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Identification and susceptibility of Rhizomucor spp. isolated from patients with cutaneous zygomycosis in China
Wang, Si-Bu; Li, Ruo-Yu; Yu, Jin
关键词morphology molecular identification antifungal susceptibility testing zygomycetous fungi
刊名MEDICAL MYCOLOGY
2011-11-01
DOI10.3109/13693786.2011.571292
49期:8页:799-805
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Mycology ; Veterinary Sciences
研究领域[WOS]Mycology ; Veterinary Sciences
关键词[WOS]IN-VITRO SUSCEPTIBILITIES ; AMPHOTERICIN-B ; ANTIFUNGAL AGENTS ; ITRACONAZOLE ; POSACONAZOLE ; VORICONAZOLE ; M38-A
英文摘要

Zygomycosis is a relatively uncommon mycosis with a morbidity that is increasing worldwide. Cutaneous zygomycosis, one of the clinical manifestations of the disease, has also emerged in recent decades. The major reported etiologic agents in China include Rhizomucor spp., Rhizopus spp., Mucor spp., and Lichtheimia spp. (formerly Absidia spp.). This study examined 11 clinical isolates of Rhizomucor that belong to three species (R. variabilis, R. regularior, and R. chlamydosporus). They were identified by both morphological and molecular methods and were found to have a high degree of correlation. In vitro susceptibility of the Rhizomucor isolates to seven antifungal drugs (amphotericin B, itraconazole, terbinafine, voriconazole, fluconazole, flucytosine, and micafungin) were tested, which resulted in amphotericin B being found to be the most active agent against all species evaluated in this study. The investigation also reviewed case reports of cutaneous zygomycosis in China.

语种英语
WOS记录号WOS:000295893300002
项目编号200802026 ; 2008ZX10004-002
资助机构Ministry of Health public service sector ; Ministry of Science &amp ; Technology of China
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67109
专题北京大学第一临床医学院
作者单位1.Peking Univ, Res Ctr Med Mycol, Beijing 100871, Peoples R China
2.Peking Univ, Dept Dermatol & Venereol, Hosp 1, Beijing 100871, Peoples R China
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Wang, Si-Bu,Li, Ruo-Yu,Yu, Jin. Identification and susceptibility of Rhizomucor spp. isolated from patients with cutaneous zygomycosis in China[J]. MEDICAL MYCOLOGY,2011,49(8):799-805.
APA Wang, Si-Bu,Li, Ruo-Yu,&Yu, Jin.(2011).Identification and susceptibility of Rhizomucor spp. isolated from patients with cutaneous zygomycosis in China.MEDICAL MYCOLOGY,49(8),799-805.
MLA Wang, Si-Bu,et al."Identification and susceptibility of Rhizomucor spp. isolated from patients with cutaneous zygomycosis in China".MEDICAL MYCOLOGY 49.8(2011):799-805.
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