IR@PKUHSC  > 北京大学基础医学院  > 药理学系
学科主题基础医学
Effects of a microRNA binding site polymorphism in SLC19A1 on methotrexate concentrations in Chinese children with acute lymphoblastic leukemia
Wang, Shu-mei1; Sun, Lu-lu1; Zeng, Wei-xin1; Wu, Wan-shui2; Zhang, Guo-liang3
关键词Acute lymphoblastic leukemia Methotrexate MicroRNA Solute carrier family 19 member 1
刊名MEDICAL ONCOLOGY
2014-07-01
DOI10.1007/s12032-014-0062-0
31期:7
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
资助者Beijing Shijitan Hospital, Capital Medical University ; Beijing Shijitan Hospital, Capital Medical University
研究领域[WOS]Oncology
关键词[WOS]REDUCED FOLATE CARRIER ; GENE ; EXPRESSION ; PHARMACOGENOMICS ; RESISTANCE ; TRANSPORT ; MECHANISM ; THERAPY
英文摘要

MicroRNAs (miRNAs) are a class of short non-coding RNA that can specially bind to the 3′-untranslated region of target mRNAs and regulate gene expression at the posttranscriptional level. This study investigated the effects of a miRNA binding site polymorphism (rs1051296) in solute carrier family 19, member 1 (SLC19A1) on serum methotrexate (MTX) concentrations in Chinese children with acute lymphoblastic leukemia (ALL). Genotyping for SLC19A1 rs1051296 G>T in 131 children with ALL was performed using the Sequenom MassArray system. A total of 131 patients received high-dose MTX treatment, and serum MTX concentrations were measured by a fluorescence polarization immunoassay 24 (MTX C-24h) and 42 h (MTX C-42h) after administration. The frequency of the rs1051296 T allele observed in this study (46.2 %) was significantly lower than that previously observed in a European population (60.7 %, P = 0.002). There was significant association between rs1051296 G>T and MTX C-24h (29.97, 32.34, and 39.01 mu mol/L for GG, GT, and TT genotypes, respectively, P = 0.04). The percentage of patients with an MTX concentration above the therapeutic threshold (40 mu mol/L) was significantly lower in GG carriers compared with that in GT and TT carriers 8.6 % for GG genotype vs. 26.8 and 40.0 % for CT and TT genotypes, respectively, P = 0.02). Delayed elimination of MTX (C-42h > 1 mu mol/L) was less frequent in GG carriers than in GT and TT carriers. Rs1051296 G>T was associated with MTX plasma concentration, suggesting that miRNAs might be involved in the post-transcriptional regulation of SLC19A1.

语种英语
所属项目编号2013-QB02
资助者Beijing Shijitan Hospital, Capital Medical University ; Beijing Shijitan Hospital, Capital Medical University
WOS记录号WOS:000339003700009
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67074
Collection北京大学基础医学院_药理学系
作者单位1.Capital Med Univ, Beijing Shijitan Hosp, Dept Pharm, Beijing, Peoples R China
2.Capital Med Univ, Beijing Shijitan Hosp, Dept Pediat, Beijing, Peoples R China
3.Beijing Univ, Basic Med Sch, Dept Pharmacol, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Wang, Shu-mei,Sun, Lu-lu,Zeng, Wei-xin,et al. Effects of a microRNA binding site polymorphism in SLC19A1 on methotrexate concentrations in Chinese children with acute lymphoblastic leukemia[J]. MEDICAL ONCOLOGY,2014,31(7).
APA Wang, Shu-mei,Sun, Lu-lu,Zeng, Wei-xin,Wu, Wan-shui,&Zhang, Guo-liang.(2014).Effects of a microRNA binding site polymorphism in SLC19A1 on methotrexate concentrations in Chinese children with acute lymphoblastic leukemia.MEDICAL ONCOLOGY,31(7).
MLA Wang, Shu-mei,et al."Effects of a microRNA binding site polymorphism in SLC19A1 on methotrexate concentrations in Chinese children with acute lymphoblastic leukemia".MEDICAL ONCOLOGY 31.7(2014).
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