北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 北京大学血液病研究所  > 期刊论文
学科主题: 临床医学
题名:
Correlations of human herpesvirus 6B and CMV infection with acute GVHD in recipients of allogeneic haematopoietic stem cell transplantation
作者: Wang, L-R1; Dong, L-J2; Zhang, M-J3; Lu, D-P1,2
关键词: human herpesvirus 6 ; CMV ; GVHD
刊名: BONE MARROW TRANSPLANTATION
发表日期: 2008-11-01
DOI: 10.1038/bmt.2008.238
卷: 42, 期:10, 页:673-677
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
研究领域[WOS]: Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
关键词[WOS]: BONE-MARROW TRANSPLANTATION ; HOST-DISEASE ; HUMAN-HERPESVIRUS-6 INFECTION ; BLOOD ; PATHOGENESIS ; REACTIVATION ; ASSOCIATION ; ANTIGENEMIA ; INDUCTION ; IMPACT
英文摘要:

Human herpesvirus 6 (HHV-6) and CMV reactivation were monitored in a cohort of 72 consecutive haematopoietic stem cell transplant (HSCT) patients using RQ-PCR and antigenaemia assay, respectively. The association between acute GVHD (aGVHD) and HHV-6B/CMV was evaluated. We found that on day 100 the cumulative incidence of grades I-IV aGVHD, grades II-IV aGVHD and grades III-IV aGVHD was 55.6, 27.8 and 13.9%, respectively. Multivariate analysis indicated that HHV-6B reactivation was closely correlated with a higher probability of grade II-IV aGVHD by day 30 (Hazard ratio (HR), 8.9; 95% confidence interval (CI), 2.6-31.0; P = 0.0006), by day 50 (HR, 6.1; 95% CI, 2.1-17.8; P = 0.0010) and by day 100 (HR, 4.8; 95% CI, 1.7-13.6; P = 0.0028). However, CMV reactivation did not significantly affect the development of aGVHD by day 50 (HR, 0.8; 95% CI, 0.1-6.7; P = 0.8236) and by day 100 (HR, 0.5; 95% CI, 0.1-4.4; P = 0.5330) after HSCT. In conclusion, this study demonstrated that active HHV-6B infection, but not CMV, is significantly associated with an increased risk of aGVHD development after HSCT.

语种: 英语
WOS记录号: WOS:000261196300006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67070
Appears in Collections:北京大学第二临床医学院_北京大学血液病研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Med Coll Wisconsin, Div Biostat, Milwaukee, WI 53226 USA
2.Peking Univ, Inst Haematol, Peoples Hosp, Beijing 100044, Peoples R China
3.Beijing Dao Pei Hosp, Dept Blood & Marrow Transplantat, Beijing, Peoples R China

Recommended Citation:
Wang, L-R,Dong, L-J,Zhang, M-J,et al. Correlations of human herpesvirus 6B and CMV infection with acute GVHD in recipients of allogeneic haematopoietic stem cell transplantation[J]. BONE MARROW TRANSPLANTATION,2008,42(10):673-677.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wang, L-R]'s Articles
[Dong, L-J]'s Articles
[Zhang, M-J]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wang, L-R]‘s Articles
[Dong, L-J]‘s Articles
[Zhang, M-J]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace