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学科主题: 临床医学
题名:
Prognostic value and characterization of the ovarian cancer-specific antigen CA166-9
作者: Ji, Fangxing1; Chang, Xiaohong2; Liu, Caiyun2; Meng, Lin1; Qu, Like1; Wu, Jian1; Liu, Chanzhen2; Cui, Heng2; Shou, Chengchao1
关键词: ovarian cancer ; CA166-9 antigen ; prognosis ; antigen cloning ; IGHG1
刊名: INTERNATIONAL JOURNAL OF ONCOLOGY
发表日期: 2015-10-01
DOI: 10.3892/ijo.2015.3115
卷: 47, 期:4, 页:1405-1415
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: ANTITUMOR IMMUNE-RESPONSES ; IMMUNOGLOBULIN-G ; CELL-LINES ; MONOCLONAL-ANTIBODIES ; GENE-EXPRESSION ; CARCINOMA-CELLS ; FUSION PROTEIN ; PROLIFERATION ; INHIBITION ; DIAGNOSIS
英文摘要:

COC166-9 is an ovarian cancer-specific monoclonal antibody, and C0C166-9-based immunotherapy has been shown to possess killing effects against ovarian cancer cells in vitro and in vivo. However the antigen recognized by COC166-9 (COC166-9-Ag, CA166-9) has not been identified and the clinical significance of CA166-9 expression remains unknown. We found that CA166-9 was positive in 53.1% of ovarian cancer tissues. Expression of CA166-9 was strongly correlated with the cancer recurrence (P<0.001). Patients with positive CA166-9 had substantially shorter overall survival (P=0.026) and disease-free survival (P=0.002). CA166-9 was also shown to be an independent predictive factor for overall survival (HR=2.454, P=0.016) and disease-free survival (HR=2.331, P=0.021). We identified CA166-9 as human immunoglobulin gamma-1 heavy chain constant region (IGHG1). Purified IGHG1 promoted proliferation, migration, and invasion of CA166-9-negative ovarian cancer HOC1A cells, whereas it had minimal effects on the phenotypes of CA166-9-positive ovarian cancer CAOV-3 cells. In addition, overexpression of IGHG1 enhanced migration of ovarian cancer cells. On the contrary, COC166-9 inhibited proliferation, migration, and invasion of CAOV-3 cells, but had no effects on HOC1A cells. Therefore, IGHG1 similarly to CA166-9, could play an important role in ovarian cancer development and may serve as a potential prognostic marker and a therapeutical target for ovarian cancer.

语种: 英语
所属项目编号: 2007-2052 ; 30872750
项目资助者: Capital Medical Developing Foundation ; National Natural Science Foundation of China
WOS记录号: WOS:000362058300024
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67105
Appears in Collections:北京大学第二临床医学院_妇科肿瘤中心_期刊论文

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作者单位: 1.Peking Univ, Canc Hosp & Inst, Dept Biochem & Mol Biol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
2.Peking Univ, Peoples Hosp, Gynecol Oncol Ctr, Beijing 100044, Peoples R China

Recommended Citation:
Ji, Fangxing,Chang, Xiaohong,Liu, Caiyun,et al. Prognostic value and characterization of the ovarian cancer-specific antigen CA166-9[J]. INTERNATIONAL JOURNAL OF ONCOLOGY,2015,47(4):1405-1415.
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