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An approach to enhancing the phototoxicity of a novel hypocrellin congener to MGC803 cells
Yang, HY; Zhang, WG; Ma, LP; Wang, SW; Zhang, ZY
关键词MGC803 cells hypocrellin congener photodynamic therapy photosensitizer
刊名DYES AND PIGMENTS
2001-11-01
51期:2-3页:103-110
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Applied ; Engineering, Chemical ; Materials Science, Textiles
研究领域[WOS]Chemistry ; Engineering ; Materials Science
关键词[WOS]WILD-TYPE P53 ; PHOTODYNAMIC THERAPY ; GENE-TRANSFER ; CANCER-CELLS ; MUTANT P53 ; APOPTOSIS ; CARCINOMA ; GROWTH ; RADIOSENSITIVITY ; EXPRESSION
英文摘要

A novel photosensitizer, 2-butylamino-2-demethoxy-hypocrellin A (2-BA-2-DMHA) has been found to cause high phototoxicity to MGC803 cells mainly via apoptosis. To increase the efficiency of 2-BA-2-DMHA-mediated photodynamic therapy (PDT) to MGC803 cells. we transferred the retrovirus-mediated wild-type p53 gene to MGC803 cells. As a result. we found that wild-type p53 infected MGC803 cells expressed exogenous p53 mRNA and a high level of p53 protein. Overexpression of the gene made the cells more sensitive to 2-BA-2-DMHA-mediated PDT. At a concentration of 0.25 muM 2-BA-2-DMHA with a red light of 10 J cm(-2) (gimel = 600-700 nm), the wild-type p53 infected MGC803 cell survival was 4 times lower than that associated with the parent and the empty vector infected MGC 803 cell survival. In addition, apoptosis appeared earlier in wild-type p53 infected MGC803 cells. (C) 2001 Elsevier Science Ltd. All rights reserved.

语种英语
WOS记录号WOS:000172497700006
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67083
专题北京大学第二临床医学院_中心实验室
作者单位1.Acad Sinica, Inst Biophys, Beijing 100101, Peoples R China
2.Beijing Med Univ, Peoples Hosp, Cent Lab, Beijing 100044, Peoples R China
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GB/T 7714
Yang, HY,Zhang, WG,Ma, LP,et al. An approach to enhancing the phototoxicity of a novel hypocrellin congener to MGC803 cells[J]. DYES AND PIGMENTS,2001,51(2-3):103-110.
APA Yang, HY,Zhang, WG,Ma, LP,Wang, SW,&Zhang, ZY.(2001).An approach to enhancing the phototoxicity of a novel hypocrellin congener to MGC803 cells.DYES AND PIGMENTS,51(2-3),103-110.
MLA Yang, HY,et al."An approach to enhancing the phototoxicity of a novel hypocrellin congener to MGC803 cells".DYES AND PIGMENTS 51.2-3(2001):103-110.
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