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学科主题: 公共卫生
题名:
Targeting-Triggered Porphysome Nanostructure Disruption for Activatable Photodynamic Therapy
作者: Jin, Cheng S.1,2,3,4; Cui, Liyang1,2,5,6; Wang, Fan6; Chen, Juan1,2; Zheng, Gang1,2,3,4,5
刊名: ADVANCED HEALTHCARE MATERIALS
发表日期: 2014-08-01
DOI: 10.1002/adhm.201300651
卷: 3, 期:8, 页:1240-1249
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Engineering, Biomedical ; Nanoscience & Nanotechnology ; Materials Science, Biomaterials
研究领域[WOS]: Engineering ; Science & Technology - Other Topics ; Materials Science
关键词[WOS]: SINGLET OXYGEN PRODUCTION ; FOLATE-CONJUGATED LIPOSOMES ; MOLECULAR BEACON ; RECEPTOR ; CANCER ; AGENTS ; TUMORS ; PHOTOSENSITIZER ; NANOPARTICLES ; NANOVESICLES
英文摘要:

Photodynamic therapy (PDT) and photothermal therapy (PTT) possess advantages over the conventional therapies with additional treatment selectivity achieved with local laser irradiation. Comparing to PTT that ablates target tissue via thermal necrosis, PDT induces target cell death via singlet oxygen without damaging the underling connective tissue, thus preserving its biological function. Activatable photosensitizers provide an additional level of treatment selectivity via the disease-associated activation mechanism. In this study, folate-conjugated porphysomes are introduced as targeting-triggered activatable nano-sized beacons for PDT. Porphysomes are reported previously as the most stable and efficient delivery system of porphyrin, but their nanostructure converts the singlet oxygen generation mechanism to thermal ablation mechanism. By folate-receptor-mediated endocytosis, folate-porphysomes are internalized into cells rapidly and resulted in efficient disruption of nanostructures, thus switching back on the photodynamic activity of the densely packed porphyrins for effective PDT. In both in vitro and in vivo studies, folate-porphysomes can achieve folate receptor-selective PDT efficacy, which proves the robustness of targeting-triggered PDT activation of porphysome nanostructure for highly selective tumor ablation. The formulation of porphysomes can be modified with other targeting ligands as activatable photosensitizers for personalized treatment in future.

语种: 英语
所属项目编号: W81XWH-13-1-0442
项目资助者: Canadian Institute of Health Research ; Canadian Space Agency ; Prostate Cancer foundation of Canada ; Natural Sciences and Engineering Research Council of Canada ; Canadian Foundation for Innovation ; US Army ; MaRS Innovation ; Canadian Cancer Society Research Institute ; Princess Margaret Cancer Center Foundation ; Joey and Toby Tanenbaum/Brazilian Ball Chair in Prostate Cancer Research
WOS记录号: WOS:000340550500013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67101
Appears in Collections:北京大学医药卫生分析中心_期刊论文

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作者单位: 1.Univ Hlth Network, Ontario Canc Inst, Toronto, ON M5G 1L7, Canada
2.Univ Hlth Network, Techna Inst, Toronto, ON M5G 1L7, Canada
3.Univ Toronto, Dept Pharmaceut Sci, Leslie Dan Fac Pharm, Toronto, ON M5G 1L7, Canada
4.Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON M5G 1L7, Canada
5.Univ Toronto, Dept Med Biophys, Toronto, ON M5G 1L7, Canada
6.Peking Univ, Med Isotopes Res Ctr, Beijing 10010, Peoples R China

Recommended Citation:
Jin, Cheng S.,Cui, Liyang,Wang, Fan,et al. Targeting-Triggered Porphysome Nanostructure Disruption for Activatable Photodynamic Therapy[J]. ADVANCED HEALTHCARE MATERIALS,2014,3(8):1240-1249.
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