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学科主题: 临床医学
题名:
Attention changes in epilepsy patients following 3-month topiramate or valproate treatment revealed by event-related potential
作者: Sun, Wei1; Wang, Yuping1; Wang, Weiwei2; Wu, Xun2
关键词: epilepsy ; topiramate ; valproate ; event-related potential ; N170 ; N270 ; cognitive ; attention
刊名: INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
发表日期: 2008-06-01
DOI: 10.1016/j.ijpsycho.2008.02.003
卷: 68, 期:3, 页:235-241
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Social Sciences ; Science & Technology
类目[WOS]: Psychology, Biological ; Neurosciences ; Physiology ; Psychology ; Psychology, Experimental
研究领域[WOS]: Psychology ; Neurosciences & Neurology ; Physiology
关键词[WOS]: COGNITIVE IMPAIRMENT ; HUMAN BRAIN ; ANTIEPILEPTIC DRUGS ; MISMATCH NEGATIVITY ; FACE PERCEPTION ; N270 ; TASK ; DISCRIMINATION ; COMPONENT ; CHILDREN
英文摘要:

The present study was designed to reveal changes of cognitive processes in epilepsy (EP) patients with Topiramate (TPM) or Valproate (VPA) treatment using Wechsler Adult Intelligence Scale (WAIS-CR) and event-related potential (ERP). Thirty untreated epilepsy patients were randomly divided into two groups receiving TPM or VPA, respectively. Fifteen healthy volunteers were included as controls. All the patients were examined by WAIS-CR and ERP before and 3 months after drug treatment. Controls were examined by ERP at the time recruited into the study and 3 months later. Unfamiliar grey-scale photographs of faces (front view) were used as stimuli. ERP were recorded at the same time. Mean Intelligence Quotient (IQ) in TPM group decreased after the 3-month treatment (90.40 vs. 81.00, P<0.05). One component of ERP-P300 was smaller in epilepsy patients than controls (P<0.05), but remained unchanged after TPM or VPA treatment (P>0.05). A delayed and smaller N270 was detected in patients compared to controls (P<0.05). After 3 months TPM treatment, it decreased further compared to before treatment (P< 0.05). N170 was lower in patient groups, and it became lower after TPM treatment than before. Our results demonstrate that in all epilepsy patients with mild cognitive impairment ERP changes were found. TPM affected the cognitive functions in epilepsy patients reflected by the decreased full-scale intelligence quotient (FIQ). The imperative effects of TPM on visual perception function reflected by N170 were more obvious than that of VIA. Attention reflected by N270 was impaired after TPM treatment. (C) 2008 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000256092900008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67091
Appears in Collections:北京大学第一临床医学院_神经内科_期刊论文

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作者单位: 1.Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing 100053, Peoples R China
2.Peking Univ, Hosp 1, Dept Neurol, Beijing 100034, Peoples R China

Recommended Citation:
Sun, Wei,Wang, Yuping,Wang, Weiwei,et al. Attention changes in epilepsy patients following 3-month topiramate or valproate treatment revealed by event-related potential[J]. INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY,2008,68(3):235-241.
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