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学科主题: 临床医学
题名:
The Expression of Histone Demethylase JMJD1A in Renal Cell Carcinoma
作者: Guo, X.1,2; Shi, M.2; Sun, L.2; Wang, Y.2; Gui, Y.2; Cai, Z.2; Duan, X.1
关键词: renal cell carcinoma ; histone demethylase ; JMJD1A ; hypoxia-inducible factor ; iron
刊名: NEOPLASMA
发表日期: 2011
DOI: 10.4149/neo_2011_02_153
卷: 58, 期:2, 页:153-157
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: HYPOXIA-INDUCIBLE FACTORS ; CANCER ; NICKEL ; PROLIFERATION ; DERNETHYLASE ; ASCORBATE ; DEPLETION ; TARGETS ; HIF
英文摘要:

Background: Hypoxia-inducible factor la has been shown to play a central role in RCC tumorigenesis by acting as a transcription factor. Histone demethylase JMJD1A is an iron- and 2-oxoglutarate-dependent dioxygenase which catalyze the demethylation of mono- and dimethylated H3K9. JMJD1A can be upregulated by hypoxia via HIF-1 and associated with cancer.

The expression of JMJD1A was determined in 10 kidney cancer tissue and adjacent tissue by quantitative polymerase chain reaction, western blotting and immunohistochemistry. Furthermore, the expression of JMJD1A was investigated in cell line 786-0 through adding nickle or cobalt ion to mimic hypoxic environment.

The expression of JMJD1A was higher in cancer tissue than adjacent tissue, and in hypoxic environment than normal environment. In cancer tissue, the JMJD1A mainly located around blood vessels which indicated that JMJD1A is involved tumor angiogenesis. Conclusion: the increased expression of JMJD1A might be associated with the progression of kidney cancer.

语种: 英语
所属项目编号: 30900817 ; 2010002
项目资助者: National Natural Science Foundation of China ; Guangdong Key Laboratory of Male Reproductive Medicine and Genetics
WOS记录号: WOS:000290695700010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67071
Appears in Collections:北京大学深圳医院_期刊论文

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作者单位: 1.Hebei Normal Univ, Coll Life Sci, Lab Mol Iron Metab, Shijiazhuang 050016, Hebei, Peoples R China
2.Peking Univ, Shenzhen Hosp, Guangdong Key Lab Male Reprod Med & Genet, Shenzhen 518036, Peoples R China

Recommended Citation:
Guo, X.,Shi, M.,Sun, L.,et al. The Expression of Histone Demethylase JMJD1A in Renal Cell Carcinoma[J]. NEOPLASMA,2011,58(2):153-157.
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