differentiating malignant vertebral tumours from non-malignancies during venous phase.

Dual-energy CT provides a new quantitative method.

CT spectral imaging improves the accuracy of differential diagnosis.

Lesion-to-artery iodine density ratio for malignant vertebral tumours was higher than for non-malignancies.

语种: 英语
WOS记录号: WOS:000360849200016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67069
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Beijing 100191, Peoples R China
2.GE Healthcare, CT Imaging Res Ctr, Beijing, Peoples R China

Recommended Citation:
Yuan, Yuan,Zhang, Yan,Lang, Ning,et al. Differentiating malignant vertebral tumours from non-malignancies with CT spectral imaging: a preliminary study[J]. EUROPEAN RADIOLOGY,2015,25(10):2945-2950.
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