学科主题临床医学
Correlations of human herpesvirus 6B and CMV infection with acute GVHD in recipients of allogeneic haematopoietic stem cell transplantation
Wang, L-R1; Dong, L-J2; Zhang, M-J3; Lu, D-P1,2
关键词human herpesvirus 6 CMV GVHD
刊名BONE MARROW TRANSPLANTATION
2008-11-01
DOI10.1038/bmt.2008.238
42期:10页:673-677
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
研究领域[WOS]Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
关键词[WOS]BONE-MARROW TRANSPLANTATION ; HOST-DISEASE ; HUMAN-HERPESVIRUS-6 INFECTION ; BLOOD ; PATHOGENESIS ; REACTIVATION ; ASSOCIATION ; ANTIGENEMIA ; INDUCTION ; IMPACT
英文摘要

Human herpesvirus 6 (HHV-6) and CMV reactivation were monitored in a cohort of 72 consecutive haematopoietic stem cell transplant (HSCT) patients using RQ-PCR and antigenaemia assay, respectively. The association between acute GVHD (aGVHD) and HHV-6B/CMV was evaluated. We found that on day 100 the cumulative incidence of grades I-IV aGVHD, grades II-IV aGVHD and grades III-IV aGVHD was 55.6, 27.8 and 13.9%, respectively. Multivariate analysis indicated that HHV-6B reactivation was closely correlated with a higher probability of grade II-IV aGVHD by day 30 (Hazard ratio (HR), 8.9; 95% confidence interval (CI), 2.6-31.0; P = 0.0006), by day 50 (HR, 6.1; 95% CI, 2.1-17.8; P = 0.0010) and by day 100 (HR, 4.8; 95% CI, 1.7-13.6; P = 0.0028). However, CMV reactivation did not significantly affect the development of aGVHD by day 50 (HR, 0.8; 95% CI, 0.1-6.7; P = 0.8236) and by day 100 (HR, 0.5; 95% CI, 0.1-4.4; P = 0.5330) after HSCT. In conclusion, this study demonstrated that active HHV-6B infection, but not CMV, is significantly associated with an increased risk of aGVHD development after HSCT.

语种英语
WOS记录号WOS:000261196300006
引用统计
被引频次:34[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67070
专题北京大学第二临床医学院_北京大学血液病研究所
作者单位1.Med Coll Wisconsin, Div Biostat, Milwaukee, WI 53226 USA
2.Peking Univ, Inst Haematol, Peoples Hosp, Beijing 100044, Peoples R China
3.Beijing Dao Pei Hosp, Dept Blood & Marrow Transplantat, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Wang, L-R,Dong, L-J,Zhang, M-J,et al. Correlations of human herpesvirus 6B and CMV infection with acute GVHD in recipients of allogeneic haematopoietic stem cell transplantation[J]. BONE MARROW TRANSPLANTATION,2008,42(10):673-677.
APA Wang, L-R,Dong, L-J,Zhang, M-J,&Lu, D-P.(2008).Correlations of human herpesvirus 6B and CMV infection with acute GVHD in recipients of allogeneic haematopoietic stem cell transplantation.BONE MARROW TRANSPLANTATION,42(10),673-677.
MLA Wang, L-R,et al."Correlations of human herpesvirus 6B and CMV infection with acute GVHD in recipients of allogeneic haematopoietic stem cell transplantation".BONE MARROW TRANSPLANTATION 42.10(2008):673-677.
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