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学科主题: 临床医学
题名:
An approach to enhancing the phototoxicity of a novel hypocrellin congener to MGC803 cells
作者: Yang, HY; Zhang, WG; Ma, LP; Wang, SW; Zhang, ZY
关键词: MGC803 cells ; hypocrellin congener ; photodynamic therapy ; photosensitizer
刊名: DYES AND PIGMENTS
发表日期: 2001-11-01
卷: 51, 期:2-3, 页:103-110
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Applied ; Engineering, Chemical ; Materials Science, Textiles
研究领域[WOS]: Chemistry ; Engineering ; Materials Science
关键词[WOS]: WILD-TYPE P53 ; PHOTODYNAMIC THERAPY ; GENE-TRANSFER ; CANCER-CELLS ; MUTANT P53 ; APOPTOSIS ; CARCINOMA ; GROWTH ; RADIOSENSITIVITY ; EXPRESSION
英文摘要:

A novel photosensitizer, 2-butylamino-2-demethoxy-hypocrellin A (2-BA-2-DMHA) has been found to cause high phototoxicity to MGC803 cells mainly via apoptosis. To increase the efficiency of 2-BA-2-DMHA-mediated photodynamic therapy (PDT) to MGC803 cells. we transferred the retrovirus-mediated wild-type p53 gene to MGC803 cells. As a result. we found that wild-type p53 infected MGC803 cells expressed exogenous p53 mRNA and a high level of p53 protein. Overexpression of the gene made the cells more sensitive to 2-BA-2-DMHA-mediated PDT. At a concentration of 0.25 muM 2-BA-2-DMHA with a red light of 10 J cm(-2) (gimel = 600-700 nm), the wild-type p53 infected MGC803 cell survival was 4 times lower than that associated with the parent and the empty vector infected MGC 803 cell survival. In addition, apoptosis appeared earlier in wild-type p53 infected MGC803 cells. (C) 2001 Elsevier Science Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000172497700006
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67083
Appears in Collections:北京大学第二临床医学院_中心实验室_期刊论文

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作者单位: 1.Acad Sinica, Inst Biophys, Beijing 100101, Peoples R China
2.Beijing Med Univ, Peoples Hosp, Cent Lab, Beijing 100044, Peoples R China

Recommended Citation:
Yang, HY,Zhang, WG,Ma, LP,et al. An approach to enhancing the phototoxicity of a novel hypocrellin congener to MGC803 cells[J]. DYES AND PIGMENTS,2001,51(2-3):103-110.
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