北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 核医学科  > 期刊论文
学科主题: 临床医学
题名:
Detection of pulmonary metastases with the novel radiolabeled molecular probe, Tc-99m-RRL
作者: Yao, Ning1; Yan, Ping1; Wang, Rong-Fu1; Zhang, Chun-Li1; Ma, Chao1; Chen, Xue-Qi1; Zhao, Qian2; Hao, Pan1
关键词: Tc-99m ; peptide ; tumor angiogenesis ; lung metastasis ; non-invasive imaging
刊名: INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
发表日期: 2015
卷: 8, 期:2, 页:1726-1736
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: PROSTATE CARCINOMA ; BRAIN-TUMORS ; CANCER-CELLS ; PET ; INFLAMMATION ; PEPTIDE ; MICE
英文摘要:

Background: To improve the detection of pulmonary metastases, experimental blood-borne pulmonary metastasis mouse models were established using three intravenously administered cell lines. In a previous study we demonstrated that Tc-99m-radiolabeled arginine-arginine-leucine (RRL) could be used to non-invasively image malignant tumors. Methods: Tc-99m-RRL was prepared and injected intravenously in mice with pulmonary metastases that arose from the intravenous injection of HepG2, B16, and Hela cells. The bio-distribution and imaging of Tc-99m-RRL were determined in different pulmonary metastases mouse models and in normal mice. Results: Tc-99m-RRL exhibited higher uptake values in the lungs of pulmonary metastatic mice compared to normal mice (P<0.05; 3.92 +/- 0.48% ID/g 2 h post-injection and 3.89 +/- 0.36% ID/g 4 h post-injection in metastatic hepatic carcinoma [HepG2]-bearing lungs; 5.49 +/- 0.84% ID/g 2 h post-injection and 5.11 +/- 0.75% ID/g 4 h post-injection in metastatic melanoma [B16]bearing lungs; 3.72 +/- 0.52% ID/g 2 h post-injection and 3.51 +/- 0.35% ID/g 4 h post-injection in metastatic cervical carcinoma [Hela]-bearing lungs; 2.38 +/- 0.20% ID/g 2 h post-injection and 2.11 +/- 0.24% ID/g 4 h post-injection in normal lungs). The pulmonary metastatic lesions were clearly visualized using Tc-99m-RRL. Conclusions: Tc-99m-RRL exhibited favorable metastatic tumor targeting and imaging properties, thus highlighting its potential as an effective imaging probe for detection of pulmonary metastases. Tc-99m-RRL can be used as a reasonable supplement to F-18-FDG imaging in the non-invasive imaging of tumor angiogenesis.

语种: 英语
所属项目编号: NSFC 30870729 ; 81071183 ; 2011-YQ030114 ; 2011YQ03011409 ; BMU20120297 ; 120201 ; 2014BAA03B03
项目资助者: Natural Science Foundation of China ; Ministry of Science and Technology of China ; Research Fund for the Medicine and Engineering of Peking University ; Research Fund Key Laboratory of Radiopharmaceuticals (Beijing Normal University) ; Ministry of Education, Department of Chemistry, Beijing Normal University, Beijing, China ; Fund for Key Projects in the National Science &amp ; Technology Pillar Program during the Twelfth Five-year Plan Period
WOS记录号: WOS:000355306000018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67103
Appears in Collections:北京大学第一临床医学院_核医学科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Hosp 1, Dept Nucl Med, Beijing 100034, Peoples R China
2.Ningxia Med Univ, Dept Nucl Med, Gen Hosp, Ningxia 750004, Peoples R China

Recommended Citation:
Yao, Ning,Yan, Ping,Wang, Rong-Fu,et al. Detection of pulmonary metastases with the novel radiolabeled molecular probe, Tc-99m-RRL[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,2015,8(2):1726-1736.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Yao, Ning]'s Articles
[Yan, Ping]'s Articles
[Wang, Rong-Fu]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Yao, Ning]‘s Articles
[Yan, Ping]‘s Articles
[Wang, Rong-Fu]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace