北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 核医学科  > 期刊论文
学科主题: 临床医学
题名:
Detection of pulmonary metastases with the novel radiolabeled molecular probe, Tc-99m-RRL
作者: Yao, Ning1; Yan, Ping1; Wang, Rong-Fu1; Zhang, Chun-Li1; Ma, Chao1; Chen, Xue-Qi1; Zhao, Qian2; Hao, Pan1
关键词: Tc-99m ; peptide ; tumor angiogenesis ; lung metastasis ; non-invasive imaging
刊名: INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
发表日期: 2015
卷: 8, 期:2, 页:1726-1736
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: PROSTATE CARCINOMA ; BRAIN-TUMORS ; CANCER-CELLS ; PET ; INFLAMMATION ; PEPTIDE ; MICE
英文摘要:

Background: To improve the detection of pulmonary metastases, experimental blood-borne pulmonary metastasis mouse models were established using three intravenously administered cell lines. In a previous study we demonstrated that Tc-99m-radiolabeled arginine-arginine-leucine (RRL) could be used to non-invasively image malignant tumors. Methods: Tc-99m-RRL was prepared and injected intravenously in mice with pulmonary metastases that arose from the intravenous injection of HepG2, B16, and Hela cells. The bio-distribution and imaging of Tc-99m-RRL were determined in different pulmonary metastases mouse models and in normal mice. Results: Tc-99m-RRL exhibited higher uptake values in the lungs of pulmonary metastatic mice compared to normal mice (P<0.05; 3.92 +/- 0.48% ID/g 2 h post-injection and 3.89 +/- 0.36% ID/g 4 h post-injection in metastatic hepatic carcinoma [HepG2]-bearing lungs; 5.49 +/- 0.84% ID/g 2 h post-injection and 5.11 +/- 0.75% ID/g 4 h post-injection in metastatic melanoma [B16]bearing lungs; 3.72 +/- 0.52% ID/g 2 h post-injection and 3.51 +/- 0.35% ID/g 4 h post-injection in metastatic cervical carcinoma [Hela]-bearing lungs; 2.38 +/- 0.20% ID/g 2 h post-injection and 2.11 +/- 0.24% ID/g 4 h post-injection in normal lungs). The pulmonary metastatic lesions were clearly visualized using Tc-99m-RRL. Conclusions: Tc-99m-RRL exhibited favorable metastatic tumor targeting and imaging properties, thus highlighting its potential as an effective imaging probe for detection of pulmonary metastases. Tc-99m-RRL can be used as a reasonable supplement to F-18-FDG imaging in the non-invasive imaging of tumor angiogenesis.

语种: 英语
所属项目编号: NSFC 30870729 ; 81071183 ; 2011-YQ030114 ; 2011YQ03011409 ; BMU20120297 ; 120201 ; 2014BAA03B03
项目资助者: Natural Science Foundation of China ; Ministry of Science and Technology of China ; Research Fund for the Medicine and Engineering of Peking University ; Research Fund Key Laboratory of Radiopharmaceuticals (Beijing Normal University) ; Ministry of Education, Department of Chemistry, Beijing Normal University, Beijing, China ; Fund for Key Projects in the National Science &amp ; Technology Pillar Program during the Twelfth Five-year Plan Period
WOS记录号: WOS:000355306000018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67103
Appears in Collections:北京大学第一临床医学院_核医学科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Hosp 1, Dept Nucl Med, Beijing 100034, Peoples R China
2.Ningxia Med Univ, Dept Nucl Med, Gen Hosp, Ningxia 750004, Peoples R China

Recommended Citation:
Yao, Ning,Yan, Ping,Wang, Rong-Fu,et al. Detection of pulmonary metastases with the novel radiolabeled molecular probe, Tc-99m-RRL[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,2015,8(2):1726-1736.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Yao, Ning]'s Articles
[Yan, Ping]'s Articles
[Wang, Rong-Fu]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Yao, Ning]‘s Articles
[Yan, Ping]‘s Articles
[Wang, Rong-Fu]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace