北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 北京大学血液病研究所  > 期刊论文
学科主题: 临床医学
题名:
Correlations of human herpesvirus 6B and CMV infection with acute GVHD in recipients of allogeneic haematopoietic stem cell transplantation
作者: Wang, L-R1; Dong, L-J2; Zhang, M-J3; Lu, D-P1,2
关键词: human herpesvirus 6 ; CMV ; GVHD
刊名: BONE MARROW TRANSPLANTATION
发表日期: 2008-11-01
DOI: 10.1038/bmt.2008.238
卷: 42, 期:10, 页:673-677
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
研究领域[WOS]: Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
关键词[WOS]: BONE-MARROW TRANSPLANTATION ; HOST-DISEASE ; HUMAN-HERPESVIRUS-6 INFECTION ; BLOOD ; PATHOGENESIS ; REACTIVATION ; ASSOCIATION ; ANTIGENEMIA ; INDUCTION ; IMPACT
英文摘要:

Human herpesvirus 6 (HHV-6) and CMV reactivation were monitored in a cohort of 72 consecutive haematopoietic stem cell transplant (HSCT) patients using RQ-PCR and antigenaemia assay, respectively. The association between acute GVHD (aGVHD) and HHV-6B/CMV was evaluated. We found that on day 100 the cumulative incidence of grades I-IV aGVHD, grades II-IV aGVHD and grades III-IV aGVHD was 55.6, 27.8 and 13.9%, respectively. Multivariate analysis indicated that HHV-6B reactivation was closely correlated with a higher probability of grade II-IV aGVHD by day 30 (Hazard ratio (HR), 8.9; 95% confidence interval (CI), 2.6-31.0; P = 0.0006), by day 50 (HR, 6.1; 95% CI, 2.1-17.8; P = 0.0010) and by day 100 (HR, 4.8; 95% CI, 1.7-13.6; P = 0.0028). However, CMV reactivation did not significantly affect the development of aGVHD by day 50 (HR, 0.8; 95% CI, 0.1-6.7; P = 0.8236) and by day 100 (HR, 0.5; 95% CI, 0.1-4.4; P = 0.5330) after HSCT. In conclusion, this study demonstrated that active HHV-6B infection, but not CMV, is significantly associated with an increased risk of aGVHD development after HSCT.

语种: 英语
WOS记录号: WOS:000261196300006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67070
Appears in Collections:北京大学第二临床医学院_北京大学血液病研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Med Coll Wisconsin, Div Biostat, Milwaukee, WI 53226 USA
2.Peking Univ, Inst Haematol, Peoples Hosp, Beijing 100044, Peoples R China
3.Beijing Dao Pei Hosp, Dept Blood & Marrow Transplantat, Beijing, Peoples R China

Recommended Citation:
Wang, L-R,Dong, L-J,Zhang, M-J,et al. Correlations of human herpesvirus 6B and CMV infection with acute GVHD in recipients of allogeneic haematopoietic stem cell transplantation[J]. BONE MARROW TRANSPLANTATION,2008,42(10):673-677.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wang, L-R]'s Articles
[Dong, L-J]'s Articles
[Zhang, M-J]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wang, L-R]‘s Articles
[Dong, L-J]‘s Articles
[Zhang, M-J]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace