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Folic Acid Supplementation During Early Pregnancy and the Risk of Gestational Hypertension and Preeclampsia
Li, Zhiwen1,2; Ye, Rongwei1,2; Zhang, Le1; Li, Hongtian1; Liu, Jianmeng1; Ren, Aiguo1
关键词folic acid supplementation gestational hypertension preeclampsia
刊名HYPERTENSION
2013-04-01
DOI10.1161/HYPERTENSIONAHA.111.00230
61期:4页:873-879
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Peripheral Vascular Disease
资助者US Centers for Disease Control and Prevention ; Peking University Health Science Center ; US Centers for Disease Control and Prevention ; Peking University Health Science Center
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]NEURAL-TUBE DEFECTS ; PLASMA HOMOCYSTEINE ; CARDIOVASCULAR-DISEASE ; WOMEN ; FORTIFICATION ; PREVALENCE ; DISORDERS ; FOLATE ; HYPERHOMOCYSTEINEMIA ; CHINA
英文摘要

Emerging evidence has suggested that folic acid-containing multivitamins may markedly reduce the risk of gestational hypertension or preeclampsia. We examined whether maternal supplementation with folic acid alone during early pregnancy can prevent the occurrence of gestational hypertension and preeclampsia. The data are from a large population-based cohort study established to evaluate the effectiveness of the campaign to prevent neural tube defects with folic acid supplementation in China. We selected participants who were registered in 2 southern provinces, had exact information on folic acid use, and were not affected by chronic hypertension or diabetes mellitus before 20 weeks gestation. A logistic regression model was used to adjust for the effects of the main potential confounders, including age, body mass index, education, occupation, parity, and multiple births. The study size had 99.9% power (alpha=0.05) to detect a decrease of 10% over the unexposed rate of 9.4% for gestational hypertension. Among the 193 554 women (47.9% took folic acid, 52.1% did not), the overall incidence of gestational hypertension and preeclampsia was 9.5% and 2.5%, respectively. The incidence of gestational hypertension and preeclampsia was 9.7% and 2.5% for women who took folic acid, and 9.4% and 2.4% for women who did not use it. The adjusted risk ratio associated with folic acid use was 1.08 (95% confidence interval, 1.04-1.11) for gestational hypertension and 1.11 (95% confidence interval, 1.04-1.18) for preeclampsia. Our findings suggest that daily consumption of 400 mu g folic acid alone during early pregnancy cannot prevent the occurrence of gestational hypertension and preeclampsia. (Hypertension. 2013;61:873-879.)

语种英语
所属项目编号U01 DD000293
资助者US Centers for Disease Control and Prevention ; Peking University Health Science Center ; US Centers for Disease Control and Prevention ; Peking University Health Science Center
WOS记录号WOS:000316112800032
Citation statistics
Cited Times:31[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67110
Collection北京大学公共卫生学院
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth,Inst Reprod & Child Hlth, Minist Hlth,Key Lab Reprod Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Li, Zhiwen,Ye, Rongwei,Zhang, Le,et al. Folic Acid Supplementation During Early Pregnancy and the Risk of Gestational Hypertension and Preeclampsia[J]. HYPERTENSION,2013,61(4):873-879.
APA Li, Zhiwen,Ye, Rongwei,Zhang, Le,Li, Hongtian,Liu, Jianmeng,&Ren, Aiguo.(2013).Folic Acid Supplementation During Early Pregnancy and the Risk of Gestational Hypertension and Preeclampsia.HYPERTENSION,61(4),873-879.
MLA Li, Zhiwen,et al."Folic Acid Supplementation During Early Pregnancy and the Risk of Gestational Hypertension and Preeclampsia".HYPERTENSION 61.4(2013):873-879.
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