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Fructus ligustri lucidi Ethanol Extract Improves Bone Mineral Density and Properties Through Modulating Calcium Absorption-Related Gene Expression in Kidney and Duodenum of Growing Rats
Feng, Xin1; Lyu, Ying1; Wu, Zhenghao1; Fang, Yuehui1; Xu, Hao1; Zhao, Pengling2; Xu, Yajun1,3; Feng, Haotian2
关键词1 alpha-Hydroxylase CaBP-9k Calcium absorption Fructus ligustri lucidi TRPV6 VDR
刊名CALCIFIED TISSUE INTERNATIONAL
2014-04-01
DOI10.1007/s00223-013-9825-4
94期:4页:433-441
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism
研究领域[WOS]Endocrinology & Metabolism
关键词[WOS]VITAMIN-D METABOLISM ; OLEANOLIC ACID ; URSOLIC ACID ; 1,25-DIHYDROXYVITAMIN D-3 ; OSTEOCLAST FORMATION ; OVARIECTOMIZED RATS ; HIP FRACTURE ; SERUM CTX ; IN-VITRO ; WOMEN
英文摘要

Optimizing peak bone mass in early life is one of key preventive strategies against osteoporosis. Fructus ligustri lucidi (FLL), the fruit of Ligustrum lucidum Ait., is a commonly prescribed herb in many kidney-tonifying traditional Chinese medicinal formulas to alleviate osteoporosis. Previously, FLL extracts have been shown to have osteoprotective effect in aged or ovariectomized rats. In the present study, we investigated the effects of FLL ethanol extract on bone mineral density (BMD) and mechanical properties in growing male rats and explored the underlying mechanisms. Male weaning Sprague-Dawley rats were randomized into four groups and orally administrated for 4 months an AIN-93G formula-based diet supplementing with different doses of FLL ethanol extract (0.40, 0.65, and 0.90 %) or vehicle control, respectively. Then calcium balance, serum level of Ca, P, 25(OH)(2)D-3, 1,25(OH)(2)D-3, osteocalcin (OCN), C-terminal telopeptide of type I collagen (CTX-I), and parathyroid hormone, bone microarchitecture, and calcium absorption-related genes expression in duodenum and kidney were analyzed. The results demonstrated that FLL ethanol extract increased BMD of growing rats and improved their bone microarchitecture and mechanical properties. FLL ethanol extract altered bone turnover, as evidenced by increasing a bone formation maker, OCN, and decreasing a bone resorption maker, CTX-I. Intriguingly, both Ca absorption and Ca retention rate were elevated by FLL ethanol extract treatment, possibly through the mechanisms of up-regulating the transcriptions of calcitropic genes in kidney (1 alpha-hydroxylase) and duodenum (vitamin D receptor, calcium transporter calbindin-D9k, and transient receptor potential vanilloid 6). In conclusion, FLL ethanol extract increased bone mass gain and improved bone properties via modulating bone turnover and up-regulating calcium absorption-related gene expression in kidney and duodenum, which could then activate 1,25(OH)(2)D-3-dependent calcium transport in male growing rats.

语种英语
WOS记录号WOS:000332948100009
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67114
专题北京大学公共卫生学院
作者单位1.Nestle Res Ctr, Beijing 100095, Peoples R China
2.Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100191, Peoples R China
3.Beijing Key Lab Toxicol Res & Risk Assessment Foo, Beijing 100191, Peoples R China
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GB/T 7714
Feng, Xin,Lyu, Ying,Wu, Zhenghao,et al. Fructus ligustri lucidi Ethanol Extract Improves Bone Mineral Density and Properties Through Modulating Calcium Absorption-Related Gene Expression in Kidney and Duodenum of Growing Rats[J]. CALCIFIED TISSUE INTERNATIONAL,2014,94(4):433-441.
APA Feng, Xin.,Lyu, Ying.,Wu, Zhenghao.,Fang, Yuehui.,Xu, Hao.,...&Feng, Haotian.(2014).Fructus ligustri lucidi Ethanol Extract Improves Bone Mineral Density and Properties Through Modulating Calcium Absorption-Related Gene Expression in Kidney and Duodenum of Growing Rats.CALCIFIED TISSUE INTERNATIONAL,94(4),433-441.
MLA Feng, Xin,et al."Fructus ligustri lucidi Ethanol Extract Improves Bone Mineral Density and Properties Through Modulating Calcium Absorption-Related Gene Expression in Kidney and Duodenum of Growing Rats".CALCIFIED TISSUE INTERNATIONAL 94.4(2014):433-441.
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