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学科主题临床医学
The Expression of Histone Demethylase JMJD1A in Renal Cell Carcinoma
Guo, X.1,2; Shi, M.2; Sun, L.2; Wang, Y.2; Gui, Y.2; Cai, Z.2; Duan, X.1
关键词renal cell carcinoma histone demethylase JMJD1A hypoxia-inducible factor iron
刊名NEOPLASMA
2011
DOI10.4149/neo_2011_02_153
58期:2页:153-157
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]HYPOXIA-INDUCIBLE FACTORS ; CANCER ; NICKEL ; PROLIFERATION ; DERNETHYLASE ; ASCORBATE ; DEPLETION ; TARGETS ; HIF
英文摘要

Background: Hypoxia-inducible factor la has been shown to play a central role in RCC tumorigenesis by acting as a transcription factor. Histone demethylase JMJD1A is an iron- and 2-oxoglutarate-dependent dioxygenase which catalyze the demethylation of mono- and dimethylated H3K9. JMJD1A can be upregulated by hypoxia via HIF-1 and associated with cancer.

The expression of JMJD1A was determined in 10 kidney cancer tissue and adjacent tissue by quantitative polymerase chain reaction, western blotting and immunohistochemistry. Furthermore, the expression of JMJD1A was investigated in cell line 786-0 through adding nickle or cobalt ion to mimic hypoxic environment.

The expression of JMJD1A was higher in cancer tissue than adjacent tissue, and in hypoxic environment than normal environment. In cancer tissue, the JMJD1A mainly located around blood vessels which indicated that JMJD1A is involved tumor angiogenesis. Conclusion: the increased expression of JMJD1A might be associated with the progression of kidney cancer.

语种英语
WOS记录号WOS:000290695700010
项目编号30900817 ; 2010002
资助机构National Natural Science Foundation of China ; Guangdong Key Laboratory of Male Reproductive Medicine and Genetics
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被引频次:34[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67071
专题北京大学深圳医院
作者单位1.Hebei Normal Univ, Coll Life Sci, Lab Mol Iron Metab, Shijiazhuang 050016, Hebei, Peoples R China
2.Peking Univ, Shenzhen Hosp, Guangdong Key Lab Male Reprod Med & Genet, Shenzhen 518036, Peoples R China
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Guo, X.,Shi, M.,Sun, L.,et al. The Expression of Histone Demethylase JMJD1A in Renal Cell Carcinoma[J]. NEOPLASMA,2011,58(2):153-157.
APA Guo, X..,Shi, M..,Sun, L..,Wang, Y..,Gui, Y..,...&Duan, X..(2011).The Expression of Histone Demethylase JMJD1A in Renal Cell Carcinoma.NEOPLASMA,58(2),153-157.
MLA Guo, X.,et al."The Expression of Histone Demethylase JMJD1A in Renal Cell Carcinoma".NEOPLASMA 58.2(2011):153-157.
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