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学科主题临床医学
Detection of pulmonary metastases with the novel radiolabeled molecular probe, Tc-99m-RRL
Yao, Ning1; Yan, Ping1; Wang, Rong-Fu1; Zhang, Chun-Li1; Ma, Chao1; Chen, Xue-Qi1; Zhao, Qian2; Hao, Pan1
关键词Tc-99m peptide tumor angiogenesis lung metastasis non-invasive imaging
刊名INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
2015
8期:2页:1726-1736
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]PROSTATE CARCINOMA ; BRAIN-TUMORS ; CANCER-CELLS ; PET ; INFLAMMATION ; PEPTIDE ; MICE
英文摘要

Background: To improve the detection of pulmonary metastases, experimental blood-borne pulmonary metastasis mouse models were established using three intravenously administered cell lines. In a previous study we demonstrated that Tc-99m-radiolabeled arginine-arginine-leucine (RRL) could be used to non-invasively image malignant tumors. Methods: Tc-99m-RRL was prepared and injected intravenously in mice with pulmonary metastases that arose from the intravenous injection of HepG2, B16, and Hela cells. The bio-distribution and imaging of Tc-99m-RRL were determined in different pulmonary metastases mouse models and in normal mice. Results: Tc-99m-RRL exhibited higher uptake values in the lungs of pulmonary metastatic mice compared to normal mice (P<0.05; 3.92 +/- 0.48% ID/g 2 h post-injection and 3.89 +/- 0.36% ID/g 4 h post-injection in metastatic hepatic carcinoma [HepG2]-bearing lungs; 5.49 +/- 0.84% ID/g 2 h post-injection and 5.11 +/- 0.75% ID/g 4 h post-injection in metastatic melanoma [B16]bearing lungs; 3.72 +/- 0.52% ID/g 2 h post-injection and 3.51 +/- 0.35% ID/g 4 h post-injection in metastatic cervical carcinoma [Hela]-bearing lungs; 2.38 +/- 0.20% ID/g 2 h post-injection and 2.11 +/- 0.24% ID/g 4 h post-injection in normal lungs). The pulmonary metastatic lesions were clearly visualized using Tc-99m-RRL. Conclusions: Tc-99m-RRL exhibited favorable metastatic tumor targeting and imaging properties, thus highlighting its potential as an effective imaging probe for detection of pulmonary metastases. Tc-99m-RRL can be used as a reasonable supplement to F-18-FDG imaging in the non-invasive imaging of tumor angiogenesis.

语种英语
WOS记录号WOS:000355306000018
项目编号NSFC 30870729 ; 81071183 ; 2011-YQ030114 ; 2011YQ03011409 ; BMU20120297 ; 120201 ; 2014BAA03B03
资助机构Natural Science Foundation of China ; Ministry of Science and Technology of China ; Research Fund for the Medicine and Engineering of Peking University ; Research Fund Key Laboratory of Radiopharmaceuticals (Beijing Normal University) ; Ministry of Education, Department of Chemistry, Beijing Normal University, Beijing, China ; Fund for Key Projects in the National Science &amp ; Technology Pillar Program during the Twelfth Five-year Plan Period
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67103
专题北京大学第一临床医学院_核医学科
作者单位1.Peking Univ, Hosp 1, Dept Nucl Med, Beijing 100034, Peoples R China
2.Ningxia Med Univ, Dept Nucl Med, Gen Hosp, Ningxia 750004, Peoples R China
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Yao, Ning,Yan, Ping,Wang, Rong-Fu,et al. Detection of pulmonary metastases with the novel radiolabeled molecular probe, Tc-99m-RRL[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,2015,8(2):1726-1736.
APA Yao, Ning.,Yan, Ping.,Wang, Rong-Fu.,Zhang, Chun-Li.,Ma, Chao.,...&Hao, Pan.(2015).Detection of pulmonary metastases with the novel radiolabeled molecular probe, Tc-99m-RRL.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,8(2),1726-1736.
MLA Yao, Ning,et al."Detection of pulmonary metastases with the novel radiolabeled molecular probe, Tc-99m-RRL".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 8.2(2015):1726-1736.
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