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学科主题: 临床医学
题名:
Identification and susceptibility of Rhizomucor spp. isolated from patients with cutaneous zygomycosis in China
作者: Wang, Si-Bu; Li, Ruo-Yu; Yu, Jin
关键词: morphology ; molecular identification ; antifungal susceptibility testing ; zygomycetous fungi
刊名: MEDICAL MYCOLOGY
发表日期: 2011-11-01
DOI: 10.3109/13693786.2011.571292
卷: 49, 期:8, 页:799-805
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Mycology ; Veterinary Sciences
研究领域[WOS]: Mycology ; Veterinary Sciences
关键词[WOS]: IN-VITRO SUSCEPTIBILITIES ; AMPHOTERICIN-B ; ANTIFUNGAL AGENTS ; ITRACONAZOLE ; POSACONAZOLE ; VORICONAZOLE ; M38-A
英文摘要:

Zygomycosis is a relatively uncommon mycosis with a morbidity that is increasing worldwide. Cutaneous zygomycosis, one of the clinical manifestations of the disease, has also emerged in recent decades. The major reported etiologic agents in China include Rhizomucor spp., Rhizopus spp., Mucor spp., and Lichtheimia spp. (formerly Absidia spp.). This study examined 11 clinical isolates of Rhizomucor that belong to three species (R. variabilis, R. regularior, and R. chlamydosporus). They were identified by both morphological and molecular methods and were found to have a high degree of correlation. In vitro susceptibility of the Rhizomucor isolates to seven antifungal drugs (amphotericin B, itraconazole, terbinafine, voriconazole, fluconazole, flucytosine, and micafungin) were tested, which resulted in amphotericin B being found to be the most active agent against all species evaluated in this study. The investigation also reviewed case reports of cutaneous zygomycosis in China.

语种: 英语
所属项目编号: 200802026 ; 2008ZX10004-002
项目资助者: Ministry of Health public service sector ; Ministry of Science &amp ; Technology of China
WOS记录号: WOS:000295893300002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67109
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Peking Univ, Res Ctr Med Mycol, Beijing 100871, Peoples R China
2.Peking Univ, Dept Dermatol & Venereol, Hosp 1, Beijing 100871, Peoples R China

Recommended Citation:
Wang, Si-Bu,Li, Ruo-Yu,Yu, Jin. Identification and susceptibility of Rhizomucor spp. isolated from patients with cutaneous zygomycosis in China[J]. MEDICAL MYCOLOGY,2011,49(8):799-805.
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