学科主题临床医学
Prognostic value and characterization of the ovarian cancer-specific antigen CA166-9
Ji, Fangxing1; Chang, Xiaohong2; Liu, Caiyun2; Meng, Lin1; Qu, Like1; Wu, Jian1; Liu, Chanzhen2; Cui, Heng2; Shou, Chengchao1
关键词ovarian cancer CA166-9 antigen prognosis antigen cloning IGHG1
刊名INTERNATIONAL JOURNAL OF ONCOLOGY
2015-10-01
DOI10.3892/ijo.2015.3115
47期:4页:1405-1415
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]ANTITUMOR IMMUNE-RESPONSES ; IMMUNOGLOBULIN-G ; CELL-LINES ; MONOCLONAL-ANTIBODIES ; GENE-EXPRESSION ; CARCINOMA-CELLS ; FUSION PROTEIN ; PROLIFERATION ; INHIBITION ; DIAGNOSIS
英文摘要

COC166-9 is an ovarian cancer-specific monoclonal antibody, and C0C166-9-based immunotherapy has been shown to possess killing effects against ovarian cancer cells in vitro and in vivo. However the antigen recognized by COC166-9 (COC166-9-Ag, CA166-9) has not been identified and the clinical significance of CA166-9 expression remains unknown. We found that CA166-9 was positive in 53.1% of ovarian cancer tissues. Expression of CA166-9 was strongly correlated with the cancer recurrence (P<0.001). Patients with positive CA166-9 had substantially shorter overall survival (P=0.026) and disease-free survival (P=0.002). CA166-9 was also shown to be an independent predictive factor for overall survival (HR=2.454, P=0.016) and disease-free survival (HR=2.331, P=0.021). We identified CA166-9 as human immunoglobulin gamma-1 heavy chain constant region (IGHG1). Purified IGHG1 promoted proliferation, migration, and invasion of CA166-9-negative ovarian cancer HOC1A cells, whereas it had minimal effects on the phenotypes of CA166-9-positive ovarian cancer CAOV-3 cells. In addition, overexpression of IGHG1 enhanced migration of ovarian cancer cells. On the contrary, COC166-9 inhibited proliferation, migration, and invasion of CAOV-3 cells, but had no effects on HOC1A cells. Therefore, IGHG1 similarly to CA166-9, could play an important role in ovarian cancer development and may serve as a potential prognostic marker and a therapeutical target for ovarian cancer.

语种英语
WOS记录号WOS:000362058300024
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67105
专题北京大学临床肿瘤学院_生化与分子生物学研究室
北京大学第二临床医学院_妇科肿瘤中心
北京大学第三临床医学院_检验科
作者单位1.Peking Univ, Canc Hosp & Inst, Dept Biochem & Mol Biol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
2.Peking Univ, Peoples Hosp, Gynecol Oncol Ctr, Beijing 100044, Peoples R China
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GB/T 7714
Ji, Fangxing,Chang, Xiaohong,Liu, Caiyun,et al. Prognostic value and characterization of the ovarian cancer-specific antigen CA166-9[J]. INTERNATIONAL JOURNAL OF ONCOLOGY,2015,47(4):1405-1415.
APA Ji, Fangxing.,Chang, Xiaohong.,Liu, Caiyun.,Meng, Lin.,Qu, Like.,...&Shou, Chengchao.(2015).Prognostic value and characterization of the ovarian cancer-specific antigen CA166-9.INTERNATIONAL JOURNAL OF ONCOLOGY,47(4),1405-1415.
MLA Ji, Fangxing,et al."Prognostic value and characterization of the ovarian cancer-specific antigen CA166-9".INTERNATIONAL JOURNAL OF ONCOLOGY 47.4(2015):1405-1415.
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