北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学公共卫生学院  > 期刊论文
学科主题: 公共卫生
题名:
Folic Acid Supplementation During Early Pregnancy and the Risk of Gestational Hypertension and Preeclampsia
作者: Li, Zhiwen1,2; Ye, Rongwei1,2; Zhang, Le1; Li, Hongtian1; Liu, Jianmeng1; Ren, Aiguo1
关键词: folic acid supplementation ; gestational hypertension ; preeclampsia
刊名: HYPERTENSION
发表日期: 2013-04-01
DOI: 10.1161/HYPERTENSIONAHA.111.00230
卷: 61, 期:4, 页:873-879
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Peripheral Vascular Disease
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: NEURAL-TUBE DEFECTS ; PLASMA HOMOCYSTEINE ; CARDIOVASCULAR-DISEASE ; WOMEN ; FORTIFICATION ; PREVALENCE ; DISORDERS ; FOLATE ; HYPERHOMOCYSTEINEMIA ; CHINA
英文摘要:

Emerging evidence has suggested that folic acid-containing multivitamins may markedly reduce the risk of gestational hypertension or preeclampsia. We examined whether maternal supplementation with folic acid alone during early pregnancy can prevent the occurrence of gestational hypertension and preeclampsia. The data are from a large population-based cohort study established to evaluate the effectiveness of the campaign to prevent neural tube defects with folic acid supplementation in China. We selected participants who were registered in 2 southern provinces, had exact information on folic acid use, and were not affected by chronic hypertension or diabetes mellitus before 20 weeks gestation. A logistic regression model was used to adjust for the effects of the main potential confounders, including age, body mass index, education, occupation, parity, and multiple births. The study size had 99.9% power (alpha=0.05) to detect a decrease of 10% over the unexposed rate of 9.4% for gestational hypertension. Among the 193 554 women (47.9% took folic acid, 52.1% did not), the overall incidence of gestational hypertension and preeclampsia was 9.5% and 2.5%, respectively. The incidence of gestational hypertension and preeclampsia was 9.7% and 2.5% for women who took folic acid, and 9.4% and 2.4% for women who did not use it. The adjusted risk ratio associated with folic acid use was 1.08 (95% confidence interval, 1.04-1.11) for gestational hypertension and 1.11 (95% confidence interval, 1.04-1.18) for preeclampsia. Our findings suggest that daily consumption of 400 mu g folic acid alone during early pregnancy cannot prevent the occurrence of gestational hypertension and preeclampsia. (Hypertension. 2013;61:873-879.)

语种: 英语
所属项目编号: U01 DD000293
项目资助者: US Centers for Disease Control and Prevention ; Peking University Health Science Center
WOS记录号: WOS:000316112800032
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67110
Appears in Collections:北京大学公共卫生学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth,Inst Reprod & Child Hlth, Minist Hlth,Key Lab Reprod Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China

Recommended Citation:
Li, Zhiwen,Ye, Rongwei,Zhang, Le,et al. Folic Acid Supplementation During Early Pregnancy and the Risk of Gestational Hypertension and Preeclampsia[J]. HYPERTENSION,2013,61(4):873-879.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Li, Zhiwen]'s Articles
[Ye, Rongwei]'s Articles
[Zhang, Le]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Li, Zhiwen]‘s Articles
[Ye, Rongwei]‘s Articles
[Zhang, Le]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace